BMP-2 and BMP-4, but Not BMP-6, Increase the Number of Adrenergic Cells Which Develop in Quail Trunk Neural Crest Cultures

Varley, Joel E.; Maxwell, Gerald D.

doi:10.1006/exnr.1996.0118

Cited by 120 publications

(79 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Once the NC cells reach the dorsal aorta, they receive an inductive cue, thought to be BMPs, to activate the SNS-specific differentiation program (Reissmann et al, 1996). The dorsal aorta expresses Bmp2, Bmp4 and Bmp7, and all have been shown to activate the SNS developmental program in vitro (Reissmann et al, 1996;Shah et al, 1996;Varley and Maxwell, 1996). In addition, inhibition of BMPs by implantation of noggin-soaked beads by the dorsal aorta prevents NC cells from differentiating into neurons (Schneider et al, 1999), further supporting a role for BMPs in SNS development.…”

Section: Introductionmentioning

confidence: 88%

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

et al. 2009

View full text Add to dashboard Cite

Induction of the sympathetic nervous system (SNS) from its neural crest (NC) precursors is dependent on BMP signaling from the dorsal aorta. To determine the roles of BMP signaling and the pathways involved in SNS development, we conditionally knocked out components of the BMP pathways. To determine if BMP signaling is a cell-autonomous requirement of SNS development, the Alk3 (BMP receptor IA) was deleted in the NC lineage. The loss of Alk3 does not prevent NC cell migration, but the cells die immediately after reaching the dorsal aorta. The paired homeodomain factor Phox2b, known to be essential for survival of SNS precursors, is downregulated, suggesting that Phox2b is a target of BMP signaling. To determine if Alk3 signals through the canonical BMP pathway, Smad4 was deleted in the NC lineage. Loss of Smad4 does not affect neurogenesis and ganglia formation; however, proliferation and noradrenergic differentiation are reduced. Analysis of transcription factors regulating SNS development shows that the basic helix-loop-helix factor Ascl1 is downregulated by loss of Smad4 and that Ascl1 regulates SNS proliferation but not noradrenergic differentiation. To determine if the BMP-activated Tak1 (Map3k7) pathway plays a role in SNS development, Tak1 was deleted in the NC lineage. We show that Tak1 is not involved in SNS development. Taken together, our results suggest multiple roles for BMP signaling during SNS development. The Smad4-independent pathway acts through the activation of Phox2b to regulate survival of SNS precursors, whereas the Smad4-dependent pathway controls noradrenergic differentiation and regulates proliferation by maintaining Ascl1 expression.

show abstract

Section: Introductionmentioning

confidence: 88%

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Taken together, these findings support the speculation that ART might participate in hematopoietic and/or skeletal development. This possibility is made more plausible by recent reports that other TGFβ superfamily members that regulate skeletal development (bone morphogenetic proteins [BMP]) also contribute to sympathoadrenal differentiation (Varley and Maxwell, 1996;Schneider et al, 1999;McPherson et al, 2000;Sasai, 2001), and that neurotrophic factors may exert influence on bone marrow (Labouyrie et al, 1999).…”

Section: Recombinant Art Does Not Relieve Neuropathic Painmentioning

confidence: 99%

The Candidate Neuroprotective Agent Artemin Induces Autonomic Neural Dysplasia without Preventing Peripheral Nerve Dysfunction

et al. 2004

View full text Add to dashboard Cite

Artemin (ART) signals through the GFRα-3/RET receptor complex to support sympathetic neuron development. Here we show that ART also influences autonomic elements in adrenal medulla and enteric and pelvic ganglia. Transgenic mice over-expressing Art throughout development exhibited systemic autonomic neural lesions including fusion of adrenal medullae with adjacent paraganglia, adrenal medullary dysplasia, and marked enlargement of sympathetic (superior cervical and sympathetic chain ganglia) and parasympathetic (enteric, pelvic) ganglia. Changes began by gestational day 12.5 and formed progressively larger masses during adulthood. Art supplementation in wild type adult mice by administering recombinant protein or an Art-bearing retroviral vector resulted in hyperplasia or neuronal metaplasia at the adrenal corticomedullary junction. Expression data revealed that Gfrα-3 is expressed during development in the adrenal medulla, sensory and autonomic ganglia and their projections, while Art is found in contiguous mesenchymal domains (especially skeleton) and in certain nerves. Intrathecal Art therapy did not reduce hypalgesia in rats following nerve ligation. These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy.

show abstract

“…Many of the anterior segment development genes discussed in this review can directly or indirectly affect levels of tyrosine hydroxylase. BMP4, PAX6 and LMX1B can promote tyrosine hydroxylase activity or proliferation of tyrosine hydroxylase expressing neural crest cells (Varley and Maxwell 1996, Dellovade et al, 1998, Vitalis et al, 2000. Mutations of these genes could affect the supply of L-dopa available to the developing ocular structures.…”

Section: Tyrosinase Tyrosine Hydroxylase Dopa and Asdmentioning

confidence: 99%

Anterior segment development relevant to glaucoma

Gould¹,

Smith²,

John³

2004

Int. J. Dev. Biol.

165

121

View full text Add to dashboard Cite

BMP-2 and BMP-4, but Not BMP-6, Increase the Number of Adrenergic Cells Which Develop in Quail Trunk Neural Crest Cultures

Cited by 120 publications

References 0 publications

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathways

The Candidate Neuroprotective Agent Artemin Induces Autonomic Neural Dysplasia without Preventing Peripheral Nerve Dysfunction

Anterior segment development relevant to glaucoma

Contact Info

Product

Resources

About