Blood Pressure and Lipid Lowering Effects of Nigella sativa Seeds and Honey Mixture

Mohamad, Sarina; Ibrahim, Nor Hayati; Yusof, HayatiMohd

doi:10.9790/1959-03518996

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Combination of BSO and honey showed better effect compared to single administration. Sarina Mohamad et al (22) reported that fat-soluble antioxidant contained in BSO combined with antioxidant available in honey increased antioxidant capacity 3-4 times higher than single administration. The variability of lipid-soluble antioxidant component in BSO and honey mixture may have directly modulated lipid profiles.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats

Siddiq

Ilmiawan

Handini

2020

MMJ

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Background: The chemotherapeutic use of cisplatin (CP) is restricted because of its hepatotoxicity induced by oxidative stress. Malondialdehyde (MDA) is a secondary product of lipid peroxidation as a biomarker of oxidative stress. Individual administration of black seed oil (BSO) or honey (H) demonstrated hepatoprotective effect in rats. Interaction of both substances when administrated as combination can be evaluated using combination index (CI) to quantitatively depict synergism (CI<1), additive (CI=1) and antagonism effect (CI>1). Objective: to know the combination effect of BSO and honey on rat liver tissue given CP exposure. Methods: This study used 30 rats were divided into 10 groups. Normal group (N); Negative control group (NC); P1-P4 groups were administerated BSO (1 and 2 mL/kg) and honey (3.7 and 7.4 mL/kg); P5-P8 groups were combination of BSO and H. P1-P8 groups were given BSO and honey orally for 21 days. On the 18th day, NC and P1-P8 groups were given CP 8 mg/kg intraperitoneally, while the N group was given NaCl 0.9% 1 mL/kg intraperitoneally. Result: Malondialdehyde (MDA) levels were found to be lower in P1-P8 groups compared to negative control group and P6 and P7 groups have levels equivalent to MDA levels of normal control group (p > 0.05). Conclusion: Combination of BSO and honey provides a protective effect on cisplatin-induced rat liver tissue damage indicated by reduced MDA levels, but all combination group showed antagonism effect.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats

Siddiq

Ilmiawan

Handini

2020

MMJ

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“…CI analysis showed that NSO1-H1, NSO1-H2, and NSO2-H1-administered groups exhibited strong synergism while NSO2-H2-administered group exhibited very strong synergism. Mohamad et al 28 demonstrated that Trolox Equivalent of the lipophilic antioxidant capacity of the mixture of NS seeds and honey was higher than either NS seeds or honey individually which indicated that the mixture of NS seeds and honey demonstrated the highest antioxidant capacity. These findings suggested that lipid-soluble antioxidants in whole seeds of NS have a synergistic effect when combined with antioxidants in honey, thus causing a higher antioxidant capacity for the mixture as compared to either NS seeds or honey individually.…”

Section: Groupsmentioning

confidence: 99%

Efek Protektif Sinergis Kombinasi Minyak Jintan Hitam (Nigella sativa) Komersial dan Madu terhadap Nefrotoksisitas pada Tikus akibat Cisplatin

