BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice

Core‐Sheath Fibers for Regenerative Medicine

“…Recently emulsion electrospinning has emerged as another technique for prefabrication encapsulation of bioactive molecules [72][73][74][75][76][77][78][79][80]. Emulsion electrospinning involves the spinning of two immiscible solutions simultaneously.…”

Nanofibrous Structure of Chitosan for Biomedical Applications

“…In the study of skeletal muscle tissue attachment and proliferation, Cooper et al [79] Chitosan based polyblend nanofibers with synthetic biopolymer polymers such as PEO, PLGA, PLLA, PVA and Hydroxyapatite (HAP) have been used as potential biomimetic scaffolds to engineer several others tissues such as bone, cartilage, tendon, etc., [48,67,76,[80][81][82][83][84]. The ability of chitosan to support cell attachment and proliferation is attributed to its chemical properties.…”

Efficiently engineered cell sheet using a complex of polyethylenimine–alginate nanocomposites plus bone morphogenetic protein 2 gene to promote new bone formation

“…19 BMP-2 gene transfection has been investigated for bone regeneration as an alternative to BMP-2 protein therapy. 4,5,20 So far, the main approach to gene delivery in gene therapy is viral vector systems, due to their relatively high transfection efficiency. However, the use of nonviral gene vectors has emerged as a viable alternative to viral-based gene vectors, because they overcome the limitation of viral vectors, such as immune response, oncogenicity, and difficulty in large-scale production and purification.…”