“…Nevertheless, the mechanisms underlying the increased risk of cardiovascular disease among taxi drivers have not yet been fully investigated. An increase in blood pressure caused by long hours of driving together with various work-related stressors (4,7,(11)(12)(13)(14)(15), such as dealing with passengers, searching for potential customers along streets and roads, waiting at taxi stands for customers, traffic jams, rain, and highway driving, may contribute substantially to the increased cardiovascular risk. Some neurophysiological mechanisms (11,(15)(16)(17), including dysfunction of the autonomic nervous system, hyperreactivity of the cardiovascular system, and disturbed circadian rhythms of the endocrine system, may also occasionally result in fatal arrhythmia or chronically accelerated coronary Kobayashi et al atherosclerosis.…”