Assessment of regional body composition with dual‐energy X‐ray absorptiometry in Duchenne muscular dystrophy: Correlation of regional lean mass and quantitative strength

Abstract

The purpose of this study was to assess regional body composition and its correlation with regional strength in Duchenne muscular dystrophy (DMD) subjects and able-bodied controls. Regional dual-energy X-ray absorptiometry (DEXA) measurements and isometric strength were obtained for 23 DMD subjects and 23 control subjects. DMD subjects showed a decreased regional lean mass (P < 0.001). The correlation between regional strength and regional lean mass was stronger for controls than for DMD subjects. DMD subjects had decreased regional lean mass, increased regional fat mass, and decreased strength. Muscle Nerve 39: 647-651, 2009.

Regional body composition and functional impairment in patients with myotonic dystrophy

“…Moreover, DM1 patients carry the additional risk of insulin resistance and subsequent metabolic risk factors, such as obesity due to sedentary lifestyle, reduced mobility, and resting energy expenditure, as shown in patients with other NMDs. 3,16,17 Although our study was not designed to determine the prevalence of obesity in the DM1 population, it is worth noting that overweight was found in about 50% of the DM1 patients in this study, whereas 25% could be considered obese according to the World Health Organization definition (BMI >30 kg/m 2 ). Obesity aggravates handicap, and increased fat mass is an additional burden on already severely weakened muscles.…”

Correlação da massa e porcentagem de gordura com a idade na distrofia muscular de Duchenne

“…A obesidade é comum na DMD (12)(13)(14)(15)(16). Um estudo com nove crianças portadoras de DMD com idade de 6 a 12 anos mostrou que cerca da metade desenvolveu obesidade, o que constitui sobrecarga ao trabalho desenvolvido pela musculatura esquelética (17).…”

Scientific Posters

“…Dietary intake and undernutrition in preschool children with cerebral palsy: comparison between high-and low-resource countries K BENFER 1,2 Participants and Setting: Hundred and eighty children with CP aged 18 to 36 months, 81 children born in Bangladesh (mean age=27.6mo, 50 males, GMFCS I-II=23.5%, III=30.9%, IV-V=45.7%) and 99 children born in Queensland, Australia (mean age=27.1mo, 65 males, GMFCS I-II=56.2%, III=17.7%, IV-V=26.2%). Methods: Parents reported on their child's dietary intake using a 1 day (Bangladesh, BD) and 3 day (Australia, AU) weighed record.…”

“…Measuring physical function in children with cerebral palsy using the PEDI-CAT: a validation analysis BJ SHORE 1,2 Background/Objectives: Individuals with physical disabilities such as cerebral palsy (CP) have been shown to have decreased bone mass and an increased risk for fracture in the lower extremities. A floor based, high-frequency, low-magnitude vibration (HLV) stimulus has been shown to have anabolic properties on bone.…”

“…Previous studies have examined this relationship using regional LBM. 1 Longitudinal analyses have not been performed. The purpose of this study was to examine the validity of LBM as a proxy for muscle strength.…”