Body Composition and Water Compartment Measurements in Boys with Duchenne Muscular Dystrophy

Abstract

DMD patients have elevated ECW/ICW ratios compared with obese subjects and nonobese controls. However, obese subjects and nonobese controls had similar ECW/ICW ratios, despite the increased fat tissue mass in obese subjects. This suggests that the elevated ECW/ICW ratios in DMD subjects are not due to increased fat mass but rather some other mechanism, likely impaired cellular homeostasis due to muscle membrane instability. Although MFBIA slightly underestimates lean tissue mass in boys with DMD, it has a potential role as an inexpensive and easy to use measurement tool to measure changes in muscle mass in the clinical setting.

Correlação da massa e porcentagem de gordura com a idade na distrofia muscular de Duchenne

“…A porcentagem de gordura desse grupo foi de 41,1 ± 20,5% encontrando-se elevada quando comparada com os valores descritos por Deurenberg (28). A massa de gordura foi de 8,46 ± 6,21 kg, compatível com o encontrado no estudo de McDonald (22), cujos valores apresentados foram de 10,5 ± 2,1 kg.…”

Assessment of regional body composition with dual‐energy X‐ray absorptiometry in Duchenne muscular dystrophy: Correlation of regional lean mass and quantitative strength

“…A DEXA total-body scanner (QDR-4500A; Hologic, Inc., Bedford, Massachusetts) was used to obtain regional and wholebody composition measurements using a three-compartment model of body composition: LTM, FTM, and BMC. We utilized the same protocol previously described by McDonald et al 6 For regional body composition measures, Hologic post-processing soft-ware (Whole Body, version 8.26a:3a) was used to define body segments (trunk, entire arm, upper arm, entire leg, thigh, and lower leg). The forearm region was estimated by subtracting the upper arm value from the entire arm value.…”

The cooperative international neuromuscular research group duchenne natural history study—a longitudinal investigation in the era of glucocorticoid therapy: Design of protocol and the methods used

“…Non-ambulatoryparticipants are weighed in theirwheelchairs. Wheelchairs are weighedseparately and subtracted from the totalweight of wheelchair plus participant toarrive at the participant weight. + All 5 min 2006–present Vital signs Heart rate, respiratory rate, and bloodpressure. + All 2 min 2006–present Body composition(DEXA) As described in Skalsky et al 23 + All Chart review 2006–present Body composition(bioelectricalimpedance) As described in McDonald et al 24 + All Chart review 2006–present Bone health (DEXA) As described by Escolar et al 25 + All Chart review 2006–present Passive range ofmotion(goniometry) 11,26 Knee and elbow extension ranges are from20 to 2150 degrees. Ankle dorsiflexionrange is from 20 to −80 degrees, with 0degree considered full passive range ofmotion.…”