Bloodstream Cells Phenotypically Identical to Human Mesenchymal Bone Marrow Stem Cells Circulate in Large Amounts Under the Influence of Acute Large Skin Damage: New Evidence for Their Use in Regenerative Medicine

Mansilla, Eduardo; Marín, Gustavo Horacio; Drago, Hugo; Sturla, F.; Salas, Eduardo; Gardiner, C.; Bossi, Silvia; Lamonega, R.; Guzman, Anna; Nunez, Andrea C.; Gil, M.A.; Piccinelli, Giorgio; Ibar, Ricardo; Soratti, Carlos

doi:10.1016/j.transproceed.2006.02.053

Cited by 177 publications

(115 citation statements)

References 5 publications

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“…There are also several reports of the derivation of MSC from circulating fetal blood or umbilical cord (Ye et al, 1994;Campagnoli et al, 2000Campagnoli et al, , 2001Erices et al, 2000), and of the presence of MSC in the peripheral blood of other species (Huss et al, 2000;Wu et al, 2003). The two studies by Mansilla et al (2006) and Wang et al (2006) suggest that injury/trauma might evoke the release of MSC; thus systemic administration of MSC might enhance the presence of the circulating MSC, which may ultimately lead to an enhanced therapeutic response if the cells can be efficiently targeted to the damaged tissues.…”

Section: Do Msc Occur Naturally In the Blood?mentioning

confidence: 99%

“…Similarly, Zvaifler et al (2000) isolated fibroblast-like cells expressing CD105 from the peripheral blood of healthy volunteers that were capable of showing features of osteoblasts or adipocytes, after appropriate culture conditions. Moreover, both Mansilla et al (2006) and Wang et al (2006) have reported interesting results regarding the natural presence of MSC in samples of human peripheral blood. Mansilla et al (2006) found significantly higher numbers of MSC in blood samples taken from acute burn patients than in healthy controls and observed that the percentage of MSCs in the blood correlated with the severity of the burn, which the authors propose could be a mechanism in the regeneration process.…”

Section: Do Msc Occur Naturally In the Blood?mentioning

confidence: 99%

“…Moreover, both Mansilla et al (2006) and Wang et al (2006) have reported interesting results regarding the natural presence of MSC in samples of human peripheral blood. Mansilla et al (2006) found significantly higher numbers of MSC in blood samples taken from acute burn patients than in healthy controls and observed that the percentage of MSCs in the blood correlated with the severity of the burn, which the authors propose could be a mechanism in the regeneration process. Wang et al (2006), on the other hand, reported a reduction in the circulating pool of MSC in patients 1-week after MI and suggested that the MSC may have been recruited to the damaged myocardium.…”

Section: Do Msc Occur Naturally In the Blood?mentioning

confidence: 99%

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Recent advances into the understanding of mesenchymal stem cell trafficking

et al. 2007

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SummaryThe use of adult stem cells to regenerate damaged tissue circumvents the moral and technical issues associated with the use of those from an embryonic source. Mesenchymal stem cells (MSC) can be isolated from a variety of tissues, most commonly from the bone marrow, and, although they represent a very small percentage of these cells, are easily expandable. Recently, the use of MSC has provided clinical benefit to patients with osteogenesis imperfecta, graft-versushost disease and myocardial infarction. The cellular cues that enabled the MSC to be directed to the sites of tissue damage and the mechanisms by which MSC then exert their therapeutic effect are becoming clearer. This review discusses the relative therapeutic importance of the ability of MSC to differentiate into multiple cell lineages or stimulate resident or attracted cells via a paracrine mode of action. It also reviews recent findings that MSC home to damaged tissues in a similar, but somewhat distinct, manner to that of leucocytes via the utilisation of adhesion molecules, such as selectins and integrins, and chemokines and their receptors in a manner reminiscent of leucocytes trafficking from the blood stream to inflammatory sites.

