Blood pressure and heart rate in aripiprazole once – monthly and paliperidone 1 and 3-month long-acting preparations

Abstract

Objective: This study aims to evaluate the blood pressure and heart rates of the patients treated with aripiprazole once-monthly,
 paliperidone 1-month, and paliperidone 3-month long-acting injections.
 Patients and Methods: This study was a non-invasive observational study. Subjects using the same long-acting injection preparation
 for at least four months without skipped injections were assigned to 3 groups according to their treatments. They were screened
 starting from routine injection day and monthly for four months. Heart rate, systolic blood pressure, and diastolic blood pressure were
 recorded for each subject.
 Results: Systolic and diastolic blood pressure among the three treatment groups demonstrated no statıstıcal significance. The heart rate
 of the paliperidone 3-month group was significantly higher than the aripiprazole once-monthly group. However, the mean heart rate
 was within the physiological limits. Thus, a clinical significance can hardly be attributed.
 Conclusion: Aripiprazole once-monthly, paliperidone 1-month, and paliperidone 3- month long-acting injections are non-inferior
 regarding heart rate, systolic and diastolic blood pressure during the maintenance treatment.