Natural Compounds with BMI1 Promoter Inhibitory Activity from &lt;i&gt;Mammea siamensis&lt;/i&gt; and &lt;i&gt;Andrographis paniculata&lt;/i&gt;

Fujii, Kazuki; Hara, Yukio; Arai, Midori A.; Sadhu, Samir Kumar; Ahmed, Firoj; Ishibashi, Masami

doi:10.1248/cpb.c22-00556

Cited by 2 publications

(2 citation statements)

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“…T. Anders., which is the name recorded by the World Flora Online [ 6 ], is a small evergreen tree with fragrant yellow or white flowers distributed throughout Thailand (locally known as Sarapi or Saraphi), Laos, Cambodia, Vietnam, and Myanmar [ 7 , 8 , 9 , 10 , 11 ]. In Thailand, the flower part of this medicinal plant has been used as a heart tonic for lowering fever, and for boosting appetite [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, several coumarin [ 9 , 10 , 11 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ], xanthone [ 8 , 10 , 17 , 21 ], flavonoid [ 7 , 23 ], triterpene [ 10 , 12 ], and steroid [ 10 , 12 , 24 ] constituents have been reported from the flowers [ 7 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 20 , 23 , 24 ], seeds [ 18 , 21 ], twigs [ 8 , 17 , 19 ], and bark [ 22 ] of M. siamensis . This plant and its constituents have been reported to possess anti-proliferative and apoptotic activities [ 9 , 13 , 22 , 23 , 24 ], B-cell-specific Moloney murine leukemia virus insertion ...…”

Section: Introductionmentioning

confidence: 99%

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Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP

et al. 2023

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A methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) showed anti-proliferative activity against human prostate carcinoma LNCaP cells (IC50 = 2.0 µg/mL). Two new coumarin-related polysubstituted benzofurans, mammeasins P (1) and Q (2), and a known polysubstituted coumarin mammea B/AC cyclo F (39) were isolated from the extract along with 44 previously reported polysubstituted coumarin constituents (3–38 and 40–47). The structures of two new compounds (1 and 2) were determined based on their spectroscopic properties derived from the physicochemical evidence including NMR and MS analyses and taking the plausible generative pathway into account. Among the coumarin constituents, mammeasins A (3, IC50 = 1.2 µM) and B (4, 0.63 µM), sugangin B (18, 1.5 µM), kayeassamins E (24, 3.0 µM) and G (26, 3.5 µM), and mammeas E/BA (40, 0.88 µM), E/BB (41, 0.52 µM), and E/BC (42, 0.12 µM) showed relatively potent anti-proliferative activity.

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