Blue Rubber Bleb Nevus Syndrome and Gastrointestinal Haemorrhage: Which Treatment?

Abstract

BRBNS belongs to the group of vascular venous malformations. Most of the time it occurs sporadically, but it can be inherited as an autosomal dominant trait. Recent analysis identified a locus on chromosome 9 responsible for venous malformations. BRBNS patients present typical skin lesions, with some lesions having a rubber-like nipple appearance; the number of skin and GI lesions and the severity of anaemia are correlated. Treatment is dependent on the extent of gut involvement and the severity of the clinical picture. In the absence of massive bleeding, a conservative treatment will be sufficient; otherwise resections are mandatory, but additional lesions may subsequently develop. Management with electrocautery or laser photocoagulation are usually not effective even if some reports recommend them. Pharmacological treatment is useless. Prognosis of BRBNS is unknown.

Radical resection of intestinal blue rubber bleb nevus syndrome

“…Blue rubber bleb nevus syndrome (BRBNS) is a rare systemic vascular disorder characterized by multiple venous malformations, such as hemangioma, involving many organs [1]. Approximately 200 cases of BRBNS including 13 Korean cases have been reported since Gascoyen's first presentation in 1860 [2].…”

Physical activity alters antioxidant status in exercising elderly subjects

“…In welltrained competitive athletes, antioxidant status is preserved by adequate dietary antioxidant intakes [8]. In EE subjects, changes in absorptive and metabolic capacity might influence their food choice and could lead to deficiencies in antioxidant vitamins and trace elements [9,10]. To date, recommended dietary allowances for EE subjects cannot be provided because there is still a substantial lack of data regarding exercise training effects in elderly subjects [11].…”

Use of Laparoscope as Rigid Enteroscope in Blue Rubber Bleb Naevus Syndrome

“…Medical therapies including the use of interferon, corticosteroids and antifibrinolytics have been largely unsuccessful. 7 Several interventional approaches have been reported in the literature. The use of endoscopy has been widely described.…”