Wind angles affect building’s natural ventilation and also energy consumption of the building. In winter, the wind direction in the outdoor environment will affect heat loss of the building, while in summer the change of wind direction and speed in the outdoor environment will affect the building’s ventilation and indoor air circulation. So, making a good deal with the issue of the angle between local buildings and the dominant wind direction can effectively solve the winter and summer ventilation problems. Thereby, it can enhance the comfort of residential person, improve indoor air quality, solve heat gain and heat loss problems in winter and summer in the severely cold and cold regions, and reduce building energy consumption. The simulation software CFD and energy simulation software are used in the paper. South direction of the building is the prototype of the simulation. The angle between the direction of the building and the outdoor environment wind is changed sequentially. Energy consumption under different wind angle conditions is compared with each other. Combined with natural ventilation under various wind angles, the paper gives the best recommended solution of building direction in Shenyang.