BMP4 and Madh5 regulate the erythroid response to acute anemia

Lenox, Laurie; Perry, John M.; Paulson, Robert F.

doi:10.1182/blood-2004-02-0703

Cited by 177 publications

(299 citation statements)

References 41 publications

(35 reference statements)

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“…It is, however, interesting to note that the BMP pathway has been previously linked to stress erythropoiesis, as will be discussed below. 44,45 The mechanism by which TIF1g cooperates with Smads continues to be a controversial issue. Developmental studies from a variety of species have suggested that TIF1g, also known as Ectodermin, acts as a ubiquitin ligase for Smad4, thus functioning as a direct inhibitor of Smad4 downstream of TGF-b and BMP signaling.…”

Section: Tgf-b Signaling Diversified: a Role For Transcriptional Intementioning

confidence: 99%

The role of Smad signaling in hematopoiesis and translational hematology

2011

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Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self-renewal and differentiation, has remained elusive, partly because of the expansive plethora of factors and signaling cues that govern HSC behavior in vivo. In the BM, HSCs are housed in specialized niches that dovetail the behavior of HSCs with the need of the organism. The Smad-signaling pathway, which operates downstream of the transforming growth factor-b (TGF-b) superfamily of ligands, regulates a diverse set of biological processes, including proliferation, differentiation and apoptosis, in many different organ systems. Much of the function of Smad signaling in hematopoiesis has remained nebulous due to early embryonic lethality of most knockout mouse models. However, recently new data have been uncovered, suggesting that the Smad-signaling circuitry is intimately linked to HSC regulation. In this review, we bring the Smad-signaling pathway into focus, chronicling key concepts and recent advances with respect to TGF-b-superfamily signaling in normal and leukemic hematopoiesis.

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Section: Tgf-b Signaling Diversified: a Role For Transcriptional Intementioning

confidence: 99%

The role of Smad signaling in hematopoiesis and translational hematology

2011

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“…The absence of BMPRIA caused increased numbers of HSC-supporting osteoblastic cells lining the bone surface, which in turn led to an increase in the numbers of HSCs in these mice . A role for BMP signaling in stress erythropoiesis in the spleen has recently been described (Lenox et al, 2005) Interfering with the entire Smad pathway Since Smad7 has been shown to block all Smad signaling pathways, enforced expression of Smad7 can be used to greatly reduce or eliminate Smad signaling in HSC. Recently, overexpression of Smad7 in human CD34 þ hematopoietic cells was found to augment myeloid differentiation at the expense of lymphoid commitment (Chadwick et al, 2005).…”

Section: The Bmps In Adult Hematopoiesismentioning

confidence: 99%

The role of Smad signaling in hematopoiesis

2005

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“…However, a subsequent study demonstrated that it was the mutation of Madh5 that affected the ability of f/f mice to respond to acute anemia and the attribution of Sfxn1 mutation to the f/f phenotypes was in doubt (Lenox et al, 2005). Unlike other MCs, SFXN lacks the canonical internal tripartite structure (Azzi et al, 1993;Fleming et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Developmental expression of sideroflexin family genes in Xenopus embryos

Han

Kam

et al. 2010

Developmental Dynamics

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Emerging evidence indicates that mitochondrial carriers are not only crucial for metabolism, but also important for embryonic development. Sideroflexin is a novel family of mitochondrial tricarboxylate carrier proteins, of which the in vivo function is largely unknown. Here, we report on the expression patterns of five sideroflexin genes in Xenopus embryos. Whole-mount in situ hybridization analysis reveals that while sideroflexin2 is expressed in the pancreas, sideroflexin1 and 3 display a complex expression in the central nervous system, somites, pronephros, liver, and pancreas. In contrast, only a weak expression of sideroflexin4 and 5 was detected in embryonic brain. Taken together, the five sideroflexin genes show both overlapping and nonoverlapping expression during Xenopus embryogenesis. As the primary structures of the five sideroflexin proteins are also quite similar, their functional redundancy should be taken into consideration for gene targeting studies. Developmental Dynamics 239:2742-2747,

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BMP4 and Madh5 regulate the erythroid response to acute anemia

Cited by 177 publications

References 41 publications

The role of Smad signaling in hematopoiesis and translational hematology

The role of Smad signaling in hematopoiesis and translational hematology

The role of Smad signaling in hematopoiesis

Developmental expression of sideroflexin family genes in Xenopus embryos

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