Blood Trauma in Plastic Haemodialysis Cannulae

Abstract

To investigate the haemolysis in haemodialysis cannulae, an in-vitro set up is built, using a unipuncture dialysis system. This system is connected to a bag with fresh calf's blood, by the cannula under test, mounted in a large bloodline (5mm diameter). The blood characteristics are kept constant by means of a bicarbonate dialysate in the dialyser. During a 6h period, haematological parameters are regularly sampled. Flow through the cannulae is recorded, which is about 500mUmin. Four different cannulae are tested and compared to the results obtained without any cannula in the circuit. In all cases a linear increase in plasma free haemoglobin levels is found after 6h. The cannulae can be ranked from 8F catheter over 13G, 14G to 16G cannula, the latter producing the highest degree of haemolysis. When using plastic cannulae at high blood flows, their haemolytic effect may not be neglected.

Significance of hemolysis on extracorporeal life support after cardiac surgery in children

“…In our system, the caliber of the hemofilter circuit to where part of the ECLS blood was diverted was 50% of the caliber of the remainder of the ECLS circuit. De Wachter et al [26] demonstrated, in vitro, that FHb levels varied inversely with the sizes of the cannulae connecting to a blood line with a large bore. On the other hand, Luckraz et al [27] observed enhanced hemolysis when CRRT was initiated through a separate vascular access in patients requiring ventricular assist device support.…”

Investigation on Mechanical and Bio-Mechanical Performance of a Centrifugal Blood Pump

“…In order to validate the aforementioned equations, and prior to implement the above method for the MIH [19] and Wachter et al [20]. Schematic of the cannulae is shown in Fig.…”

Numerical Study of Turbulence Models in the Computation of Blood Flow in Cannulas

“…De Wachter et al [12] used calf blood in their investigations. For comparative purposes, the same fluid was studied within this work.…”

“…De Wachter et al studied empirically [12] and numerically [7] the hemolysis in cannulas during a dialysis procedure. Figure 1 describes the geometry used in the numerical study.…”