Blood-Vessel-on-a-Chip Platforms for Evaluating Nanoparticle Drug Delivery Systems

Li, Yuancheng; Zhu, Kai; Liu, Xiao; Zhang, Yu Shrike

doi:10.2174/1389200218666170925114636

Cited by 17 publications

(12 citation statements)

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“…The combination of biomimetic cell/extracellular matrix (ECM) arrangements with microfluidic devices can be used reproduce not only the tissue microarchitecture but also the physicochemical cues under physiologically relevant conditions . As such, the organ‐on‐a‐chip systems are demonstrated to be superior to conventional planar, static cell culture strategies, providing improved accuracy in predicting human responses to pharmaceutical compounds, chemicals/toxins, and biological species …”

Section: Parameters and Constants Used For Modelingmentioning

confidence: 99%

A Foreign Body Response‐on‐a‐Chip Platform

Sharifi

Htwe

Righi

et al. 2019

Adv Healthcare Materials

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Understanding the foreign body response (FBR) and desiging strategies to modulate such a response represent a grand challenge for implant devices and biomaterials. Here, the development of a microfluidic platform is reported, i.e., the FBR-on-a-chip (FBROC) for modeling the cascade of events during immune cell response to implants. The platform models the native implant microenvironment where the implants are interfaced directly with surrounding tissues, as well as vasculature with circulating immune cells. The study demonstrates that the release of cytokines such as monocyte chemoattractant protein 1 (MCP-1) from the extracellular matrix (ECM)-like hydrogels in the bottom tissue chamber induces trans-endothelial migration of circulating monocytes in the vascular channel toward the hydrogels, thus mimicking implant-induced inflammation. Data using patient-derived peripheral blood mononuclear cells further reveal interpatient differences in FBR, highlighting the potential of this platform for monitoring FBR in a personalized manner. The prototype FBROC platform provides an enabling strategy to interrogate FBR on various implants, including biomaterials and engineered tissue constructs, in a physiologically relevant and individual-specific manner.

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Section: Parameters and Constants Used For Modelingmentioning

confidence: 99%

A Foreign Body Response‐on‐a‐Chip Platform

Sharifi

Htwe

Righi

et al. 2019

Adv Healthcare Materials

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“…Its fabrication consists of designing a microchannel network, which 645 allows for controlled loading, placement, diffusion, and permeation of microfluidic, a cell 646 chamber to replicate the microenvironment of the organ, and a cell-retention filter that can 647 also be used in connection sites with external tubing [242][243][244]. Despite the wide variety of 648 organ-on-a-chip platforms, such as liver [245][246][247][248][249][250], lung [251][252][253][254], vessel [255][256][257][258], and 649 kidney [259][260][261][262], which have been developed to improve studies on functional human 650 organs, only a few studies are aiming to create the ovary-on-a-chip. 651…”

