Blood lead levels and childhood asthma

Mohammed, Ahmed A; Mohamed, Faisal Y; Elokda, E E; Ahmed, Adel Besheer

doi:10.1007/s13312-015-0628-8

Cited by 24 publications

(10 citation statements)

References 15 publications

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“…In agreement with these finding Mohammed et al 2015 found no difference between asthmatic patients and healthy controls in serum lead while serum lead > 10 mg/dl associated with increased severity of asthma and development of eosinophilia and elevated IgE (57) , however they found higher mean values (13.3 , 11.4 µgm/dl ) of lead among patients and controls compared with our study . Previous studies showed that higher blood lead has no relation with development of asthma (57,58) .while other studies (29, 51) showed that higher lead were found in asthmatic patients compared to controls. These last 2 studies despite apparent (61) found that the threshold of blood lead as a risk of asthma development varies among African Americans and Caucasians .…”

Section: Principle Of Test: Copper Forms With-(32dibromo-2-pyridyiazo)mentioning

confidence: 90%

Serum Lead, Copper and Zinc in Children With Bronchial Asthma

ELSAYED

Alkalyouby

Essa

2017

Zagazig University Medical Journal

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Background: Bronchial asthma is chronic inflammatory of the lung airways resulting in episodic airflow obstruction. Lead exposure results in alteration of immune system function resulting in asthma. Zinc, copper are component of antioxidant system and alteration of their level affect increase risk of asthma. Objective:. Determine the serum level of lead, zinc, copper in children with bronchial asthma and study their relation to development of asthma Patients and methods: The patient group included 38 full-term newborn infants diagnosed as having bronchial asthma who were selected from pediatric department Benha Teaching Hospital. The control group included 17 healthy child age and sex matched C-reactive protein (CRP) were measured by the ELISA technique (highly sensitive CRP). ESR was performed by the Wintrobe method, Serum lead was determined by atomic absorption method. Serum copper and zinc were determined by calorimetric method. Results: Serum copper and zinc were elevated in asthmatic children compared to controls with no relation to clinical manifestations or laboratory parameters .Serum lead showed no difference among patients and controls however it increased in severe cases compared moderate and mild cases and correlated positively with duration of admission. Conclusion:. : We determined serum copper, zinc and lead in children with bronchial asthma. We found elevated serum copper and zinc in asthmatic children compared to controls with no relation to clinical manifestations or laboratory parameters .Serum lead showed no difference among patients and controls, however it increased in severe cases compared moderate and mild cases and correlated positively with duration of admission. These results indicate importance of environmental exposure as a risk factor of asthma in children

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Section: Principle Of Test: Copper Forms With-(32dibromo-2-pyridyiazo)mentioning

confidence: 90%

Serum Lead, Copper and Zinc in Children With Bronchial Asthma

ELSAYED

Alkalyouby

Essa

2017

Zagazig University Medical Journal

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“…The need for lead testing for young children should be emphasized. Children with asthma with elevated blood lead levels > 10 mcg/dL have higher asthma severity compared to those with lower lead levels (Mohammed, Mohamed, El‐Okda, & Ahmed, 2015). The American Academy of Pediatrics (2016) recommends intervention for any blood level above 5 mcg/dL.…”

Section: Discussionmentioning

confidence: 99%

Preschool asthma: Examining environmental influences using geographic information systems

Quaranta

Swaine

Ryszka

2020

Public Health Nursing

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Objective This study was conducted to explore if environmental factors co‐occur in areas with high asthma rates in Head Start (HS) children. Design Descriptive. Sample Convenience sample of 56 children with asthma enrolled in HS, ages 3–5 years. Measurements Geographic Information Systems using ArcGIS 10.4 was used to geocode and map aggregated address data at the census tract level through vector map analysis. Location, race, economic status, pollution remediation sites, age of housing, and blood lead levels were assessed for areas with high asthma concentration. Results Most children with asthma resided in one census tract, which was 1% of the total service area. Fifty‐six percent of housing was built before 1960 with only 10% after 1990, suggesting deteriorating conditions. Pollution remediation sites were found in the vicinity of asthma cases. Elevated lead levels were found in 22% of all HS children; specific values for the children with asthma were not available. Conclusion Several co‐occurring factors were identified. The need for proactive interventions to decrease asthma risk/poor asthma outcomes with HS is evident. GIS locates children with high susceptibility to asthma. This allows public health nurses to target interventions and educate and empower families about environmental exposures and asthma risk factors.

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“…The study concluded that even though blood lead levels are not significantly associated with asthma diagnosis, the elevated blood levels of this metal lead to a more severe form of asthma in children, being related to eosinophilia and elevated immunoglobulin E levels. [ 9 ] The toxicity of blood lead levels on the nervous system is a major concern for children's normal development. According to the data of the Agency for Toxic Substances and Disease Registry (ATSDR), blood lead level in children is associated with encephalopathy.…”

Section: Discussionmentioning

confidence: 99%

Lead poisoning in a 16-year-old girl

Mărginean¹,

Meliţ²,

Moldovan

et al. 2016

Medicine

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Background:Lead is a toxic element of the environment which leads to major complications once it enters the blood stream, affecting multiple organs and systems of the body.Methods:We present the case of a 16-year-old girl, diagnosed with lead poisoning after occupational exposure due to the fact that the girl was actively involved in the family's pottery business.History revealed that the girl participated in the process of pottery, her father was also diagnosed with lead poisoning 2 years before. The patient's personal history underlined that approximately 1 year ago she presented with severe abdominal pain, being diagnosed with acute appendicitis and she underwent appendectomy, but the pain persisted, thus due to family history of lead poisoning, the suspicion of saturnine colic rose, and she was diagnosed with lead poisoning. The main symptoms and signs were severe abdominal pain, vomiting, and arterial hypertension. The clinical evolution was favorable under symptomatic treatment and chelation therapy.Results:Lead toxicity is a life-threatening condition because of its severe acute and chronic complications. In children, there is no safe blood lead level, prevention methods are, therefore, very important in order to avoid toxic multiorganic effects of this metal.Conclusion:Even though the diagnosis of lead poisoning remains difficult in children, it must also be taken into consideration by the clinician facing a child with gastrointestinal or neurological involvement.

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Blood lead levels and childhood asthma

Abstract: Blood lead levels are not significantly associated with diagnosis of asthma but elevated blood lead levels seem to be associated with increased asthma severity and higher frequency of eosinophilia and elevated immunoglobulin E levels.

Cited by 24 publications

References 15 publications

Serum Lead, Copper and Zinc in Children With Bronchial Asthma

Serum Lead, Copper and Zinc in Children With Bronchial Asthma

Preschool asthma: Examining environmental influences using geographic information systems

Lead poisoning in a 16-year-old girl

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