Noviana¹,

Ilmiawan²,

Handini³

2020

jbmi

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Abstrak Cisplatin (CP) merupakan agen kemoterapi yang banyak digunakan dan menyebabkan nefrotoksisitas. Minyak jintan hitam (MJH) dan madu (M) diketahui memiliki efek nefroprotektif. Tujuan: Mengetahui efek dan sinergitas kombinasi MJH dan madu pada kadar malondialdehid (MDA) ginjal tikus yang diberi pajanan CP. Metode: Penelitian ini menggunakan 30 ekor tikus jantan yang dibagi menjadi 10 kelompok: Kontrol Normal (KN) (diet ad libitum), MJH1 (1 mL/kgBB MJH), MJH2 (2 mL/kgBB MJH), M1 (3,7 mL/kgBB M), M2 (7,4 mL/kgBB M), MJH1-M1 (1 mL/kgBB MJH dan 3,7 mL/kgBB M), MJH1-M2 (1 mL/kgBB MJH dan 7,4 mL/kgBB M), MJH2-M1 (2 mL/kgBB MJH dan 3,7 mL/kgBB M), MJH2-M2 (2 mL/kgBB MJH dan 7,4 mL/kgBB M), dan CP (diet ad libitum). MJH dan madu diberikan secara oral selama 21 hari. Pada hari ke-18, KN diberikan NaCl 0,9% 1 ml/kgBB sedangkan sisanya diberikan CP dosis tunggal 8 mg/kgBB secara intraperitoneal. Kadar MDA ginjal diukur menggunakan metode thiobarbituric acid reactive substances (TBARS). Didapatkan kadar MDA ginjal yang lebih rendah pada semua kelompok dosis tunggal dan kombinasi dibandingkan dengan kelompok CP (p=0,000). Semua kelompok dosis kombinasi memiliki indeks kombinasi <1. Kombinasi MJH dan madu memberikan efek protektif sinergis terhadap kerusakan oksidatif jaringan ginjal tikus akibat pajanan CP. Kata kunci: Minyak jintan hitam, madu, indeks kombinasi, cisplatin, nefrotoksisitas Abstract Cisplatin (CP) is a widely used chemotherapeutic agent that induces nephrotoxicity. Nigella sativa oil (NSO) and honey (H) have demonsrated nephroprotective effect. To investigate the effect and synergy of NSO and honey combination on kidney malondialdehyde (MDA) levels in CP-induced rats. Thirty male rats were divided into ten groups: Normal Control (NC), NSO1, NSO2, H1, H2, NSO1-H1, NSO1-H2, NSO2-H1, NSO2-H2, and CP-treated group which received ad libitum diet, 1 mL/kgbwt. NSO, 2 mL/ kgbwt. NSO, 3.7 mL/kgbwt. H, 7.4 mL/kgbwt. H, 1 mL/kgbwt. NSO and 3.7 mL/kgbwt. H, 1 mL/kgbwt. NSO and 7.4 mL/kgbwt. H, 2 mL/kgbwt. NSO and 3.7 mL/kgbwt. H, 2 mL/kgbwt. NSO and 7.4 mL/kgbwt. H, ad libitum diet, respectively, for 21 days. On the 18th day, NC group received 1 ml/kgbwt. NaCl 0.9% while the rest received 8 mg/kgbwt. single dose CP intraperitoneally. Kidney MDA levels was measured using thiobarbituric acid reactive substance (TBARS) method. Kidney MDA levels was significantly lower in all single and combination dose treatment groups compared to CP-treated group (p=0,000). Combination index of all combination dose treatment groups is <1. NSO and honey combination provided synergistic protective effect against CP-induced oxidative damage in kidney tissue in rats. Keywords: Nigella sativa oil, honey, combination index, cisplatin, nephrotoxicity

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Health Promoting Activities of Nigella sativa Seeds

Aydin

Kart

2020

Black Cumin (Nigella Sativa) Seeds: Chemistry, Technology, Functionality, and Applications

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Blood Pressure and Lipid Lowering Effects of Nigella sativa Seeds and Honey Mixture

Abstract: The aim of this study was to investigate the effect(s) of a mixture ofNigella sativaseeds (N. sativa; black cumin or fennel) and honey on (i) the modulation of cardiovascular disease (CVD) risks among hypercholesterolemic and healthy subjects; and (ii)

Cited by 4 publications

References 27 publications

Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats

Protective Effect of Combination Commercial Black Seed Oil (Nigella sativa) and Honey Against Cisplatin-Induced Hepatotoxicity in Rats

Efek Protektif Sinergis Kombinasi Minyak Jintan Hitam (Nigella sativa) Komersial dan Madu terhadap Nefrotoksisitas pada Tikus akibat Cisplatin

Health Promoting Activities of Nigella sativa Seeds

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