Blood pressure changes in young male subjects exposed to a median altitude

Sızlan, Ali; Ogur, Recai; Özer, Mustafa; Irmak, M. Kemal

doi:10.1007/s10286-008-0459-y

Cited by 24 publications

(27 citation statements)

References 42 publications

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“…Studies of the effects of climate, altitude, and BP are marked by the variability of individual responses and a multitude of interacting variables. In addition to factors that affect BP independently of altitude, such as sodium intake, diet, exercise, body mass index (BMI), and age, increased altitude introduces the additional factors of hypoxia, cold, wind, altitude sickness, dehydration, and stress associated with an environmental change 1 . Interrelationships between these variables include the positive association between cold climate and increased BMI 2 .…”

Section: Discussionmentioning

confidence: 99%

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Altitude‐Related Hypertension

Handler

2009

J of Clinical Hypertension

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Section: Discussionmentioning

confidence: 99%

“…Mitigating some of these forces are human microenvironments that have been created to shield against some stressors. Individuals can be protected from temperature reductions of about 1°C for each 150 meters of elevation 1 with warm clothing and heated dwellings, but reduction of barometric pressure with altitude is unprotected.…”

Section: Discussionmentioning

confidence: 99%

Altitude‐Related Hypertension

Handler

2009

J of Clinical Hypertension

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“…In patients with (borderline or overt) hypertension and normal subjects, increased plasma levels of epinephrine and norepinephrine following ascent to high altitude are associated with a rise in MAP (Somers et al, 1988;Palatini et al, 1989;Reeves et al, 1992;Wolfel et al, 1994;Calbet, 2003;Kara et al, 2003;Wu et al, 2007;Sizlan et al, 2008). During prolonged exposure to high altitude (months), in most (healthy) subjects, the increase in MAP subsides partially, but may not return completely to low-altitude values (Wu et al, 2007;Sizlan et al, 2008).…”

Section: Systemic Blood Pressurementioning

confidence: 93%

Nervous System Function during Exercise in Hypoxia

Amann

Kayser

2009

High Altitude Medicine & Biology

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Aerobic exercise capacity decreases with exposure to hypoxia. This article focuses on the effects of hypoxia on nervous system function and the potential consequences for the exercising human. Emphasis is put on somatosensory muscle afferents due to their crucial role in the reflex inhibition of muscle activation and in cardiorespiratory reflex control during exercise. We review the evidence of hypoxia influences on muscle afferents and discuss important consequences for exercise performance. Efferent (motor) nerves are less affected at altitude and are thought to stay fairly functional even in severe levels of arterial hypoxemia. Altitude also alters autonomic nervous system functions, which are thought to play an important role in the regulation of cardiac output and ventilation. Finally, the consequences of hypoxia-induced cortical adaptations and dysfunctions are evaluated in terms of neurotransmitter turnover, brain electrical activity, and cortical excitability. Even though the cessation of exercise or the reduction of exercise intensity, when reaching maximum performance, implies reduced motor recruitment by the nervous system, the mechanisms that lead to the de-recruitment of active muscle are still not well understood. In moderate hypoxia, muscle afferents appear to play an important role, whereas in severe hypoxia brain oxygenation may play a more important role.

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“…Nevertheless, in some studies, elevated systemic pressure after ascent to high altitude has been reported to be sustained for months [56]. The abovementioned studies examined BP changes at rest.…”

Section: Hypertension At High Altitudementioning

confidence: 95%

Hypertension at High Altitude

Sarybaev

Mulajkar

Sikri

et al. 2014

Translational Research in Environmental and Occupational Stress

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Systemic hypoxia is associated with conditions like anemia, lung diseases, sleep disorders, breathing, and exposure to high altitude. The physiological responses including blood pressure regulation to acute, chronic, intermittent normobaric, and hypobaric hypoxia have been under intense investigation for the past many years; however, the regulatory mechanisms are incompletely understood. The available literature indicates a differential response to hypoxia in pulmonary versus systemic circulation. Multiple physiological and metabolic changes contribute towards high-altitude acclimatization; yet, in some individuals, exposure to high altitude could be life threatening due to maladaptation. There are a few studies on the prevalence of hypertension in high-altitude natives and sea-level dwellers exposed to high altitude (acute and chronic). Elevated blood pressure is an established risk factor for different cardiovascular disease and the evidence suggests that the blood pressure rises to a modest extent in patients with mild to moderate hypertension upon acute ascent to high altitude (Luks et al., Congenit Heart Dis 5:220-232, 2010), but there is no clear evidence on increased risk of complications due to increased systemic blood pressures. This book chapter reviews available literature on systemic blood pressure responses to high altitude. A. Sarybaev (*)

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Blood pressure changes in young male subjects exposed to a median altitude

Cited by 24 publications

References 42 publications

Altitude‐Related Hypertension

Altitude‐Related Hypertension

Nervous System Function during Exercise in Hypoxia

Hypertension at High Altitude

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