Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage

Ahmet, Ismayil; Spangler, Edward L.; Shukitt‐Hale, Barbara; Juhaszova, Magdalena; Sollott, Steven J.; Joseph, James A.; Ingram, Donald K.; Talan, Mark I.

doi:10.1371/journal.pone.0005954

Cited by 58 publications

(42 citation statements)

References 51 publications

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“…ROS formation is triggered by the depletion of ATP and an overload of Ca 2+ [4,5] . It was originally believed that ROS formation occurs primarily, or even exclusively, during reperfusion, when oxygen interacts with the damaged mitochondrial respiratory chain [6] . Chen et al [3] showed that ROS may affect intercellular connections and cytoskeleton resulting in cell detachment, morphology change, or death.…”

mentioning

confidence: 99%

The Protective Effect of INH<sub>2</sub>BP, a Novel PARP Inhibitor 5-Iodo-6-Amino-1,2-Benzopyrone, Against Hydrogen Peroxide-Induced Apoptosis Through ERK and p38 MAPK in H9c2 Cells

et al. 2015

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INH₂BP (5-iodo-6-amino-1,2-benzopyrone), a poly-ADP ribose polymerase inhibitor, has been shown to possess anti-cancer, anti-viral, and anti-inflammation properties. The aim of this study was to investigate the protective effect of INH₂BP against oxidative stress-induced apoptosis in H9c2 cardiomyoblast cells. While the treatment of H9c2 cardiomyoblasts cells with hydrogen peroxide (H₂O₂) caused a loss of cell viability and an increase in the number of apoptotic cells, INH₂BP significantly protected the cells against H₂O₂-induced cell death without any cytotoxicity. Our data also shows that INH₂BP significantly scavenged intracellular reactive oxygen species (ROS), and markedly enhanced the expression of antioxidant enzymes such as Mn-SOD (superoxide) and Cu/Zn-SOD, and heme oxygenase-1, which was accompanied by the concomitant activation of extracellular regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) phosphorylation in H9c2 cells. The effects of INH₂BP on ERK1/2 and p38 MAPK phosphorylation were abrogated by PD98059, an ERK1/2 inhibitor, and SB203580, a p38 inhibitor. In addition, inhibition of ERK1/2 and p38 MAPK by these inhibitors significantly attenuated INH₂BP-mediated H9c2 viability as well as cleaved caspases-3, Bax, and Bcl-2 activation. Taken together, these results demonstrate that INH₂BP prevents H₂O₂-induced apoptosis in H9c2 cells by reducing the production of intracellular ROS, regulating apoptotic-related proteins, and the activation of the ERK1/2 and p38 MAPK.

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confidence: 99%

The Protective Effect of INH<sub>2</sub>BP, a Novel PARP Inhibitor 5-Iodo-6-Amino-1,2-Benzopyrone, Against Hydrogen Peroxide-Induced Apoptosis Through ERK and p38 MAPK in H9c2 Cells

et al. 2015

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“…Male BALB/c mice Oral: 1.62 g/mouse # MDA, # mucosal injury in the ileum [114] Cooked navy and black bean anthocyanins "histological injury score and apoptosis, "serum ORAC, reversed splenic tissue weight increase [164] Black raspberry anthocyanins Fruit DSS-induced UC C57BL/6J male mice Oral: 5% black raspberry diets # Staining of macrophages and neutrophils, # NF-kB p65 nuclear localization in the colon, # ulceration in the mucosa, submucosa and muscularis on day 28, # protein expression of DNMT3B, HDAC1, HDAC2 and MBD2, # HDAC1 mRNA expression in spleen, # mRNA expression of DNMT3B, HDAC1, HDAC2 and MBD2 in bone marrow, "methylation and mRNA expression of dkk3, dkk2 and apc, # b-catenin nuclear localization [155] Black raspberry anthocyanins Dietary anthocyanins as a complementary medicinal approach for management of IBD Review informahealthcare.com from nephropathy [88], antioxidative effects [89,90], antiinflammatory activities [91], antiobesity [92], antidiabetic, vision improvement properties, inhibition of carcinogenesis and mutagenesis [93]. An in vivo research showed that wildblueberry-enriched diet improved the proinflammatory status associated with metabolic syndrome in the obese Zucker rat with decreased liver expression of NF-kB, C-reactive protein, IL-6 and increased adiponectin expression [94].…”

Section: Fruit Intestinal Oxidative Stress Induced By Ischemia Reperfmentioning

confidence: 99%

Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

Sodagari

Farzaei

Bahramsoltani

et al. 2015

Expert Review of Gastroenterology & Hepatology

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Inflammatory bowel disease (IBD) is thought to result from a chronic or relapsing activation of the immune system in the GI tract. A growing body of evidence confirms the health benefits of dietary anthocyanins as plant-derived natural agents. The aim of this review is to provide an overview of several natural products rich in anthocyanins used worldwide for the treatment of IBD. Anthocyanins possess both protective and therapeutic functions in the management of IBD by alleviating oxidative stress processes, cytoprotective functions, downregulation of inflammatory cytokines and suppressing cellular signaling pathways of inflammatory processes. In conclusion, the consumption of anthocyanin-rich natural formulations must be promoted on the basis of their possible function in the prevention and treatment of gastrointestinal inflammatory disorders.

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“…Several studies have provided evidences of anti-inflammatory (Ahmet et al, 2009;Lau et al, 2007), antihypertensive (Johnson et al, 2015;Kalea et al, 2009;Shaughnessy et al, 2009), antiobesity (Prior et al, 2009) andantidiabetic (DeFuria et al, 2009;Stull et al, 2010) effects of BB.…”

Section: Introductionmentioning

confidence: 99%

14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model

Ströher¹,

Piccoli²,

Güllich³

et al. 2015

International Journal of Food Sciences and Nutrition

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The effects of supplementation with blueberry (BE) extract (Vaccinium ashei Reade) for 14 consecutive days on biochemical, hematological, histopathological and oxidative parameters in hypercholesterolemic rats were investigated. After supplementation with lyophilized extract of BE, the levels of total cholesterol, low-density lipoprotein cholesterol and triglycerides were decreased. Histopathological analysis showed significant decrease (p < 0.05) of aortic lesions in hypercholesterolemic rats. Oxidative parameters showed significant reductions (p < 0.05) in oxidative damage to lipids and proteins and an increase in activities of antioxidant enzymes such as catalase, superoxide dismutase and glutathione peroxidase. The BE extract showed an important cardioprotective effect by the improvements in the serum lipid profile, antioxidant system, particularly in reducing oxidative stress associated with hypercholesterolemia and anti-atherogenic effect in rats.

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Blueberry-Enriched Diet Protects Rat Heart from Ischemic Damage

Cited by 58 publications

References 51 publications

The Protective Effect of INH<sub>2</sub>BP, a Novel PARP Inhibitor 5-Iodo-6-Amino-1,2-Benzopyrone, Against Hydrogen Peroxide-Induced Apoptosis Through ERK and p38 MAPK in H9c2 Cells

The Protective Effect of INH<sub>2</sub>BP, a Novel PARP Inhibitor 5-Iodo-6-Amino-1,2-Benzopyrone, Against Hydrogen Peroxide-Induced Apoptosis Through ERK and p38 MAPK in H9c2 Cells

Dietary anthocyanins as a complementary medicinal approach for management of inflammatory bowel disease

14 Days of supplementation with blueberry extract shows anti-atherogenic properties and improves oxidative parameters in hypercholesterolemic rats model

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