Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

Jiang, Qi; Yang, Guocan; Xiao, Fan; Xie, Jue; Wang, Shengjun; Lü, Lei; Cui, Dawei

doi:10.3389/fimmu.2021.688066

Cited by 75 publications

(73 citation statements)

References 152 publications

(201 reference statements)

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“…Moreover, periodontal pathogens also have an ability to induce a stronger Th1 and Th17 response (Monasterio et al, 2018;Bittner-Eddy et al, 2020). Th22 cells, a new type of characterized CD4 + T cells with IL22 as the main cytokines, are associated with the pathogenesis of autoimmune diseases (Jiang et al, 2021). A positive relationship exists between Th22 and Th17 in T1D patients and Th22 might contribute to the onset of T1D (Xu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Ectopic Colonization and Immune Landscapes of Periodontitis Microbiota in Germ-Free Mice With Streptozotocin-Induced Type 1 Diabetes Mellitus

Shen

Wei

et al. 2022

Front. Microbiol.

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A two-way relationship between diabetes and periodontitis has been discussed recently. Periodontitis microbiota might affect the immune homeostasis of diabetes, but the molecular mechanism of their interactions is still not clear. The aims of this study were to clarify the possible immune regulatory effects of periodontitis microbiota on diabetes and the correlation between immunomodulation and ectopic colonization. A model of germ-free mice with streptozotocin-induced type 1 diabetes mellitus (T1D), which was orally inoculated with mixed saliva samples for 2 weeks, was used in this study. Those mice were randomly divided into two groups, namely, SP (where the T1D mice were orally inoculated with mixed saliva samples from periodontitis patients) and SH (where the T1D mice were orally inoculated with mixed saliva samples from healthy subjects). Ectopic colonization of saliva microbiota was assessed using culture-dependent method and Sanger sequencing, and the composition of gut microbiota was analyzed using 16S rRNA gene sequencing. Changes in 15 types of immune cells and six cytokines either from the small intestine or spleen were detected by multicolor flow cytometry. The correlation between gut microbiota and immune cells was evaluated by redundancy analysis. Although periodontitis microbiota minorly colonized the lungs, spleens, and blood system, they predominantly colonized the gut, which was mainly invaded by Klebsiella. SH and SP differed in beta diversity of the gut bacterial community. Compared to SH, microbial alteration in small intestine occurred with an increase of Lacticaseibacillus, Bacillus, Agathobacter, Bacteroides, and a decrease of Raoultella in SP. More types of immune cells were disordered in the spleen than in the small intestine by periodontitis microbiota, mainly with a dramatical increase in the proportion of macrophages, plasmacytoid dendritic cells (pDCs), monocytes, group 3 innate lymphoid cells, CD4-CD8- T cells and Th17 cells, as well as a decline of αβT cells in SP. Cytokines of IFNγ, IL17, and IL22 produced by CD4 + T cells as well as IL22 produced by ILCs of small intestine rose in numbers, and the intestinal and splenic pDCs were positively regulated by gut bacterial community in SP. In conclusion, periodontitis microbiota invasion leads to ectopic colonization of the extra-oral sites and immune cells infiltration, which might cause local or systemic inflammation. Those cells are considered to act as a “bridge” between T1D and periodontitis.

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Section: Discussionmentioning

confidence: 99%

Ectopic Colonization and Immune Landscapes of Periodontitis Microbiota in Germ-Free Mice With Streptozotocin-Induced Type 1 Diabetes Mellitus

Shen

Wei

et al. 2022

Front. Microbiol.

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“…Studies have revealed that Th22 cells play a regulatory role in the pathogenesis of varied immune disorders, infections, and tumors ( 14 , 15 , 21 , 22 , 142 , 143 ). Here, we provided a brief summary of published research pertaining to the roles of Th22 cells in skin diseases.…”

Section: The Roles Of Th22 Cells In Skin Diseasesmentioning

confidence: 99%

“…Th22 cells have been proposed to play essential roles in autoimmune diseases including rheumatoid arthritis, inflammatory bowel diseases, asthma, multiple sclerosis, immune thrombocytopenia, nephropathy, hepatitis, thyroid diseases, and myasthenia gravis, as well as infectious diseases and tumors (14)(15)(16)(17)(18)(19)(20)(21)(22). Recently, emerging advances regarding the understanding of Th22 cells are allowing in-depth comprehension of the cutaneous immune system, which might promote the development of treatments targeting Th22 cells.…”

Section: Introductionmentioning

confidence: 99%

The Role of T Helper 22 Cells in Dermatological Disorders

Pan

Wang

et al. 2022

Front. Immunol.

