Bloodstream infection in heart transplant recipients: 12-year experience at a university hospital in Taiwan

Abstract

There was a high incidence of BSI after heart transplantation in Taiwan, especially infections caused by Enterobacter species and A. baumannii. Mortality was high in patients with infection caused by Pseudomonas, Candida, and Cryptococcus and in patients with severe sepsis.

Burden and consequences of retained cardiovascular implantable electronic device lead fragments after heart transplantation

“…2 Specifically, bloodstream infections are not infrequent in this population treated with immunosuppression, and are associated with a poor prognosis. 10,11 Infection requiring extraction of CIED fragments in transplant patients has been reported rarely in the literature. 12 There was a numerical higher percent of bloodstream infections in patients with a retained fragment, although this was not statistically significant.…”

Outcomes and Predictors of Early Infection after Heart Transplantation

“…According to the Scientific Registry of Transplant Recipients (SRTR) and Organ Procurement and Transplantation Network (OPTN) Annual Data Report in 2015, infection was the most common cause of death (2.3% of the series) at one year after OHT [2]. Infection within the first month post-OHT has demonstrated even higher mortality rates (13%-60%) in some studies [4,5]. Bacterial infections continue to be the most common type of severe infections [4,[6][7][8][9], with gram-positive organisms being the primary infecting pathogens [6].…”

“…Although the incidence and type of infection post-OHT have been reported [1,2,4,5], the characteristics of patients who develop infection in the early transplant period have not been described well. Descriptions of the organisms cultured, sites of infection, and risk factors contributing to these early infections are lacking.…”

Frequency and clinical outcomes of ESKAPE bacteremia in solid organ transplantation and the risk factors for mortality

“…Both morbidity rates and mortality rates of bacteremia depend on the type of transplantation. The morbidity rates in subjects with bacteremia have been reported to range from 4.8–11% in kidney, 8–24% in heart, 8–25.7% in lung, 4.5–65% in solitary pancreas or simultaneous kidney–pancreas, 61–69% in intestinal, and 10–34% in liver transplant recipients, respectively . Bacteremia associated mortality ranges from 3–33% in heart, 10–52% in liver, 6–25% in lung, 6–44.4% in solitary pancreas or simultaneous kidney–pancreas, and 2.5–11% in kidney transplant recipients .…”