Blueberry extract promotes longevity and stress tolerance<i>via</i>DAF-16 in<i>Caenorhabditis elegans</i>

Wang, Huailing; Liu, Jie; Li, Tong; Liu, Rui Hai

doi:10.1039/c8fo01680a

Cited by 94 publications

(94 citation statements)

References 30 publications

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“…It was suggested that 2% pasteurized "Cara Cara" orange juice increased the mean lifespan of C. elegans by up to 29.5% compared to the untreated group [26]. Some investigators claim that the synergistic interactions among various compounds make the whole food elicit the maximum anti-aging effect [11]. In our previous study, Vayndorf et al found that whole apple extract extended C. elegans mean lifespan by 39%, which was greater than its major compounds, like quercetin (up to a 15% increase in the mean lifespan of C. elegans) and Epigallocatechin gallate (EGCG) (up to a 10% increase in the mean lifespan of C. elegans) [27].…”

Section: Discussionmentioning

confidence: 99%

“…Wild-type N2 C. elegans were cultivated on nematode growth medium (NGM) with living E.coli OP 50 as a food resource and incubated at 20 • C by referring to the methods in our laboratory [11]. A bleaching buffer containing 5% NaClO and 5 M NaOH was used to lyse gravid adult worms to release eggs.…”

Section: Elegans Cultivationmentioning

confidence: 99%

“…In addition, antioxidants that are able to scavenge overproduced radicals may extend the lifespan and delay the deterioration of aging [10]. A previous report showed that phytochemicals extracted from blueberry could promote stress tolerance and longevity via dauer formation (DAF)-16 in C. elegans [11]. Anacardium occidentale leaf extracts containing a number of polyphenolic antioxidants enhanced the survival rate of nematodes under oxidative stress via the DAF-16/FOXO (Forkhead box O) and SKN-1/Nrf-2 (Nuclear factor erythroid 2-related factor 2) signaling pathways [3].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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Orange, with various bioactive phytochemicals, exerts various beneficial health effects, including anti-cancer, antioxidant, and anti-inflammatory properties. However, its anti-aging effects remain unclear. In this study, the Caenorhabditis elegans (C. elegans) model was used to evaluate the effects of orange extracts on lifespan and stress resistance. The results indicated that orange extracts dose-dependently increased the mean lifespan of C. elegans by 10.5%, 18.0%, and 26.2% at the concentrations of 100, 200, and 400 mg/mL, respectively. Meanwhile, orange extracts promoted the healthspan by improving motility, and decreasing the accumulation of age pigment and intracellular reactive oxygen species (ROS) levels without damaging fertility. The survival rates of orange extract-fed worms were obviously higher than those of untreated worms against thermal and ultraviolet-B (UV-B) stress. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were significantly enhanced while malondialdehyde (MDA) contents were diminished. Further investigation revealed that worms supplemented with orange extracts resulted in upregulated levels of genes, including daf-16, sod-3, gst-4, sek-1, and skn-1, and the downregulation of age-1 expression. These findings revealed that orange extracts have potential anti-aging effects through extending the lifespan, enhancing stress resistance, and promoting the healthspan.

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Section: Discussionmentioning

confidence: 99%

Section: Elegans Cultivationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

et al. 2020

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“…Similarly, the anti-aging effect of myricetin was partly dependent on DAF-16 through a nuclear translocation of DAF-16, but not of SKN-1 [16]. Previously, our lab [17] reported that blueberry extract rich in polyphenols extended lifespan and increased survival rates after acute stress through the regulation of downstream gene of daf-16 in C. elegans. Besides, the oxidative stress resistance promoted by pasteurized orange juice (POJ) treatment in C. elegans has been reported as a result of the transcription factor SKN-1 action [18].…”

Section: Introductionmentioning

confidence: 87%

Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans

Yang

Wang

et al. 2020

IJMS

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Nobiletin (NOB), one of polymethoxyflavone existing in citrus fruits, has been reported to exhibit a multitude of biological properties, including anti-inflammation, anti-oxidation, anti-atherosclerosis, neuroprotection, and anti-tumor activity. However, little is known about the anti-aging effect of NOB. The objective of this study was to determine the effects of NOB on lifespan, stress resistance, and its associated gene expression. Using Caenorhabditis elegans, an in vivo nematode model, we found that NOB remarkably extended the lifespan; slowed aging-related functional declines; and increased the resistance against various stressors, including heat shock and ultraviolet radiation. Also, NOB reduced the effects of paraquat stressor on nematodes and scavenged reactive oxygen species (ROS). Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1. In summary, NOB has potential application in extension of lifespan, and its associated healthspan and stress resistances.

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“…increased the lifespan of C. elegans in a dose-dependent manner, reduced lipofuscin accumulation and ROS production, increased the activity of SOD, and diminished the levels of malondialdehyde (MDA). In addition, the extract increased stress tolerance by inducing the expression of genes related to antioxidant defense, including cat-1, sod-3, daf-16, mev-1, skn-1, mek-1, and nhr-8 [179]. The use of RNAi to inhibit the transcription factor DAF-16 reduced lifespan and reduced the expression of the sod-3.…”

Section: Plant Compounds and Longevitymentioning

confidence: 99%

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

Azzini²,

et al. 2020

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Plants and their corresponding botanical preparations have been used for centuries due to their remarkable potential in both the treatment and prevention of oxidative stress-related disorders. Aging and aging-related diseases, like cardiovascular disease, cancer, diabetes, and neurodegenerative disorders, which have increased exponentially, are intrinsically related with redox imbalance and oxidative stress. Hundreds of biologically active constituents are present in each whole plant matrix, providing promissory bioactive effects for human beings. Indeed, the worldwide population has devoted increased attention and preference for the use of medicinal plants for healthy aging and longevity promotion. In fact, plant-derived bioactives present a broad spectrum of biological effects, and their antioxidant, anti-inflammatory, and, more recently, anti-aging effects, are considered to be a hot topic among the medical and scientific communities. Nonetheless, despite the numerous biological effects, it should not be forgotten that some bioactive molecules are prone to oxidation and can even exert pro-oxidant effects. In this sense, the objective of the present review is to provide a detailed overview of plant-derived bioactives in age-related disorders. Specifically, the role of phytochemicals as antioxidants and pro-oxidant agents is carefully addressed, as is their therapeutic relevance in longevity, aging-related disorders, and healthy-aging promotion. Finally, an eye-opening look into the overall evidence of plant compounds related to longevity is presented.

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Blueberry extract promotes longevity and stress toleranceviaDAF-16 inCaenorhabditis elegans

Abstract: Blueberry is rich in bioactive phytochemicals with a wide of range of biological activities and health benefits.

Cited by 94 publications

References 30 publications

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans

Plant-Derived Bioactives and Oxidative Stress-Related Disorders: A Key Trend towards Healthy Aging and Longevity Promotion

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