Blueberry, combined with probiotics, alleviates non-alcoholic fatty liver disease<i>via</i>IL-22-mediated JAK1/STAT3/BAX signaling

Zhu, Juanjuan; Zhou, Mingyu; Zhao, Xueke; Mu, Mao; Cheng, Mingliang

doi:10.1039/c8fo01227j

Cited by 25 publications

(17 citation statements)

References 30 publications

(29 reference statements)

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“…The main composition of blueberry juice was detected as described in the previous study. 15 As shown in our previous study, 16 the anthocyanin concentration in blueberry juice was 0.98 ± 0.07 mg mL −1 . Dry probiotic tablets mixed with the probiotic species of Bifidobacterium infantis, Bifidobacterium animalis, and Lactobacillus acidophilus were obtained from the China General Microbiological Culture Collection Center (Beijing, China).…”

Section: Preparation Of Bpmentioning

confidence: 60%

Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease

et al. 2019

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Section: Preparation Of Bpmentioning

confidence: 60%

Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease

et al. 2019

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“…Contrarily, the anti-inflammatory effect was less pronounced in some animal studies and human [21, 36, 37]. New reports indicated that blueberry extracts can significantly inhibit inflammatory and apoptosis via activation of JAK1/STAT3 signaling [38], PPARγ activity [39] or survival PI3K/Akt and MAPK/ERK pathways [40].…”

Section: Discussionmentioning

confidence: 99%

Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse

et al. 2019

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Background Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to determine how blueberry affects glucose metabolism and pancreatic β-cell proliferation in high fat diet (HFD)-induced obese mice. Methods Wild type male mice at age of 4 weeks received two different kinds of diets: high-fat diet (HFD) containing 60% fat or modified HFD supplemented with 4% (wt:wt) freeze-dried whole blueberry powder (HFD + B) for 14 weeks. A separate experiment was performed in mice fed with low-fat diet (LFD) containing 10% fat or modified LFD + B supplemented with 4% (wt:wt) freeze-dried whole blueberry powder. The metabolic parameters including blood glucose and insulin levels, glucose and insulin tolerances were measured. Results Blueberry-supplemented diet significantly increased insulin sensitivity and glucose tolerance in HFD + B mice compared to HFD mice. However, no difference was observed in blood glucose and insulin sensitivity between LFD + B and LFD mice. In addition, blueberry increased β-cell survival and prevented HFD-induced β-cell expansion. The most important finding was the observation of presence of small scattered islets in blueberry treated obese mice, which may reflect a potential role of blueberry in regenerating pancreatic β-cells. Conclusions Blueberry-supplemented diet can prevent obesity-induced insulin resistance by improving insulin sensitivity and protecting pancreatic β-cells. Blueberry supplementation has the potential to protect and improve health conditions for both type 1 and type 2 diabetes patients. Electronic supplementary material The online version of this article (10.1186/s12986-019-0363-6) contains supplementary material, which is available to authorized users.

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“…The binding of IL-22 to IL-22R activates downstream signal transduction (Figure 1) (39). IL-22 transmits phosphorylation signals downstream through Janus kinase (JAK) 1 and tyrosine kinase (TYK) 2, including the mitogen-activated protein kinase (MAPK) pathway (p38 kinase, ERK1/2, MEK1/2 and JNK), STAT3, STAT1 and STAT5 (39)(40)(41). Similar to other members of the IL-10 family, IL-22 phosphorylates STAT3 mainly at Ser727 and Tyr705 (23,42,43).…”

Section: Characteristics Of Th22 Cellsmentioning

confidence: 99%

Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

et al. 2021

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Upon antigenic stimulation, naïve CD4+T cells differentiate into different subsets and secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+T cell subset,are distinct from the Th1, Th2 and Th17 subsets. Th22 cells secrete certain cytokines such as IL-22, IL-13 and TNF-α, but not others, such as IL-17, IL-4, or interferon-γ (IFN-γ), and they express chemokine receptors CCR4, CCR6 and CCR10. Th22 cells were initially found to play a role in skin inflammatory diseases, but recent studies have demonstrated their involvement in the development of various autoimmune diseases. Here, we review research advances in the origin, characteristics and effector mechanisms of Th22 cells, with an emphasis on the role of Th22 cells and their main effector cytokine IL-22 in the pathogenesis of autoimmune diseases. The findings presented here may facilitate the development of new therapeutic strategies for targeting these diseases.

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Blueberry, combined with probiotics, alleviates non-alcoholic fatty liver diseaseviaIL-22-mediated JAK1/STAT3/BAX signaling

Abstract: Blueberry, combined with probiotics, improves non-alcoholic fatty liver disease bothin vivoandin vitroby IL-22.

Cited by 25 publications

References 30 publications

Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease

Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease

Whole blueberry protects pancreatic beta-cells in diet-induced obese mouse

Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

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