Body cavities as bioreactors to grow arteries

Campbell, Julie H.; Walker, Philip J.; Chue, Wai-Leng; Daly, Christopher; Cong, H.; Xiang, Lina; Campbell, Gordon

doi:10.1016/j.ics.2003.11.022

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The methods for graft fabrication, that is, polycaprolactone (PCL)/ chitosan (Fukunishi et al, 2016) Not reported for rat or rabbit models, but for canine model took 2-3 months for complete scaffold degradation These studies looked at vascular grafts in large and small animal models not through the use of printed scaffolds and endogenous neotissue formation at the site of vascular repair, but through incubation of biodegradable scaffolds in the peritoneal cavity of the animals, and then using the ectopic neoformed vessels for autologous grafting within the same animal itself. (Campbell et al, 2004, Campbell, Efendy, & Campbell, 1999, Campbell, Efendy, Han, Girjes, & Campbell, 2000 PGA scaffold seeded with smooth muscle cells 1. Canine model of peripheral and coronary artery bypass 2.…”

Section: Graft Fabricationmentioning

confidence: 99%

Different degradation rates of nanofiber vascular grafts in small and large animal models

Fukunishi

Ong

Yesantharao

et al. 2020

J Tissue Eng Regen Med

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Nanofiber vascular grafts have been shown to create neovessels made of autologous tissue, by in vivo scaffold biodegradation over time. However, many studies on graft materials and biodegradation have been conducted in vitro or in small animal models, instead of large animal models, which demonstrate different degradation profiles. In this study, we compared the degradation profiles of nanofiber vascular grafts in a rat model and a sheep model, while controlling for the type of graft material, the duration of implantation, fabrication method, type of circulation (arterial/venous), and type of surgery (interposition graft). We found that there was significantly less remaining scaffold (i.e., faster degradation) in nanofiber vascular grafts implanted in the sheep model compared with the rat model, in both the arterial and the venous circulations, at 6 months postimplantation. In addition, there was more extracellular matrix deposition, more elastin formation, more mature collagen, and no calcification in the sheep model compared with the rat model. In conclusion, studies comparing degradation of vascular grafts in large and small animal models remain limited. For clinical translation of nanofiber vascular grafts, it is important to understand these differences.

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Section: Graft Fabricationmentioning

confidence: 99%

Different degradation rates of nanofiber vascular grafts in small and large animal models

Fukunishi

Ong

Yesantharao

et al. 2020

J Tissue Eng Regen Med

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“…Given the short-term outcomes of maintaining patency following implantation of these devices, the use of larger animal model body cavities as bioreactors was employed by this same group [36,37]. In this series of experiments, bare or PGA-coated tubing was implanted into the peritoneal or pleural cavities of dogs and harvested after 3 weeks.…”

Section: Tevg Methodsmentioning

confidence: 99%

Tissue engineered vascular grafts: Origins, development, and current strategies for clinical application

Benrashid

McCoy

Youngwirth

et al. 2016

Methods

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“…The aim of small diameter blood vessel TE is to create autologous replacement vessels for use in vascular replacement surgery, amongst others [36]. These conduits need to closely resemble the native vessel, not only in dimension but also in physiological responsiveness, cellular constituents, and mechanical properties as well as in its relaxing and antithrombotic factors released at the cellular level [37]. Liu et al (2007) [34] developed a novel method for isolating SMCs from ovine bone marrow using a tissuespecific promoter and fluorescence-activated cell sorting, for potential use in cardiovascular tissue regeneration applications.…”

Section: Cardiovascular Applications Of Smcsmentioning

confidence: 99%

Adipose Derived Stem Cells and Smooth Muscle Cells: Implications for Regenerative Medicine

Villiers

Houreld

Abrahamse

2009

Stem Cell Rev and Rep

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The treatment of chronic wounds and other damaged tissues and organs remains a difficult task, in spite of greater adherence to recognised standards of care and a better understanding of pathophysiologic principles. Adipose derived stem cells (ADSCs), with their proliferative and impressive differentiation potential, may be used in the future in autologous cell therapy or grafting to replace damaged tissues. At this point in time, transplanted tissues are often rejected by the body. Autologous grafting would eliminate this problem. ADSCs are able to differentiate into a number of cells in vitro, for example smooth muscle cells (SMCs), when treated with lineage specific factors. SMCs play a key role in physiology and pathology as they form the principle layer of all SMC tissues. Smooth muscle biopsies are often impractical and morbid, and often lead to a low cell harvest. It has also been shown that SMCs derived from a diseased organ can lead to abnormal cells. Therefore, there is a great need for alternative sources of healthy SMCs. The use of ADSCs for cell-based tissue engineering (TE) represents a promising alternative for smooth muscle repair. This review discusses the potential uses of ADSCs and SMCs in regenerative medicine, and the potential of ADSCs to be differentiated into functional SMCs for TE and regenerative cellular therapies to repair diseased organs.

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Body cavities as bioreactors to grow arteries

Cited by 5 publications

References 9 publications

Different degradation rates of nanofiber vascular grafts in small and large animal models

Different degradation rates of nanofiber vascular grafts in small and large animal models

Tissue engineered vascular grafts: Origins, development, and current strategies for clinical application

Adipose Derived Stem Cells and Smooth Muscle Cells: Implications for Regenerative Medicine

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