Bloodstream infection in pediatric patients with febrile neutropenia induced by chemotherapy

Lima, Maria Luísa; Rodrigues, Karla Emília de Sá; Vanucci, Michelle Fonseca; Silva, Paula Larissa Lebron da; Baêta, Thaís; Oliveira, Iara Paiva; Romanelli, Roberta Maia de Castro

doi:10.1016/j.htct.2021.08.005

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…However, the trend seen in our region of the World is still predominantly gram-negative bacteremia. The lower use of long-term central venous catheters in developing nations compared to developed ones may be one of the reasons [10,11]. The reverse may also be true.…”

Section: Discussionmentioning

confidence: 99%

Bloodstream Infections in Paediatric Cancer Patients with Febrile Neutropenia in a Tertiary Cancer Centre in North-East India

Talukdar,

Barman,

Hazarika

et al. 2023

Asian Pac J Cancer Care

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Background: The aim of the present study was to study the pattern of microbial flora, their susceptibility patterns, and clinical variables among bloodstream infections in febrile neutropenic patients with solid tumors and hematological malignancies in the paediatric age group in North-East India. Methods: It was a retrospective and observational study done in a single tertiary care cancer centre in North-East India. The study period was from 1st January 2020 to 31st December 2021. The study population included all the patients below the age of 18 years who developed febrile neutropenia during treatment for a diagnosed cancer. Results: A total of 378 blood culture samples were studied. Febrile neutropenia was found in 252 patients (66.7%). There were 45 positive blood cultures (17.8%) among them. Gram-negative and gram-positive organisms accounted for 62% and 38% of all positive cultures respectively. Escherichia coli (39%) was the most common gram-negative isolate, followed by Klebsiella pneumoniae (32%), Pseudomonas aeruginosa (18%) and Acinetobacter baumannii (7%). Coagulase-negative Staphylococci (CoNS) was the most common gram-positive isolate (47%). Sensitivity to beta-lactam/beta-lactamase inhibitor (BL/BLI) antibiotics like cefaperazone/sulbactam was seen in 60% of Pseudomonas isolates. Sensitivity to colistin was noted in 89% of Klebsiella and 82% of E. coli isolates. The incidence of methicillin resistant staphylococcus aureus (MRSA) was 50%. Conclusion: The knowledge of the microbiological profile and resistance patterns among patients treated for paediatric cancer with febrile neutropenia is a key factor in deciding the antimicrobial policy.

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Section: Discussionmentioning

confidence: 99%

Bloodstream Infections in Paediatric Cancer Patients with Febrile Neutropenia in a Tertiary Cancer Centre in North-East India

Talukdar,

Barman,

Hazarika

et al. 2023

Asian Pac J Cancer Care

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“…Even though febrile neutropenia affects both adult and pediatric patients, children with febrile neutropenia have a higher risk than adults of infections of unknown origin [36]. Patients with a high-risk of presenting febrile neutropenia also present some of the following factors: (a) C-reactive protein (CRP) > 90 mg/L, (b) hypotension, (c) platelet count below 50,000 platelets/microliter, (d) relapsed leukemia, or (e) the elapsed time between the end of chemotherapy and the beginning of fever being less than 7 days [36,37].…”

Section: Febrile Neutropeniamentioning

confidence: 99%

Neutropenia in Pediatric Oncological Patients

Rosales,

Uribe Rosales,

de Jesús Ramos-Nieto

et al. 2024

New Updates in Tumor Microenvironment [Working Title]

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In 2020, more than 275,000 children and adolescents from 0 to 19 years of age were diagnosed with cancer in the world. Acute myeloid leukemia or acute lymphoblastic leukemia are the most frequent types of cancer. Leukemia is a serious condition that is fatal in many cases. Since tumor cells are present in both, bone marrow and circulating blood, very aggressive therapeutic treatments are required to eliminate tumor cells. Neutrophils are white blood cells that first respond against microbial pathogens and are produced in the bone marrow. Several drugs used in leukemia cancer treatment can reduce the total neutrophil number causing neutropenia. In this chapter we will briefly describe neutrophil maturation and functions as well as the different types of neutropenia. We will also focus on neutropenia consequences and some clinical approaches for treating neutropenia in pediatric patients.

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“…Myelosuppression often occurs in lymphoma patients who are treated with chemotherapy. During the myelosuppression stage, especially in the case of granulocytosis, patients have lower immunity and are prone to infection (2)(3)(4). Infection not only increases medical costs but also causes chemotherapy dose reductions, dose delays, or even treatment discontinuation that may result in prolonged hospitalization and reduced overall survival.…”

Section: Introductionmentioning

confidence: 99%

IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma

Zhu

Li²,

Zheng³

et al. 2022

Front. Immunol.

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To investigate the Th1/Th2 cytokine profile in patients with lymphoma during the myelosuppression stage of infection. 52 patients with gram-negative bacterial infection (G- group), 49 patients with gram-positive bacterial infection (G+ group), 51 uninfected patients with lymphoma (uninfected group) and 20 healthy controls (healthy group) were enrolled in this study. We evaluated the quantification of Th1/Th2 cytokines with flow cytometry bead assay (CBA) in the sera to explore a rapid diagnostic method to determine the type of infection and anti-infective effect. The levels of procalcitonin (PCT) were also detected simultaneously. The four groups did not differ with regard to IL-2 and IL-4 (P>0.05). The IFN-γ and TNF-α levels of patients with lymphoma were higher than those of healthy controls (P<0.05). There was significantly upregulated IL-6 and IL-10 expression in the G- group (P<0.001). A similar trend was reflected in the IL-6 of the G+ group, which was significantly increased (P<0.001). However, no significant upregulation was observed for IL-10 in the G+ group. According to the different degrees of increased IL-6 and IL-10 levels, We proposed to use the G- Bacterial Infection Cytokine Profile (G- BICP) and the G+ Bacterial Infection Cytokine Profile (G+ BICP) for the first time to differentiate between Gram-negative and Gram-positive (G-/G+) bacterial infection in adults with lymphoma in the myelosuppression stage after chemotherapy. The IL-6, IL-10 and PCT in the G- group and the IL-6, PCT in the G+ group were significantly decreased at day 4 and day 8 compared with those at day 1. IL-6 and IL-10 are closely associated with the severity and treatment efficacy in adults with lymphomas who develop infections after chemotherapy and can help distinguish between G- and G+ bacterial infections at an early stage.

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Bloodstream infection in pediatric patients with febrile neutropenia induced by chemotherapy

Cited by 6 publications

References 25 publications

Bloodstream Infections in Paediatric Cancer Patients with Febrile Neutropenia in a Tertiary Cancer Centre in North-East India

Bloodstream Infections in Paediatric Cancer Patients with Febrile Neutropenia in a Tertiary Cancer Centre in North-East India

Neutropenia in Pediatric Oncological Patients

IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma

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