BMI1 in the heart: Novel functions beyond tumorigenesis

Yang, Dan; Liu, Hanqing; Zheng, Yang; Fan, Di; Tang, Qi‐Zhu

doi:10.1016/j.ebiom.2020.103193

Cited by 14 publications

(9 citation statements)

References 87 publications

(97 reference statements)

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“…Many small-molecule BMI-1 inhibitors, such as PTC-209, PTC-028, and PTC596, suppress self-renewal ability, tumor growth, and cancer invasion [ 15 ]. In addition, these inhibitors induce cell death in various cancer cells [ 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization

Woo

Seo

et al. 2021

IJMS

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BMI-1, a polycomb ring finger oncogene, is highly expressed in multiple cancer cells and is involved in cancer cell proliferation, invasion, and apoptosis. BMI-1 represents a cancer stemness marker that is associated with the regulation of stem cell self-renewal. In this study, pharmacological inhibition (PTC596) or knockdown (siRNA) of BMI-1 reduced cancer stem-like cells and enhanced cancer cell death. Mechanistically, the inhibition of BMI-1 induced the downregulation of Mcl-1 protein, but not Mcl-1 mRNA. PTC596 downregulated Mcl-1 protein expression at the post-translational level through the proteasome-ubiquitin system. PTC596 and BMI-1 siRNA induced downregulation of DUB3 deubiquitinase, which was strongly linked to Mcl-1 destabilization. Furthermore, overexpression of Mcl-1 or DUB3 inhibited apoptosis by PTC596. Taken together, our findings reveal that the inhibition of BMI-1 induces Mcl-1 destabilization through downregulation of DUB3, resulting in the induction of cancer cell death.

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Section: Introductionmentioning

confidence: 99%

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization

Woo

Seo

et al. 2021

IJMS

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“…One new coumarin (1) and 15 known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) were isolated from M. siamensis, guided by BMI1 promoter inhibitory activity. Coumarin derivatives 2 and 4-12 suppresses the BMI1 promoter and compound 5 shows strong cytotoxicity against Huh7 and HCT116 cells.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] BMI1 is an essential self-renewal regulator for multiple stem cell systems, such as hematopoietic, nerves, and breast stem cells, and BMI1 is also highly expressed in various tumor tissues. 6,7) Especially, BMI1 is known to be highly expressed in cancer stem cells (CSCs) that contribute to cancer recurrence and metastasis due to their resistance to chemotherapy and radiation therapy. [8][9][10] Therefore, compounds with BMI1 promoter inhibitory activity may lead to a decrease in cancer stem cells, providing a fundamental treatment for cancer.…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>

Fujii

Hara

Arai

et al. 2022

CHEMICAL & PHARMACEUTICAL BULLETIN

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A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibitory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC 50 value of 25.4 µM. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.

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“…The protein Bmi1, another member of the PRC1 family, is a well-recognized transcriptional suppressor and is capable of preventing premature senescence and maintaining the selfrenewal of tissue-specific stem cells (42). Brian et al found that Bmi1 is expressed by incisor epithelial stem cells and that deletion of Bmi1 results in diminished stem cells and defective enamel production.…”

Section: Epigenetic Regulation Of Stem Cells In the Incisormentioning

confidence: 99%

Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair

et al. 2022

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The homeostasis of adult tissues, such as skin, hair, blood, and bone, requires continuous generation of differentiated progeny of stem cells. The rodent incisor undergoes constant renewal and can provide an extraordinary model for studying stem cells and their progeny in adult tissue homeostasis, cell differentiation and injury-induced regeneration. Meanwhile, cellular heterogeneity in the mouse incisor also provides an opportunity to study cell-cell communication between different cell types, including interactions between stem cells and their niche environment. More importantly, the molecular and cellular regulatory mechanisms revealed by the mouse incisor have broad implications for other organs. Here we review recent findings and advances using the mouse incisor as a model, including perspectives on the heterogeneity of cells in the mesenchyme, the niche environment, and signaling networks that regulate stem cell behavior. The progress from this field will not only expand the knowledge of stem cells and organogenesis, but also bridge a gap between animal models and tissue regeneration.

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BMI1 in the heart: Novel functions beyond tumorigenesis

Cited by 14 publications

References 87 publications

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization

Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>

Rodent incisor as a model to study mesenchymal stem cells in tissue homeostasis and repair

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