Blue light kills Aggregatibacter actinomycetemcomitans due to its endogenous photosensitizers

Späth, Andreas; Leibl, Christoph; Gollmer, Anita; Regensburger, Johannes; Tabenski, Laura; Hiller, Karl‐Anton; Maisch, Tim; Schmalz, Gottfried

doi:10.1007/s00784-013-1151-8

Cited by 95 publications

(77 citation statements)

References 36 publications

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“…Cieplik et al treated another periodontal pathogen, Aggregatibacter actinomycetemcomitans , with aBL at 460 nm derived from a LED (Cieplik et al, 2014). The investigators observed a ≥ 5-log 10 reduction in CFU of A. actinomycetemcomitans in suspensions after an exposure of 150 J/cm 2 aBL, whereas no effect of aBL was found against E. coli at the same aBL exposure.…”

Section: Efficacy Of Antimicrobial Blue Light Inactivation Of Pathmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

208

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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Section: Efficacy Of Antimicrobial Blue Light Inactivation Of Pathmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

208

192

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“…A similar phenomenon has been found with A. actinomycetemcomitans in which blue light without sensitizer reduced the viable count of a suspension by 5 log 10 , which appeared to be due to endogenous flavin-like or porphyrin-like compounds. 58 In contrast there was no effect of blue light on Escherichia coli because no singlet oxygen species was generated presumably because no similar endogenous photosensitisers were detected. 58 Exploiting natural porphyrins as photosensitisers certainly has value if it can be successfully applied to subgingival plaque in patients with periodontitis.…”

Section: Selective Killingmentioning

confidence: 99%

“…58 In contrast there was no effect of blue light on Escherichia coli because no singlet oxygen species was generated presumably because no similar endogenous photosensitisers were detected. 58 Exploiting natural porphyrins as photosensitisers certainly has value if it can be successfully applied to subgingival plaque in patients with periodontitis. Indeed, light applied to the oral surfaces of periodontitis patients shows a selective reduction of 4 black-pigmented species.…”

Section: Selective Killingmentioning

confidence: 99%

Non-conventional therapeutics for oral infections

Allaker

Douglas

2015

Virulence

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“…However, the use of blue light for actual wound infections has not been established 15,16 . The majority of the publications on the anti-infective effect of blue light have been confined to in vitro studies [18][19][20][21][22][23][24][25][26] . There have been (rather surprisingly) only three published reports (preclinical reports all from our laboratory) to demonstrate the effectiveness of blue light for wound infections [27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial blue light therapy forCandida albicansburn infection in mice

Zhang

Wang

Murray³

et al. 2015

SPIE Proceedings

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In this preclinical study, we investigated the utility of antimicrobial blue light therapy for Candida albicans infection in acutely burned mice. A bioluminescent strain of C. albicans was used. The susceptibilities to blue light inactivation were compared between C. albicans and human keratinocyte. In vitro serial passaging of C. albicans on blue light exposure was performed to evaluate the potential development of resistance to blue light inactivation. A mouse model of acute thermal burn injury infected with the bioluminescent strain of C. albicans was developed. Blue light (415 nm) was delivered to mouse burns for decolonization of C. albicans. Bioluminescence imaging was used to monitor in real time the extent of fungal infection in mouse burns. Experimental results showed that C. albicans was approximately 42-fold more susceptible to blue light inactivation in vitro than human keratinocyte (P=0.0022). Serial passaging of C. albicans on blue light exposure implied a tendency for the fungal susceptibility to blue light inactivation to decrease with the numbers of passages. Blue light reduced fungal burden by over 4-log 10 (99.99%) in acute mouse burns infected with C. albicans in comparison to infected mouse burns without blue light therapy (P=0.015).

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Blue light kills Aggregatibacter actinomycetemcomitans due to its endogenous photosensitizers

Abstract: These results encourage further studies on the potential use of these blue light-mediated auto-photosensitization processes in the treatment of periodontitis for the successful inactivation of Aggregatibacter actinomycetemcomitans.

Cited by 95 publications

References 36 publications

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Non-conventional therapeutics for oral infections

Antimicrobial blue light therapy forCandida albicansburn infection in mice

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