Blood parameters changes in cord blood of newborns of hypertensive mothers

Abstract

The aim of this study was to investigate the changes in the peripheral blood of newborns of hypertensive mothers. The umbilical cord blood from newborns of 31 hypertensive mothers and 32 healthy mothers were examined. In all subjects, complete blood count, peripheral blood smear, reticulocyte count, vitamin B12, folate, ferritin levels and hemoglobin electrophoresis were performed. The subjects were followed up on for 1 year in terms of infections. RBC, hemoglobin, reticulocyte count and normoblast count were higher in the newborns of hypertensive mothers compared to the control group, and total leukocytes, neutrophil, lymphocyte, monocyte, eosinophil, and thrombocyte counts were lower. The number of neutropenic and thrombocytopenic subjects in newborns of hypertensive mothers was higher compared to the control group. On peripheral smears, dysplastic changes in neutrophils and erythrocytes were observed with a higher rate in newborns of hypertensive mothers compared to the control group. HbF levels were found to be higher in newborns of hypertensive mothers compared to the control group. During the follow-up period of 1 year, the number of infections in newborns of hypertensive mothers was found to be higher than the control group. Conclusion: Newborns of hypertensive mothers should be carefully evaluated and monitored in terms of hematologic abnormalities. Complete blood counts and peripheral blood smears can be used as significant parameters for early diagnosis of possible complications.

Study of Changes in Haemoglobin Level and Leukocyte Counts in Cord Blood of Newborns of Hypertensive Mothers in Agmc and Gb Pant Hospital

“…[3,5] But it contradicts the observation in another study where hemoglobin level was found to be lower in the newborns of hypertensive mothers. [4] In this study, leukopenia was found in 10% of subjects in study group.…”

“…A leukocyte count less than 5,000/mm 3 was considered leukopenic, a neutrophil count of less than 1,500/mm 3 was considered neutropenic and a lymphocyte count less than 3,000/mm 3 was considered lymphopenic. [3,8,13] Hematological parameters of study and control groups were shown in Table 2.…”

“…[3,10,12] Studies show multiple mechanisms leading to decrease in neutrophil count. [3,13] A number of pregnant mothers in the state of Tripura suffer from hypertension. In this study, cord blood was used to assess the Haemoglobin level (Hb) and leukocyte counts including Total Leukocyte Count (TLC) and Absolute Counts for different leukocytes of newborns of hypertensive mothers constituting the study group and compare it with that of newborns of normotensive mothers constituting the control group.…”

“…[3,4,10,11,12,7] This can be associated with infection and sepsis. [3,10,12] Studies show multiple mechanisms leading to decrease in neutrophil count. [3,13] A number of pregnant mothers in the state of Tripura suffer from hypertension.…”

Cord blood parameters change in pregnancy induced hypertension

“…24 In the study of Bolat A et al, total count of lymphocyte, eosinophil, monocyte, neutrophil was significantly lower in babies of pregnancy induced hypertension. 25 But in this study we documented only change in neutrophil count. It has been reported that risks of sepsis decrease in neutropenic infants by G-CSF administration.…”