Body Composition And Serum Leptin And Adiponectin In COPD Patients In Relation To The GOLD Stage

Abstract

Rationale: Weight loss and cachexia are relevant systemic manifestations of chronic obstructive pulmonary disease (COPD) and belong to the negative prognostic factors in this disease. The aim of our study was to analyze body composition and serum leptin and adiponectin in COPD patients categorized according to the GOLD stage (II-IV) . Material :The study group consisted of 67 COPD patients (43 M, and 24 F, at mean age 68.2±8 yrs, and FEV of 51.6±14.2% pred.). There 1 were 33 patients in GOLD II, 23 patients in GOLD III and 11 patients in GOLD IV stage, respectively. 12 patients were current smokers and the cumulative tobacco exposure for the whole group was 40.2± 18.7 pack-years. Methods: Body composition was analyzed by bioelectric impendence with Tanita T5896 balance. All patients had also undergone spirometry and body plethysmography (Vmax V6200 Autobox) and 6-minute walk test (6MWT), leptin and adiponectin was measured using the ELISE test (R&D Systems). Results:3. Basal metabolic rate (BMR) decreases with COPD severity and correlates with lung hyperinflation This abstract is funded by: National Center for Science and Progress ( NCBiR) Poland Am J Respir Crit Care Med 185;2012:A4515 Internet address: www.atsjournals.org Online Abstracts Issue