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Section: Do Msc Occur Naturally In the Blood?mentioning

confidence: 99%

Section: Do Msc Occur Naturally In the Blood?mentioning

confidence: 99%

Section: Do Msc Occur Naturally In the Blood?mentioning

confidence: 99%

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Recent advances into the understanding of mesenchymal stem cell trafficking

et al. 2007

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“…Whether bone marrow (BM) MSCs circulate in humans has been the subject of debate (Hoogduijn et al, 2014;Mansilla et al, 2006;Wang et al, 2006). Despite this, recent studies conducted in animal models of injury have provided robust evidence that endogenous bone marrow-derived stromal cells can circulate and localise in injured tissue (Chen et al, 2010;Gao et al, 2014;Hong et al, 2009;Shu et al, 2013).…”

Section: Mechanisms Of Msc and Pericyte Recruitment To Sites Of Injurymentioning

confidence: 99%

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Wong

Rowley

Redpath

et al. 2015

Pharmacology & Therapeutics

148

110

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Regenerative medicine using mesenchymal stem cells for the purposes of tissue repair has garnered considerable public attention due to the potential of returning tissues and organs to a normal, healthy state after injury or damage has occurred. To achieve this, progenitor cells such as pericytes and bone marrow-derived mesenchymal stem cells can be delivered exogenously, mobilised and recruited from within the body or transplanted in the form organs and tissues grown in the laboratory from stem cells. In this review, we summarise the recent evidence supporting the use of endogenously mobilised stem cell populations to enhance tissue repair along with the use of mesenchymal stem cells and pericytes in the development of engineered tissues. Finally, we conclude with an overview of currently available therapeutic options to manipulate endogenous stem cells to promote tissue repair.

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“…40 compararam a presença de células com imunofenótipo de CTM no sangue periférico de indiví-duos normais e de grandes queimados com o objetivo de testar a hipótese de que, durante situações de grande lesão tecidual, o número destas células aumenta na circulação. Os autores encontraram CTM na circulação de ambos os grupos.…”

Section: Sangue Periférico Como Fonte De Células-tronco Mesenquimaisunclassified

Sangue periférico como fonte de células para terapia celular

Mendrone¹

2009

Rev. Bras. Hematol. Hemoter.

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Sangue periférico como fonte de células-tronco hematopoéticasAs células progenitoras hematopoéticas (CPH) da medula óssea são responsáveis pela formação de todas as célu-las maduras presentes no sangue. Embora recentemente tenham surgido evidências de que as CPH também têm a capacidade de se diferenciarem em outras linhagens celulares não hematopoéticas, a única aplicação clínica bem estabelecida para as CPH até o momento é a recomposição do tecido hematopoético medular após terapia mieloablativa no transplante de medula óssea.Desde o início dos anos 80, após descrições de que CPH também se encontram na circulação, o sangue periférico tem sido utilizado como fonte de CPH para a realização de transplante de medula óssea (TMO) autogênico e alogênico. Em 1981, Körbling 1 descreveu o que pode ter sido o primeiro caso de recuperação hematopoética em um paciente com leucemia mielóide crônica submetido a transplante autólogo de medula óssea, utilizando células mononucleares normais de sangue periférico. Estas células foram obtidas do sangue por leucaférese e criopreservadas para serem infundidas posteriormente, após regime de condicionamento. Em 1986, Kessinger 2 relatou pela primeira vez, em humanos, reconstituição hematopoética completa após transplante autólogo, utilizando células progenitoras mobilizadas de sangue perifé-rico. No mesmo ano, Reiffers 3 reportou um caso de leucemia aguda não linfocítica em primeira recaída tratada com transplante autólogo utilizando células progenitoras de sangue periférico coletadas previamente por leucaférese, e Körbling 4 publica um artigo relatando um caso de linfoma de Burkitt em remissão completa, também tratado com transplante autólogo utilizando células periféricas coletadas. Nos dois relatos, os pacientes apresentaram rápida reconstituição hematopoética.

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Bloodstream Cells Phenotypically Identical to Human Mesenchymal Bone Marrow Stem Cells Circulate in Large Amounts Under the Influence of Acute Large Skin Damage: New Evidence for Their Use in Regenerative Medicine

Cited by 177 publications

References 5 publications

Recent advances into the understanding of mesenchymal stem cell trafficking

Recent advances into the understanding of mesenchymal stem cell trafficking

Pericytes, mesenchymal stem cells and their contributions to tissue repair

Sangue periférico como fonte de células para terapia celular

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