2015
DOI: 10.1097/md.0000000000000896
|View full text |Cite
|
Sign up to set email alerts
|

Blood Pressure Reduction in the Acute Phase of an Ischemic Stroke Does Not Improve Short- or Long-Term Dependency or Mortality

Abstract: The purpose of this study was to perform a meta-analysis of current literature to determine whether lowering blood pressure (BP) during the acute phase of an ischemic stroke improves short- and long-term outcomes.PubMed, Cochrane, and Embase were searched until September 5, 2014 using combinations of the search terms: blood pressure reduction, reduced blood pressure, lowering blood pressure, ischemic stroke, acute stroke, and intra-cerebral hemorrhage. Inclusion criteria were randomized controlled trial and pa… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
13
0
6

Year Published

2017
2017
2020
2020

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 31 publications
(20 citation statements)
references
References 40 publications
1
13
0
6
Order By: Relevance
“…The neutral effect on functional outcome, i.e., death or dependency and mRS distribution, was also found in previous studies and meta-analyses [20,35,[41][42][43]. Death or disability after a stroke event has led to plenty of harm and placed burdens on stroke patients and their family members, and this was the most important prognosis [50].…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…The neutral effect on functional outcome, i.e., death or dependency and mRS distribution, was also found in previous studies and meta-analyses [20,35,[41][42][43]. Death or disability after a stroke event has led to plenty of harm and placed burdens on stroke patients and their family members, and this was the most important prognosis [50].…”
Section: Discussionsupporting
confidence: 60%
“…The period of reported outcomes varied from 7 days to 1 year for most studies in this eld, so data in the short term (7-30 days) and long term (3 months or longer), along with their combination at the follow-up endpoint, were analyzed. The short-term and longterm de nition here was modi ed from reported studies in this eld [25,35,[40][41][42][43]. For additional details on functional outcome, the distribution of mRS scores was assessed.…”
Section: Data Extraction and Statistical Analysismentioning
confidence: 99%
“…Whether or not high BP is associated with poor outcome after acute ischaemic stroke has been extensively debated with conflicting results. Recently, three meta-analyses have neither supported nor opposed early BP lowering in acute ischaemic stroke with respect to the effect on short or long term morbidity and mortality 19,20,21 . It may instead be BP variability 22,23 and extremes of BP 24,25 that have an influence on poorer outcomes in the acute post-stroke phase.…”
Section: Discussionmentioning
confidence: 99%
“…50 Trials of antihypertensive therapy at the time of an acute stroke have not shown significant effects on short or long-term outcomes. 51,52 Nonetheless, there remains concern that rapid lowering of blood pressure immediately following stroke in a patient with symptomatic carotid disease might increase infarct volume and worsen neurological deficit. For asymptomatic patients, the AHA strongly recommends maintaining blood pressure below 140/90 mm Hg.…”
Section: Medical Managementmentioning
confidence: 99%