Blood versus bone marrow pentobarbital concentrations

Winek, Charles L.; Costantino, Anthony; Wahba, Wagdy W.; Collom, Wellon D.

doi:10.1016/0379-0738(85)90100-8

Cited by 26 publications

(19 citation statements)

References 5 publications

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“…However, if the body remains are almost skeletonized and the soft tissues are highly putrefied, bone marrow can be used as a sample. Winek et al [1,2] and Iwasaki et al [3] reported that levels of some drugs in blood and bone marrow showed good correlation, indicating that bone marrow can be used to estimate the levels of some drugs and poisons in blood.…”

Section: Introductionmentioning

confidence: 95%

A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue

et al. 1991

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The distribution of diazepam in biological fluids and tissues of rats was examined 1, 2, 4 and 8 h after intraperitoneal administration by using a radioimmunoassay with specific anti-diazepam antibody. The diazepam levels in serum, saliva, brain and bone marrow decreased over a period of 2 h and levelled off 4 h after administration. The diazepam concentration in bone marrow was much higher than in serum, saliva and brain, suggesting an accumulation of diazepam in this tissue. This indicates that bone marrow could be a very useful material for the detection of diazepam in skeletonized remains. The diazepam concentrations in bone marrow, serum, saliva and brain showed a linear relationship (r = 0.860-0.997), indicating that a valid estimate of diazepam concentration in blood can be made from bone marrow samples.

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Section: Introductionmentioning

confidence: 95%

A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue

et al. 1991

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“…In human bone marrow antidepressants, antipsychotic drugs, benzodiazepines [6,7], opiates [7,8], ethchlorvynol [9], amphetamine, methamphetamine [10], methadone together with its metabolite EDDP [11], paracetamol and dextropropoxyphene www.elsevier.com/locate/forsciint Forensic Science International 156 (2006) 213-218 [12] have been detected. In animal (rabbit) bone marrow, ethanol [13], methanol [14], barbiturates [15], benzodiazepines [16], ethchlorvynol [17], isopropanol [18], methamphetamine and amphetamine [19] have been found.…”

Section: Introductionmentioning

confidence: 97%

Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death

Schloegl¹,

Rost²,

Schmidt³

et al. 2006

Forensic Science International

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“…Such correlations are more or less significant depending on the xenobiotic, as reported in Table 4. Winek et al demonstrated that extrapolation of blood level from BM level was possible in a rabbit model, for desipramine [24], flurazepam [22], isopropanol [18], methanol [23], nortriptyline [3] and pentobarbital [16].…”

Section: Correlation Between Bm and Blood Concentrationsmentioning

confidence: 99%

“…Conversely, the concentration of acetone decreased, probably due to its volatility. Pentobarbital underwent a slight increase between 6 and 12 h postmortem, inducing an increase in the BM/blood ratio and a decrease in the correlation between blood and BM levels [16].…”

Section: Postmortem Changes and Stability Of Xenobiotics In Bmmentioning

confidence: 99%

“…In forensic toxicology, the first report of BM analysis was in 1943, to document the kinetics of alcohol [14]. In the 1980s, Winek et al [3,[15][16][17][18][19][20][21][22][23][24] intensively studied the correlation between blood and BM in both animal and human models. During the following decade, few toxicological data on BM were published, except for some case reports.…”

Section: Introductionmentioning

confidence: 99%

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State-of-the-art of bone marrow analysis in forensic toxicology: a review

et al. 2010

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Although blood is the reference medium in the field of forensic toxicology, alternative matrices are required in case of limited, unavailable or unusable blood samples. The present review investigated the suitability of bone marrow (BM) as an alternative matrix to characterize xenobiotic consumption and its influence on the occurrence of death. Basic data on BM physiology are reported in order to highlight the specificities of this matrix and their analytical and toxicokinetic consequences. A review of case reports, animal and human studies involving BM sample analysis focuses on the various parameters of interpretation of toxicological results: analytic limits, sampling location, pharmacokinetics, blood/BM concentration correlation, stability and postmortem redistribution. Tables summarizing the analytical conditions and quantification of 45 compounds from BM samples provide a useful tool for toxicologists. A specific section devoted to ethanol shows that, despite successful quantification, interpretation is highly dependent on postmortem interval. In conclusion, BM is an interesting alternative matrix, and further experimental data and validated assays are required to confirm its great potential relevance in forensic toxicology.

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Blood versus bone marrow pentobarbital concentrations

Cited by 26 publications

References 5 publications

A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue

A comparative study of diazepam levels in bone marrow versus serum, saliva and brain tissue

Distribution of ethyl glucuronide in rib bone marrow, other tissues and body liquids as proof of alcohol consumption before death

State-of-the-art of bone marrow analysis in forensic toxicology: a review

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