Body and organ growth of the developing Hormel-Hanford strain of male miniature swine

Friedman, Leonard; Gaines, Dennis; Newell, Richard; Sager, Arlen O.; Matthews, Roger N.; Braunberg, Robert C.

doi:10.1258/002367794780745083

Cited by 13 publications

(7 citation statements)

References 12 publications

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“…The Hanford minipigs maintain a low but constant growth rate in brain weight from 30 to 176 days after birth ( Fig. 1 in Friedman et al, 1994). The continued but decreased rate of sutural mineralization in the period of 3-7 months, therefore, consistent with the notion that sutural growth follows brain growth.…”

Section: Sutural Growthsupporting

confidence: 68%

Cranial sutures and bones: Growth and fusion in relation to masticatory strain

2004

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Cranial bones and sutures are mechanically loaded during mastication. Their response to masticatory strain, however, is largely unknown, especially in the context of age change. Using strain gages, this study investigated masticatory strain in the posterior interfrontal and the anterior interparietal sutures and their adjacent bones in 3-and 7-month-old miniature swine (Sus scrofa). Double-fluorochrome labeling of these animals and an additional 5-month group was used to reveal suture and bone growth as well as features of suture morphology and fusion. With increasing age, the posterior interfrontal suture strain decreased in magnitude and changed in pattern from pure compression to both compression and tension, whereas the interparietal suture remained in tension and the magnitude increased unless the suture was fused. Morphologically, the posterior interfrontal suture was highly interdigitated at 3 months and then lost interdigitation ectocranially in older pigs, whereas the anterior interparietal suture remained butt-ended. Mineralization apposition rate (MAR) decreased with age in both sutures and was unrelated to strain. Bone mineralization was most vigorous on the ectocranial surface of the frontal and the parietal bones. Unlike the sutures, with age bone strain remained constant while bone MARs significantly increased and were correlated with bone thickness. Fusion had occurred in the interparietal suture of some pigs. In all cases fusion was ectocranial rather than endocranial. Fusion appeared to be associated with increased suture strain and enhanced bone growth on the ectocranial surface. Collectively, these results indicate that age is an important factor for strain and growth of the cranium. Anat Rec Part A 276A: 150 -161, 2004.

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Section: Sutural Growthsupporting

confidence: 68%

Cranial sutures and bones: Growth and fusion in relation to masticatory strain

2004

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“…The Hanford minipigs maintain a low but constant growth rate in brain weight from 30 to 176 days after birth (Fig. 1 in Friedman et al,1994). The continued but decreased rate of sutural mineralization in the period of 3‐7 months, therefore, consistent with the notion that sutural growth follows brain growth.…”

Section: Discussionmentioning

confidence: 99%

pH Transitions in Ion‐Exchange Systems: Role in the Development of a Cation‐Exchange Process for a Recombinant Protein

Ghose

McNerney

Hubbard

2002

Biotechnology Progress

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Unexpected transient changes in effluent pH can occur during ion-exchange chromatography. Such changes can occur even if a column that is equilibrated with a buffer receives another solution in the same buffer and of the same pH but of a different salt concentration. An attempt is made to understand the basis for this phenomenon and apply it to the process purification of a recombinant protein on a strong cation-exchange resin. Incomplete column equilibration was eliminated as a possible cause of these effects. Various buffering species and various salt ions were studied at different solution concentrations to investigate pH transitions on strong cation-exchange resins. A further comparison was made between cation-exchange resins with different backbone chemistries. On the basis of these studies, a mechanism is proposed for these phenomena based on competitive equilibria between ions from the buffer salts and H(+)/OH(-) ions. In addition to the equilibria between these ions and the functional groups on the resins, charged groups on the resin backbone were also found to contribute to transient pH changes. The results from this study were applied to the cation-exchange step for a recombinant protein that was sensitive to pH excursions to help maintain activity of the protein during the purification process.

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“…During this time, the animals can increase their body weight ~82 times, whereas the increase of weight of the liver and spleen is reported to be 50 and 117 times, respectively. 7 Such asynchronous development may result in disturbances in some physiologic functions, including mechanisms of hemostasis. Hemostatic processes—a very complex system of blood clotting and fibrinolysis—play an important role in many physiologic and pathologic phenomena, including healing of damaged tissues, inflammatory reactions, and antimicrobial response.…”

mentioning

confidence: 99%

“…5,8,20,25 Swine have several advantages that make them promising subjects for biomedical research, including intensive growth and maturation, short gestation time, prolificacy, low rearing costs, and a relatively low risk of transmission of infectious diseases to humans. 7–9,20 The swine model has been used in research into pathogenesis of human cardiovascular diseases, disseminated intravascular coagulation, shock, atherosclerosis, diabetes, metabolic disturbances, as well as hereditary disorders. 5,8,14,20–22 Because the pig resembles the human in physiology and organ development, intensive studies on the possibility of using porcine organs for xenotransplantation to humans have also been performed.…”

mentioning

confidence: 99%

Age-related changes of platelet and plasma coagulation parameters in young pigs

et al. 2016

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Abstract. The literature on hemostatic processes in swine is sparse and often fragmentary; hence, we conducted our study to characterize age-related changes in selected parameters of primary and secondary hemostasis in 50 growing pigs between day 2 and week 24 of age. We measured platelet count (PLT), mean platelet volume, platelet-to-large cell ratio, prothrombin time, activated partial thromboplastin time (aPTT), thrombin time (TT), and fibrinogen concentration. Among primary hemostasis parameters, PLT underwent the largest fluctuation with the animals' age, ranging from 340 to 730 × 10 9 /L. However, statistical significance was only detected for 4-week-old piglets compared to 18-week-old animals. Of the secondary hemostasis parameters measured, TT and aPTT were the most changeable. Activated partial thromboplastin time displayed a characteristic biphasic course, being relatively short before week 5 of age (17.8-19.9 s) and then becoming much longer (28.7-52.5 s). The aPTTs measured in animals 6 weeks of age and older were statistically different (p < 0.01) from those in younger piglets. The 2 main components of hemostasis, platelet hemostasis and plasma coagulation, did not develop at the same time. It took much longer for secondary hemostasis to stabilize, whereas platelet parameters were stable early in life.

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Body and organ growth of the developing Hormel-Hanford strain of male miniature swine

Cited by 13 publications

References 12 publications

Cranial sutures and bones: Growth and fusion in relation to masticatory strain

Cranial sutures and bones: Growth and fusion in relation to masticatory strain

pH Transitions in Ion‐Exchange Systems: Role in the Development of a Cation‐Exchange Process for a Recombinant Protein

Age-related changes of platelet and plasma coagulation parameters in young pigs

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