Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide

Spohr, Luíza; Luduvico, Karina Pereira; Soares, Mayara Sandrielly Pereira; Bona, Natália Pontes; Oliveira, Pathise Souto; Mello, Julia Eisenhardt de; Alvez, Fernando Lopez; Teixeira, Fernanda Cardoso; Felix, Anelize de Oliveira Campello; Stefanello, Francieli Moro; Spanevello, Rosélia Maria

doi:10.1080/1028415x.2020.1819104

Cited by 19 publications

(17 citation statements)

References 67 publications

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“…Conversely, pretreatment with FLX and blueberry extract at both doses mitigated the depressive-like behavior induced by LPS, as pretreatment revealed a significant reduction in immobility time in the tail suspension test. Notably, recent studies have reported the potential of blueberry extract to prevent depressive-like behavior induced by animal models of metabolic syndrome (Oliveira et al, 2017) and in LPS-challenged mice (Spohr et al, 2020). Additionally, Oliveira et al (2017) have reported that, in a metabolic syndrome model, blueberry extract attenuated lipid peroxidation induced in the cerebral cortex and hippocampus of mice, contributing to the prevention of depressive-like behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, Oliveira et al (2017) have reported that, in a metabolic syndrome model, blueberry extract attenuated lipid peroxidation induced in the cerebral cortex and hippocampus of mice, contributing to the prevention of depressive-like behavior. Furthermore, Spohr et al (2020) have suggested that blueberry extract prevents depressive-like behavior by modulating oxidative stress parameters and tumor necrosis factorα levels in the mouse brain.…”

Section: Discussionmentioning

confidence: 99%

“…Behavioral assessments were performed 24 hr after vehicle or LPS administration (Figure 1). Fluoxetine, blueberry extract, and LPS dosage were selected based on previous reports (Spohr et al, 2020). After behavioral tests, animals were euthanized by deepening anesthetic with isoflurane, and then the blood was collected by cardiac puncture for biochemical analysis.…”

Section: Experimental Model Of Lps-challenge and Prevention Protocol With Blueberry Extractmentioning

confidence: 99%

“…The number of quadrants crossed during 5 min was used to assess locomotor activity. The apparatus was cleaned with 40% ethanol after each session (Spohr et al, 2019(Spohr et al, , 2020.…”

Section: Open-field Testmentioning

confidence: 99%

“…In this context, blueberry (Vaccinium virgatum), which is abundant in bioactive compounds, is known to possess a high concentration of total polyphenols; among these, anthocyanins (Ma et al, 2018) are phytochemicals with antiinflammatory, antioxidant, and neuroprotective activities (Silva et al 2018, Miller et al, 2019. Thus, a balanced diet associated with frequent polyphenol consumption has been effective in preventing numerous pathologies, including neuropsychiatric diseases (Debom et al, 2016;Spohr et al, 2019Spohr et al, , 2020.…”

Section: Introductionmentioning

confidence: 99%

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Effect of blueberry ( Vaccinium virgatum ) extract on depressive‐like behavior and metabolic serum alterations in lipopolysaccharide‐challenged mice

et al. 2021

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In the present study, we aimed to investigate the protective effect of blueberry extract on behavioral, biochemical, and morphological changes in an experimental model of lipopolysaccharide (LPS)-induced depressive behavior. Male Swiss mice were pretreated with the vehicle, fluoxetine (20 mg/kg), or Vaccinium virgatum extract (100 mg/kg and 200 mg/kg) for seven days. On day 7, the animals were administered an LPS injection (0.83 mg/kg) or vehicle. Pretreatment with blueberry extract prevented LPS-induced depressive-like behavior. Moreover, LPS increased serum levels of total cholesterol; however, V. virgatum did not prevent the increase in total cholesterol levels. Furthermore, the extract prevented the LPS-induced elevation in serum reactive oxygen species. Also, V. virgatum extract increased the HDL cholesterol levels. Additionally, this extract prevented the LPS-induced decrease in glucose levels and serum adenosine deaminase activity. Collectively, V. virgatum extract has a potential protective effect against changes similar to those observed in patients with depression. Practical applicationsVaccinium virgatum, popularly known as blueberry, has been effective in preventing or treating neuropsychiatric diseases owing to its antioxidant, anti-inflammatory, and neuroprotective properties. Fluoxetine is a known drug used to treat depression; however, its adverse effects result in therapeutic non-adherence. Thus, the search for new natural compounds possessing antidepressant activities while lacking adverse effects is crucial for identifying novel therapeutic alternatives against depression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Model Of Lps-challenge and Prevention Protocol With Blueberry Extractmentioning

confidence: 99%

“…The number of quadrants crossed during 5 min was used to assess locomotor activity. The apparatus was cleaned with 40% ethanol after each session (Spohr et al, 2019(Spohr et al, , 2020.…”

Section: Open-field Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of blueberry ( Vaccinium virgatum ) extract on depressive‐like behavior and metabolic serum alterations in lipopolysaccharide‐challenged mice

et al. 2021

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Identification, quantification, and antidepressant‐like evaluation of anthocyanin‐rich extracts from different dietary berries

Wang,

Cheng,

Zhu

et al. 2024

Food Science & Nutrition

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Berries are highly valued for their rich phenolic content, particularly anthocyanins, which are known for their antioxidative properties and potential effectiveness against depression. This study identified and quantified anthocyanin profiles in blueberry, blackberry, black mulberry, and cranberry using ultra‐performance liquid chromatography–mass spectrometry (UPLC–MS), followed by in vivo evaluation of their antidepressant‐like activities. Blueberry and black mulberry showed significant levels of cyanidin‐3‐galactoside and cyanidin. Acute supplementation with these berries decreased serum corticosterone levels and increased monoamine neurotransmitters, while chronic supplementation enhanced antioxidative activity and reduced neuroinflammation in the hippocampus of mice. These findings indicate that the neurochemical, antioxidative, and anti‐inflammatory effects of blueberry and black mulberry mediate their therapeutic role against depression. Berries rich in cyanidin‐3‐galactoside and cyanidin may be valuable in developing functional foods, dietary supplements, and pharmacological formulations for mental health improvement.

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Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status

et al. 2021

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Blueberry extract as a potential pharmacological tool for preventing depressive-like behavior and neurochemical dysfunctions in mice exposed to lipopolysaccharide

Cited by 19 publications

References 67 publications

Effect of blueberry ( Vaccinium virgatum ) extract on depressive‐like behavior and metabolic serum alterations in lipopolysaccharide‐challenged mice

Effect of blueberry ( Vaccinium virgatum ) extract on depressive‐like behavior and metabolic serum alterations in lipopolysaccharide‐challenged mice

Identification, quantification, and antidepressant‐like evaluation of anthocyanin‐rich extracts from different dietary berries

Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status

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