Blood refractive index modelling in the visible and near infrared spectral regions

Abstract

We present the calculation of blood refractive index based on the experimental data for the real part of the refractive index of the main protein components, haemoglobin and albumin. The refractive index of blood proteins was measured using the multi-wavelength Abbe refractometer at the wavelengths 480

Health monitoring scheme‐based Forster resonance energy transfer nanocommunications in the Internet of Biological Nanothings

“…The numerical analysis is performed by using MATLAB. The simulation parameters are recorded in Table 2 and using the data set of refractive index of blood medium from Lazareva and Tuchin 31 . We associated with every plot the default parameters inside the figure.…”

Measurement of tissue optical properties in the context of tissue optical clearing

“…The possibility of implementation of the refractometric method for revealing critical temperatures corresponding to phase transitions in tissues and cell structures was also demonstrated on the examples of human and porcine ATs. The obtained data for RI and its temperature increments for AT, Table 6 RI of human hemoglobin (260 g∕l) and albumin (55 g∕l) solutions, specific increment (α), and temperature increment (dn∕dT ) 112,113,116 Wavelength (nm) Hemoglobin Albumin human hemoglobin, and albumin are the new data supplementary to the data available in the literature. 17,87,103,123 It is important to note that in addition to classical refractometry, the spatially resolved phase imaging methods allowing for quantitative determination of RI distribution in tissues and cells are rapidly developing.…”

“…The fascicles were mounted in a slightly stretched state on an object-plate using binder clips and covered with a cover slip. Table 7 Coefficients of Sellmeier dispersion equation for human hemoglobin (260 g∕l) and albumin (55 g∕l) solutions 112,113,116 Solution In the measurements, an OCT-system ThorLabs-OCP930SR with a center wavelength (λ c ) of 930 nm was used. To estimate the average group RI n g of the tissue using OCT, a common method was employed, 93,[143][144][145] in which the group RI and physical thickness of the sample are determined from the measured values of the optical path length and shift of the image of a reflecting surface arranged beyond the sample with respect to its position in the absence of the sample [in our experimental geometry, as in Ref.…”

“…110 The refractometric properties of biological tissues and their individual components, such as human, porcine, and rat AT, porcine muscle tissue, rat brain tissue, and the main blood proteins-hemoglobin and albumin, have been studied in a wide range of wavelengths and temperatures. [111][112][113][114][115][116][117][118] The temperature dependences of RIs were analyzed for the presence of critical points corresponding to phase transitions. Figure 4 shows temperature dependence for the mean RI for abdominal human AT measured using multiwavelength Abbe refractometer DR-M2/1550 (Atago, Japan) at 930 nm and Table 1 The approximations for wavelength dependence of reduced scattering coefficient in the spectral range from 400 to 1300 nm for selected tissues.…”

Compact system for in situ laser Doppler velocimetry of blood flow

“…Simulations at each targeted flowrate allowed to extract corresponding maximal velocity values at the center of the channel (see Table 2) where the flow is fully developed when the fiber is placed upstream. Corresponding theoretical Doppler frequencies were calculated according to the relation introduced in section 2.1 using the refractive index of whole blood n = 1,3456 reported in literature for λ = 1550 nm [18]. Computational fluid dynamics were used to investigate flow disturbance induced by the different fiber types positioned upstream or downstream in the channel.…”