Blood lipid peroxidation products and antioxidants in senile cataract

Garg, Renu; Verma, Manju; Mathur, Surekha; Murthy, P. S.

doi:10.1007/bf02896443

Cited by 12 publications

(16 citation statements)

References 18 publications

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“…Earlier studies have reported increased levels of the lipid peroxidation product, MDA, in the cataract subjects as compared to those in the controls, which was in accordance with our findings [5,[10][11][12][13]. The high levels of TBARS in the cataractous lenses may, in turn, be the result of the lipid peroxidation of the lens cell membrane, which is produced locally or they may be the consequence of the migration of the products from the retina [14][15][16].…”

Section: Resultssupporting

confidence: 93%

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Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

Katta

Katkam²,

Geetha³

2013

JCDR

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Background: Cataract is one of the major causes of a visual impairment, which eventually leads to blindness. An oxidative damage to the lens proteins is a major factor which leads to cataract formation. Therefore, we intended to study the relationship between the biochemical markers of oxidative stress and various forms of cataracts. Methods:We examined the lenses and the sera of 120 subjects who were aged 50 to 80 years, who were distributed in two groups, viz. the study group (90 patients) and the control group (30 subjects). The oxidative stress was assessed by estimating the lipid peroxidation product in the form of thiobarbituric acid reactive substances (TBARS), the antioxidant status by measuring the levels of vitamin E and the total antioxidant capacity (TAC). The study group patients were further divided into those with nuclear cataracts (30 patients), cortical cataracts (30 patients), and diabetic cataracts (30 patients).Results: In this study, it was found that the levels of TBARS in the study group were significantly high (p<0.001), whereas the TAC (p<0.001) and the vitamin E (p<0.001) levels were significantly low, both in the lenses and the blood of the study group as compared to those of the control group.

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Section: Resultssupporting

confidence: 93%

“…So, maybe, during the process of the free radical scavenge, vitamin E is used up and the level of vitamin E decreases in the lens [23]. But Pradhan AK et al, [18] and Garg et al, [10] did not find a much significant correlation between the serum or plasma levels of vitamin E and the age related cataracts.…”

Section: Resultsmentioning

confidence: 99%

Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

Katta

Katkam²,

Geetha³

2013

JCDR

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“…Low levels of vitamin E in diabetic cataract may be due to its utilization by counteracting ROS which increases the risk of cataract. 28 As the oxidative stress due to lipid peroxidation is increased there is concomitant decrease in vitamin E level and this is supported by …”

Section: Discussionmentioning

confidence: 93%

Role of oxidative stress in cataractogenesis

Bhatia¹,

Sontakke²,

Abhang

2017

Int J Res Med Sci

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Background: Cataract is a multifactorial disease and is a major cause of blindness in india. Oxidative stress is thought to be a major factor to initiate the process of cataractogenesis. It is today well established fact that oxidative stress participates in both age-related (senile) and diabetes-induced cataract (diabetic). Oxidative damage to the lens most likely arises as a consequence of an impaired antioxidant defence system, due to increased generation of ROS both by age and diabetes. The present study was designed to determine role of oxidative stress in cataractogensis and to compare levels of oxidative stress markers in senile and diabetic cataract patients.Methods: Serum malondialdehyde (MDA) and serum protein carbonyl (PC) were measured as indicator of oxidative stress whereas antioxidant status was assessed by estimating serum Total antioxidant capacity (TAC) and dietary antioxidants levels i.e vitamin C and vitamin E in senile and diabetic cataract patients compared with healthy controls.Results: The result reveal that the serum MDA and PC levels were significantly increased in patients with senile and diabetic cataract whereas serum TAC, vitamin C and Vitamin E were significantly reduced in senile and diabetic patients when compared with normal healthy controls.Conclusions: From the result, it is concluded that oxidative stress is in the foreground of cataract formation which includes senile and diabetic cataract. Oxidative stress produced in diabetic cataract patients is more as compared to senile cataract patients.

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“…Garg et.al. reported that the erythrocyte superoxide dismutase levels were significantly lower in advanced senile cataract than those in healthy controls (16). Yildirim et al Found the levels of malondialdehyde (MDA), glutathione (GSh), advanced oxidation protein products (AoPP) and superoxide dismutase (SoD) activities in the diabetic senile cataract group were significantly increased as compared to the nondiabetic senile cataract group (p<0.05) (45).…”

Section: Resultsmentioning

confidence: 99%