Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Aksoy, Şefika; Gürler, Bülent; Aksoy, Aziz; Özaslan, Mehmet

doi:10.2478/v10133-010-0020-8

Cited by 13 publications

(9 citation statements)

References 35 publications

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“…In case of diabetic patients increased glucose levels in the aqueous humor may induce glycation of lens proteins and subsequent generation of superoxide radicals . Higher levels of glycated protein and lipid peroxides were observed in diabetic cataractous lenses than in senile cataractous lenses . In the present study several molecules (methyltetrahydrofolic acid, taurine, niacinamide, xanthine, and uric acid) known from their antioxidant capabilities were found decreased (Table ) in AH of diabetics.…”

Section: Resultssupporting

confidence: 43%

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An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

et al. 2018

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Cataract is the leading cause of blindness worldwide. Epidemiological studies revealed up to a fivefold increased prevalence of cataracts in diabetic subjects. Metabolomics is nowadays frequently implemented to understand pathophysiological processes responsible for disease occurrence and progression. It has also been used recently to study the metabolic composition of aqueous humor (AH). AH is a transparent fluid which fills the anterior and posterior chambers of the eye. It supplies nutrients and removes metabolic waste from avascular tissues in the eye. The aim of this study was to use metabolomics to compare the AH of diabetic and non-diabetic patients undergoing cataract surgery. Several antioxidants (methyltetrahydrofolic acid, taurine, niacinamide, xanthine, and uric acid) were found decreased (-22 to -61%, p-value 0.05-0.003) in AH of diabetics. Also amino acids (AA) and derivatives were found decreased (-21 to -36%, p-value 0.05-0.01) while glycosylated AA increased (+75-98%, p-value 0.03-0.009) in this group of patients. Metformin was detected in AH of people taking this drug. To our knowledge, this is the first metabolomics study aiming to assess differences in AH composition between diabetic and non-diabetic patients with cataract. An increased oxidative stress and perturbations in amino acid metabolism in AH may be responsible for earlier cataract onset in diabetic patients.

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Section: Resultssupporting

confidence: 43%

“…Oxidative stress is thought to be one of the leading causes of cataract formation . It has been reported that blood levels of such lipid peroxidation products as hydroxyoctadecadienoic acid, malondialdehyde or 4‐hydroxynonenal were significantly higher in subjects with cataract compared to non‐cataract subjects .…”

Section: Resultsmentioning

confidence: 99%

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

et al. 2018

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“…However, TAC decreased in the spinal cord from saline-treated CCI rats at day 7. It has been demonstrated that TAC represents the enzymatic and non-enzymatic antioxidant compounds in the body such as superoxide dismutase, catalase, glutathione peroxidase and GSH ( 32 , 33 ). Some of these antioxidant parameters are reduced in neuropathic pain ( 6 , 22 , 31 ), while other, as catalase activity, increase after CCI ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain

Horst

Souza

Santos

et al. 2017

Braz J Med Biol Res

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N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Thus, our study assessed these parameters in the lumbosacral spinal cord of rats with chronic constriction injury (CCI) of the sciatic nerve, one of the most commonly employed animal models of neuropathic pain. Thirty-six male Wistar rats weighing 200–300 g were equally divided into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve). All rats received intraperitoneal injections of NAC (150 mg·kg−1·day−1) or saline for 1, 3, or 7 days. Rats were killed 1, 3, and 7 days after surgery. NAC treatment prevented the CCI-induced increase in lipid hydroperoxide levels only at day 1, although the amount was higher than that found in naive rats. NAC treatment also prevented the CCI-induced increase in ascorbic acid content, which occurred at days 1, 3, and 7. No significant change was found in TAC with NAC treatment. The changes observed here may be related to the antinociceptive effect of NAC because modulation of oxidative-stress parameters seemed to help normalize the spinal cord oxidative status altered by pain.

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“…The ratio of the total oxidants to the total antioxidants gives the OSI, the degree of oxidative stress. 25,26…”

Section: Experimental Details Measurement Of Total Antioxidant and Oxmentioning

confidence: 99%

A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS)

Chaturvedi¹,

Srivastava²,

Shukla³

et al. 2020

IJCMR

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Introduction: Irritable bowel syndrome (IBS), though a benign disorder is highly prevalent and imposes high cost and substantial morbidity upon general population. Long considered as functional disorder, IBS pathogenesis carries an organic basis at least in a subset of patients. Altered intestinal immune response and low grade intestinal inflammation have been confirmed as pathophysiology of IBS in few studies. Oxidative stress indicates that there is inflammation and, markers of oxidative stress may be developed as diagnostic tool for IBS in future. Study aimed to evaluate oxidative stress in form of total oxidant status (TOS), total anti-oxidant status (TAS), oxidative stress index (OSI) and serum prolidase activity (SPA) as a marker of intestinal inflammation in IBS patients and healthy controls. Material and methods: In this case -control study done at a teaching medical institute in north India over a period of one year, 120 IBS patients (cases) and 40 healthy volunteers (controls) were evaluated for TOS, TAS, OSI and SPA. Patients with IBS were sub-divided into 3 groups (40 each): diarrhea predominant, constipation predominant and mixed type (IBS-D, C and M respectively). Student t-test, chi-square test and ANOVA tests were used for statistical analysis. Results: Mean TOS, TOS/TAS (OSI) and prolidase levels were significantly higher in IBS group than control with p value of <0.001,< 0.001, and <0.01 respectively. Level of TOS was highest in IBS-D subgroup followed by IBS-M and Lowest in IBS-C subgroup showing a significant difference between IBS-D and IBS-C, IBS-D and IBS-M and IBS-M and IBS-C with p values <0.001 for each comparison. OSI was highest in IBS-D and lowest in IBS-C with significant differences between the subgroups (P<0.001). Only IBS-M subgroup had significantly higher serum prolidase activity when compared to controls (p<0.001) IBS-D (P=0.013) and IBS-C (P=0.01). TAS level was significantly higher in controls (P<0.001) than cases. There were significant differences between all four subgroups (p<0.001) except between IBS-C and IBS-M subgroups (P=0.294). Conclusion: This study observed that there is increased oxidative stress and decreased antioxidant capacity in patient with IBS. To support our results further prospective and randomized controlled trials are necessary.

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Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Cited by 13 publications

References 35 publications

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

An exploratory LC‐MS‐based metabolomics study reveals differences in aqueous humor composition between diabetic and non‐diabetic patients with cataract

Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain

A Study on the Role of Oxidative Stress and Prolidase Enzyme in the Clinical Evaluation of Irritable Bowel Syndrome (IBS)

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