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T helper 22 (Th22) cells are a newly identified subset of CD4+ T cells that secrete the effector cytokine interleukin 22 (IL-22) upon specific antigen stimulation, barely with IFN-γ or IL-17. Increasing studies have demonstrated that Th22 cells and IL-22 play essential roles in skin barrier defense and skin disease pathogenesis since the IL-22 receptor is widely expressed in the skin, especially in keratinocytes. Herein, we reviewed the characterization, differentiation, and biological activities of Th22 cells and elucidated their roles in skin health and disease. We mainly focused on the intricate crosstalk between Th22 cells and keratinocytes and provided potential therapeutic strategies targeting the Th22/IL-22 signaling pathway.

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“…Increased production of IL-26 and IL-29 by Th17 stimulate further release of proinflammatory mediators which recruit Th1 cells into psoriatic skin lesions [ 37 , 38 ]. Increased production of IL-17 results in increased secretion of IL-19, IL-22, and IL-36 which also contribute to the development of epidermal hyperplasia [ 39 , 40 ]. IL-22 in psoriatic lesions is secreted not only by CD4 + and CD8 + T cells known as Th22 and Tc22 cells but also by Th17, mast cells, and others [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Psoriasis between Autoimmunity and Oxidative Stress: Changes Induced by Different Therapeutic Approaches

Medovic

Jakovljević

Živković

et al. 2022

Oxidative Medicine and Cellular Longevity

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Psoriasis is defined as chronic, immune-mediated disease. Regardless of the development of new therapeutic approaches, the precise etiology of psoriasis remains unknown and speculative. The aim of this review was to systematize the results of previous research on the role of oxidative stress and aberrant immune response in the pathogenesis of psoriasis, as well as the impact of certain therapeutic modalities on the oxidative status in patients with psoriasis. Complex immune pathways of both the innate and adaptive immune systems appear to be major pathomechanisms in the development of psoriasis. Oxidative stress represents another important contributor to the pathophysiology of disease, and the redox imbalance in psoriasis has been reported in skin cells and, systemically, in plasma and blood cells, and more recently, also in saliva. Current immune model of psoriasis begins with activation of immune system in susceptible person by some environmental factor and loss of immune tolerance to psoriasis autoantigens. Increased production of IL-17 appears to be the most prominent role in psoriasis pathogenesis, while IL-23 is recognized as master regulator in psoriasis having a specific role in cross bridging the production of IL-17 by innate and acquired immunity. Other proinflammatory cytokines, including IFN-γ, TNF-α, IL-1β, IL-6, IL-22, IL-26, IL-29, or IL-36, have also been reported to play important roles in the development of psoriasis. Oxidative stress can promote inflammation through several signaling pathways. The most noticeable and most powerful antioxidative effects exert various biologics compared to more convenient therapeutic modalities, such as methotrexate or phototherapy. The complex interaction of redox, immune, and inflammatory signaling pathways should be focused on further researches tackling the pathophysiology of psoriasis, while antioxidative supplementation could be the solution in some refractory cases of the disease.

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Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases

Cited by 75 publications

References 152 publications

Ectopic Colonization and Immune Landscapes of Periodontitis Microbiota in Germ-Free Mice With Streptozotocin-Induced Type 1 Diabetes Mellitus

Ectopic Colonization and Immune Landscapes of Periodontitis Microbiota in Germ-Free Mice With Streptozotocin-Induced Type 1 Diabetes Mellitus

The Role of T Helper 22 Cells in Dermatological Disorders

Psoriasis between Autoimmunity and Oxidative Stress: Changes Induced by Different Therapeutic Approaches

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