Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Wang, Ningjian; Chen, Chi; Nie, Xiaomin; Han, Bing; Li, Qin; Chen, Yi; Zhu, Chunfang; Xia, Fangzhen; Cang, Zhen; Lü, Meng; Meng, Ying; Zhai, Hualing; Lin, Donghui; Cui, Shiyong; Jensen, Michael D.; Lu, Yingli

doi:10.1038/srep18299

Cited by 68 publications

(47 citation statements)

References 43 publications

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“…The registration number is ChiCTR-ECS-14005052 (www.chictr.org.cn). Details about the study have been published previously111213. Briefly, from February to June 2014, 16 residential areas in Shanghai, Jiangxi Province and Zhejiang province were selected using a stratified and clustered method.…”

Section: Methodsmentioning

confidence: 99%

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

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We examined whether blood lead levels (BLLs) were associated with reproductive hormone levels in a cross-sectional study using data from the SPECT-China study. We selected 2286 men and 1571 postmenopausal women without hormone replacement therapy. BLLs, blood cadmium, total testosterone (TT), oestradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and sex hormone binding globulin(SHBG) levels were measured. The results showed that median values (interquartile range) of BLLs were 44.00 μg/L (29.00–62.30) for men and 41.00 μg/L (27.00–59.81) for postmenopausal women. In linear regression, after adjusting for age, current smoking status, body mass index, systolic blood pressure, diabetes and blood cadmium level, TT (P for trend = 0.001) and SHBG (P for trend < 0.001) levels were still positively associated with BLLs in men. Meanwhile, significant positive associations were found for BLLs with SHBG (P for trend = 0.002), FSH (P for trend = 0.001) and LH (P for trend = 0.026) levels in postmenopausal women. Additionally, the association between BLL and SHBG was modified by dysglycaemia (P for interaction = 0.03) in postmenopausal women. In conclusion, BLLs were associated with reproductive hormone levels in the general population of Chinese men and postmenopausal women, which may have important implications for human health. Concerted efforts to reduce adult lead exposure are warranted.

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Section: Methodsmentioning

confidence: 99%

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Chen

Wang

Zhai

et al. 2016

Sci Rep

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“…Environmental effects play important role in the development of metabolic disease. Our previous study has found potential relationships between blood lead and obesity in Chinese adults (Wang et al 2015a). Lead and cadmium have common routes via human bodies and sometimes have co-exposure effects on diseases Hambach et al 2013;Wang and Fowler 2008).…”

Section: Introductionmentioning

confidence: 98%

Blood cadmium in Chinese adults and its relationships with diabetes and obesity

Nie

Wang

Chen

et al. 2016

Environ Sci Pollut Res

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The aim of this study is to evaluate blood cadmium levels (BCLs) in Chinese adults and explore whether blood cadmium is associated with diabetes or obesity. This study included 5544 adults from a cross-sectional SPECT-China study. BCL and blood lead level (BLL) was measured by atomic absorption spectrometry. Fasting plasma glucose (FPG) was used to define prediabetes and diabetes. Overweight and obesity were defined by body mass index (BMI). The associations of BCL with prediabetes, diabetes, overweight, and obesity were analyzed by multinomial logistic regression analyses. Medians (interquartile range) of BCL were 1.97 μg/L (0.60-3.82) in men and 1.59 μg/L (0.54-3.51) in women. Subjects in low-economic-status areas and urban areas had significantly higher BCL. BCL in current smokers was significantly higher than in current non-smokers. In the adjusted model, a mild positive relationship between BCL and FPG was found. Meanwhile, the prevalence of prediabetes was increased according to the increase in BCL tertiles. Surprisingly, BCL had a negative relationship with prevalence of overweight. In conclusion, BCL in Chinese adults was much higher than in other developed countries and was influenced by gender, smoking, and residential area. BCL was positively related to prediabetes while negatively related to overweight.

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“…In USA, the combined prevalence of overweight and obesity had risen from 14.5% to 35.1% in adults [1], which is similar to growth seen in China from 14.6% to 32.3%, due to economic boom and lifestyle changes [2]. However, environmental factors are attributed to the rising prevalence of obesity, too.…”

Section: Introductionmentioning

confidence: 99%

“…Lead (Pb) is a kind of heavy metal widely used in gasoline and lead-acid battery industries [2]. Pb pollutants may be released as air pollution or waste mixtures into soil and waterways in the process of manufacturing, which were then up-taken through food, water and air [4].…”

Section: Introductionmentioning

confidence: 99%

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Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation

et al. 2017

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ObjectivePrevious studies have revealed the association of lead (Pb) exposure with obesity. DNA methylation alteration has been suggested to be one of the regulatory mechanisms of obesity. We aimed to explore whether Pb exposure is related with weight gain and DNA methylation alteration.MethodsMale adult 8 week Wistar rats were divided into 5 groups: the normal chow diet (NCD); the NCD+0.05%Pb; the NCD+0.15%Pb; the NCD+0.45%Pb and the high fat diet. Rats were exposed to different dosages of Pb through drinking water for 21 weeks. Body weight, fasted blood glucose level, fasted insulin level, homeostasis assessment of insulin resistance (HOMA-IR) index and lipid profile were detected. Intra-peritoneal glucose tolerance test (IPGTT) was constructed to evaluate the glucose tolerance. Lipid accumulation of liver was detected and liver DNA underwent whole genome bisulfite sequencing.ResultsThe NCD+0.05%Pb group had significantly greater weight, HOMA-IR and triglycerides, and lower glucose intolerance than the NCD group (P <0.05). This group also showed hepatic lipid accumulation. These metabolic changes were not observed in the other two Pb dosage groups. Furthermore, DNA hypermethylation extended along pathways related to glucose and lipid metabolism in NCD+0.05%Pb group.ConclusionPb exposure resulted in dose-specific weight gain in adult Wistar rats, accompanied by alteration of DNA methylation.

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Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study

Cited by 68 publications

References 43 publications

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Associations of blood lead levels with reproductive hormone levels in men and postmenopausal women: Results from the SPECT-China Study

Blood cadmium in Chinese adults and its relationships with diabetes and obesity

Lead Exposure Induces Weight Gain in Adult Rats, Accompanied by DNA Hypermethylation

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