Blood Pressure Behaviour and Control in Turner Syndrome

Virdis, R; Cantu, M. C.; Ghizzoni, Lucia; Ammenti, Anita; G, Nori; Volta, C.; Cravidi, C; Vanelli, Maurizio; Balestrazzi, P.; Bernasconi, Sergio; Giovannelli, G

doi:10.3109/10641968609046595

Cited by 19 publications

(16 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Small vessel renovascular disease has been proposed as a possible explanation, given the elevated renin activity which may be found before oestrogen therapy is instituted. Karyotype does not appear to influence the prevalence of hypertension, which may be underestimated without the use of age-related normal ranges [3, 62, 82]. Hypertension is exacerbated by ethinyl oestradiol but not by natural oestrogens or growth hormone [31, 83].…”

Section: Clinical Manifestations Of Turner Syndrome In Adultsmentioning

confidence: 99%

Adulthood in Women with Turner Syndrome

Ostberg

Conway²

2003

Horm Res Paediatr

View full text Add to dashboard Cite

Turner syndrome, resulting from a complete or partial absence of one X chromosome, is the most commonly occurring chromosomal abnormality in females. Patients have traditionally been carefully followed in paediatric practice during childhood, but were often discharged to primary care on reaching adulthood. Adults with Turner syndrome are thought to have a reduced life expectancy, mainly due to excess cardiovascular risk, but they may also have multiple comorbidities including hypothyroidism, deafness, osteoporosis and the attendant problems of oestrogen deficiency and infertility. A multidisciplinary approach to focused adult care is needed, with consideration of how to optimise surveillance strategies in these women.

show abstract

Section: Clinical Manifestations Of Turner Syndrome In Adultsmentioning

confidence: 99%

Adulthood in Women with Turner Syndrome

Ostberg

Conway²

2003

Horm Res Paediatr

View full text Add to dashboard Cite

show abstract

“…Its etiology is considered multifactorial, while possible mechanisms include high levels of plasma renin activity, obesity, aortic coarctation, and renal vascular abnormality [8,13,14]. In this report, the patient had untreated hypertension and associated cerebral hemorrhage, but her primary physician had not recognized hypertension during her routine visits.…”

Section: Discussionmentioning

confidence: 94%

Hypertensive Cerebral Hemorrhage in a Patient with Turner Syndrome Caused by Deletion in the Short Arm of the X Chromosome

Hori

Ohkura²,

Ebisudani

et al. 2017

Pediatr Neurosurg

View full text Add to dashboard Cite

Turner syndrome is a chromosomal disorder usually caused by complete deletion of an X chromosome, with deletion in the short arm of the X chromosome being a rare cause of the condition. Patients with Turner syndrome commonly develop hypertension, and associated vascular complications such as aortic dissection or cerebral hemorrhage have been reported. Cerebral hemorrhage in Turner syndrome is a rare complication, and only a few reports have been published. In these reports, all patients have XO karyotypes or a mosaic type as the cause of Turner syndrome, while no other Turner syndrome types have been documented. In this report, we present for the first time a patient with Turner syndrome caused by deletion in the short arm of the X chromosome who experienced hypertensive hemorrhage as a late complication.

show abstract

“…The contribution of the RAA axis in the pathogenesis of hypertension remains uncertain. In younger Turner syndrome girls, increased levels of plasma renin activity are found to be associated with hypertension and abnormal response to angiotensin-converting enzyme (ACE) inhibition in one study [34], but this relationship could not be confirmed in another [51]. The sympathetic nervous system -an important actor in blood pressure regulation [52] -is over-activated in Turner syndrome [35,53] and leads to both increased blood pressure and a higher heart rate.…”

Section: Cause Of Hypertension In Turner Syndromementioning

confidence: 94%

Arterial hypertension in Turner syndrome

Groote¹,

Demulier²,

Backer³

et al. 2015

Journal of Hypertension

View full text Add to dashboard Cite

Turner syndrome is a rare chromosomal disorder with complete or partial absence of one X chromosome that only occurs in women. Clinical presentation is variable, but congenital and acquired cardiovascular diseases are frequently associated diseases that add significantly to the increased morbidity and mortality in Turner syndrome patients. Arterial hypertension is reported in 13-58% of adult Turner syndrome patients and confers an increased risk for stroke and aortic dissection. Hypertension can be present from childhood on and is reported in one-quarter of the paediatric Turner syndrome patients. This article reviews the prevalence and cause of arterial hypertension in Turner syndrome and describes the relationship between blood pressure, aortic dilation and increased cardiovascular risk. We compare current treatment strategies and also propose an integrated practical approach for the diagnosis and treatment of hypertension in Turner syndrome applicable in daily practice.

show abstract

Blood Pressure Behaviour and Control in Turner Syndrome

Abstract: TS patients show high frequency of hypertension in pediatric age. Estrogen therapy is an outbreaking and worsening factor. An estrogen independent role of the renin-angiotensin-aldosterone system in the pathogenesis of TS hypertension is still uncertain.

Cited by 19 publications

References 4 publications

Adulthood in Women with Turner Syndrome

Adulthood in Women with Turner Syndrome

Hypertensive Cerebral Hemorrhage in a Patient with Turner Syndrome Caused by Deletion in the Short Arm of the X Chromosome

Arterial hypertension in Turner syndrome

Contact Info

Product

Resources

About