Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status

Silveira, L. M.; Pedra, Nathália Stark; Bona, Natália Pontes; Spohr, Luíza; Santos, Francieli da Silva dos; Saraiva, Juliane Torchelsen; Alvez, Fernando Lopez; Meine, Bernardo de Moraes; Spanevello, Rosélia Maria; Stefanello, Francieli Moro; Soares, Mayara Sandrielly Pereira

doi:10.1007/s11011-021-00867-5

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…The possible effects of polyphenols on ROS have already been reported which included increased free radical scavenging activity, positive modulation of the antioxidant enzymes, SOD and CAT, and modulation of the expression of transcription factors. [66][67][68] The present study investigated the efficacy of ZO supplementation in ameliorating the behavioral deficits, biochemical alterations and histological changes associated with infliction of C6 glioma cells in the rat brain.…”

Section: Discussionmentioning

confidence: 99%

Understanding the role of zingerone on biochemical and behavioral changes in rat brain inflicted with C6 glioma cells

Chopra

Chadha

Dhawan

2023

J Biochem & Molecular Tox

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Malignant glioma is the deadliest form of brain cancer. Zingerone (ZO), a polyphenolic compound found in ginger, offers pharmacological properties that make it a promising agent for containing the growth of glioma cells. The present study was conducted to understand the efficacy of ZO in containing the growth of C6 glioma cells. The study also assessed the prophylactic role of ZO on rat brain glioma induced by C6 cell lines by addressing its antioxidative action on biochemical, behavioral, and histoarchitectural indices. For dose optimization, the animals were pretreated with different doses of ZO for a period of 2 weeks before the inoculation of glioma cells (1 × 105/10 µL phosphate‐buffered saline) in the caudate region of rat brain and the treatment with ZO continued for 4 more weeks post implantation. In vitro studies were done to assess the radical scavenging activity of ZO and also to determine its effects on viability of C6 glioma cells at different concentrations. Glioma‐bearing rats showed significant alterations in memory; exploratory and muscular activities which were appreciably improved upon simultaneous supplementation of ZO administered at a dose of 50 mg/kg body weight and were also visible even at a higher dose. Glioma‐bearing rats revealed a significant increase in reactive oxygen species, protein carbonyl contents, and lipid peroxidation, but showed a significant decrease in reduced glutathione and antioxidative enzymes in the brain tissue. Interestingly, all the biochemical indices and altered brain histoarchitecture displaying cellular atypia and hyperplasia showed appreciable improvement when supplemented with ZO at a dose of 50 mg/kg body weight.

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Section: Discussionmentioning

confidence: 99%

Understanding the role of zingerone on biochemical and behavioral changes in rat brain inflicted with C6 glioma cells

Chopra

Chadha

Dhawan

2023

J Biochem & Molecular Tox

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“…↓ viability, proliferation, migration and invasion of HSC-3 cells and tumor area in zebrafish [179] Blueberry extract Cancer In vitro (C6 rat glioma cell line) ↓ viability, proliferation, size of the colonies and cell migration [180] Crataegus berry extract Cancer In vitro (highly aggressive human glioblastoma U87MG cell line)…”

Section: Elderberry Extract Immune Systemmentioning

confidence: 99%

Recent Studies on Berry Bioactives and Their Health-Promoting Roles

et al. 2021

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Along with the increased knowledge about the positive health effects of food bioactives, the eating habits of many individuals have changed to obtain higher nutritional benefits from foods. Fruits are among the most preferred food materials in this regard. In particular, berry fruits are important sources in the diet in terms of their high nutritional content including vitamins, minerals, and phenolic compounds. Berry fruits have remedial effects on several diseases and these health-promoting impacts are associated with their phenolic compounds which may vary depending on the type and variety of the fruit coupled with other factors including climate, agricultural conditions, etc. Most of the berries have outstanding beneficial roles in many body systems of humans such as gastrointestinal, cardiovascular, immune, and nervous systems. Furthermore, they are effective on some metabolic disorders and several types of cancer. In this review, the health-promoting effects of bioactive compounds in berry fruits are presented and the most recent in vivo, in vitro, and clinical studies are discussed from a food science and nutrition point of view.

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Insights on Dietary Anticancer Products: Food Supplements, Prebiotics, and Probiotics

Elhawary,

Korany,

Eldahshan

et al. 2024

Interdisciplinary Cancer Research

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Selective in vitro anticancer effect of blueberry extract (Vaccinium virgatum) against C6 rat glioma: exploring their redox status

Cited by 3 publications

References 66 publications

Understanding the role of zingerone on biochemical and behavioral changes in rat brain inflicted with C6 glioma cells

Understanding the role of zingerone on biochemical and behavioral changes in rat brain inflicted with C6 glioma cells

Recent Studies on Berry Bioactives and Their Health-Promoting Roles

Insights on Dietary Anticancer Products: Food Supplements, Prebiotics, and Probiotics

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