Section: Microfluidics For Follicle Encapsulation 597mentioning

confidence: 99%

A Review on Biomaterials for Ovarian Tissue Engineering

et al. 2021

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Considerable challenges in engineering the female reproductive tissue are the follicle's 25 unique architecture, the need to recapitulate the extracellular matrix, and tissue 26 vascularization. Over the years, various strategies have been developed for preserving 27 fertility in women diagnosed with cancer, such as embryo, oocyte, or ovarian tissue 28 cryopreservation. While autotransplantation of cryopreserved ovarian tissue is a viable 29 choice to restore fertility in prepubertal girls and women who need to begin chemo-or 30 radiotherapy soon after the cancer diagnosis, it is not suitable for all patients due to the risk 31 of having malignant cells present in the ovarian fragments in some types of cancer. Advances 32 in tissue engineering such as 3D printing and ovary-on-a-chip technologies have the 33 potential to be a translational strategy for precisely recapitulating normal tissue in terms of 34 physical structure, vascularization, and molecular and cellular spatial distribution. This 35 review first introduces the ovarian tissue structure, describes suitable properties of 36 biomaterials for ovarian tissue engineering, and highlights recent advances in tissue 37 engineering for developing an artificial ovary. 38 39 40 Keywords 41 Ovarian tissue engineering; follicle; in vitro culture; 3D printing; ovary-on-a-chip 42 157 9 Ovarian cells can be added to the isolated follicles to support their development 158 during in vitro culture or transplantation. These cells secrete autocrine/paracrine 159 factors involved in folliculogenesis [44], and some of them will be recruited by 160 growing follicles to differentiate into theca cells [48]. Moreover, to improve follicle 161 survival, one could play with the biomaterial used as a scaffold, its porosity, 162 mechanical strength, and bioactive sites, as well as the addition of hormones, growth 163 factors, etc. [8, 11, 49-53]. For instance, to enhance vascularization, follicles could be 164 encapsulated in biomaterials with sustained release of vascular endothelial growth 165 factor (VEGF) [54] or basic fibroblast growth factor (bFGF) [55]. 166 167 4 Development of follicle culture systems 168The 2D in vitro system has been routinely used for follicle' in vitro culture [56][57][58][59][60][61]. Several 169 approaches, such as multi-well plates, cell culture dishes, or coverslips coated by gels or ECM 170 proteins such as collagen, fibronectin, and laminin, have been used in this procedure [3, 33, 171 62]. When isolated follicles are attached to a 2D culture surface, the somatic cells migrate to 172 the bottom of the well, gradually losing their interaction with the oocyte, and consequently, 173 the follicle 3D structure is destroyed [7]. Indeed, 2D culture systems are different from in 174 vivo microenvironment conditions, where cells and tissues have complex connections with 709This study was supported by grants from the Fonds National de la Recherche Scientifique de 710 Belgique (the Excellence of Science (FNRS-EOS), number 30443682 (PhD scholarship 711 award...

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“…Of particular interest are the mechanisms of PMmediated toxicity on the systemic health effects. In recent years, with the gradual advancement of multi-organ chips technology, it is expected to provide more clues to accelerate the clarification of the human toxicity of PM deposition, penetration and metabolism (Yuancheng et al, 2018;Carvalho et al, 2019), especially for the specific examples of lung-heart-on chip model, which could be used to investigate the systemic toxicology of PM into the human body.…”

Section: Heart-on-a-chipmentioning

confidence: 99%

Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter

Yang

Shen

Lin

et al. 2020

Front. Bioeng. Biotechnol.

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Recent developments in epidemiology have confirmed that airborne particulates are directly associated with respiratory pathology and mortality. Although clinical studies have yielded evidence of the effects of many types of fine particulates on human health, it still does not have a complete understanding of how physiological reactions are caused nor to the changes and damages associated with cellular and molecular mechanisms. Currently, most health assessment studies of particulate matter (PM) are conducted through cell culture or animal experiments. The results of such experiments often do not correlate with clinical findings or actual human reactions, and they also cause difficulty when investigating the causes of air pollution and associated human health hazards, the analysis of biomarkers, and the development of future pollution control strategies. Microfluidic-based cell culture technology has considerable potential to expand the capabilities of conventional cell culture by providing high-precision measurement, considerably increasing the potential for the parallelization of cellular assays, ensuring inexpensive automation, and improving the response of the overall cell culture in a more physiologically relevant context. This review paper focuses on integrating the important respiratory health problems caused by air pollution today, as well as the development and application of biomimetic organ-on-a-chip technology. This more precise experimental model is expected to accelerate studies elucidating the effect of PM on the human body and to reveal new opportunities for breakthroughs in disease research and drug development.

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Blood-Vessel-on-a-Chip Platforms for Evaluating Nanoparticle Drug Delivery Systems

Abstract: We anticipate that, further development of these blood-vessel-on-a-chip platforms with improved biomimetic parameters, tissue specificity, and personalization, will enable their wide applications in drug screening including nanomedicine.

Cited by 17 publications

References 0 publications

A Foreign Body Response‐on‐a‐Chip Platform

A Foreign Body Response‐on‐a‐Chip Platform

A Review on Biomaterials for Ovarian Tissue Engineering

Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter

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