Blood-Lead and Hypertension

Beevers, D. G.; Erskine, Eileen; Robertson, M P; Beattie, A. D.; Campbell, Brian C.; Goldberg, A.; Moore, Michael R.; Hawthorne, Victor M.

doi:10.1016/s0140-6736(76)92963-9

Cited by 155 publications

(46 citation statements)

References 19 publications

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“…Two studies reported only on young children (Ͻ10 years), 25,37 two studies were case reports, 45,48 one 66 recruited less than 50 persons, in one 54 owing to missing information the analysis was performed in less than 50 subjects, five estimated exposure from other measurements than the blood lead concentration, 30,77,78,81,88 and 11 did not provide enough information to compute the association size. 17,19,22,26,27,36,39,62,63,67,86 …”

Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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Studies on the possible association between blood pressure and blood lead have reached divergent conclusions. In a previous meta-analysis, a doubling of the blood lead concentration was associated with a 1.0/0.6 mm Hg increase in systolic and diastolic blood pressure (BP). This meta-analysis updates the analysis originally performed in 1994. Articles on the association between BP and blood lead were identified from computer searches from January 1980 to February 2001 using the Medical Literature Analysis and Retrieval System. Of the studies reviewed, 31 provided sufficient details to be considered. The meta-analysis included 58 518 subjects recruited from the general population in 19 surveys and from occupationally exposed groups in 12 studies. In all but four studies, the results were adjusted for age, and

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Section: Selection Of Studiesmentioning

confidence: 99%

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

et al. 2002

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“…Whether long-term lead exposure causes permanent hypertension is still being debated. In a study on workers' response to lead during a long period, Cramer & Dahlberg (3) did not find a raised prevalence of hypertension, while Beevers et al (2), in a case-referent study, observed a significant excess of cases with high blood lead levels among male hypertensives compared with normotensives.…”

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confidence: 99%

Blood pressure and other cardiovascular risk factors of long-term exposure to lead.

Kirkby¹,

Gyntelberg²

1985

Scand J Work Environ Health

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KIRKBY H, GYNTELBERG F, Bloodpressureand other cardiovascular risk factors of long-termexposure to lead. Scand J Work Environ Health II (1985) 15-19. The coronary risk profile was studied for 96 heavily exposed lead smelter workersemployed between 9 and 45 years and for a referencegroup not exposed to lead but comparable with respect to age, sex, height, weight, social grouping, occupational status, and alcohol and tobacco consumption.The lead smelterworkershad a little higher diastolic blood pressureand significantly more ischemic electrocardiographic changes, and their high-density lipoprotein levels were lower than the corresponding values of the referencegroup. The lead workers with electrocardiographic changes had higher blood pressures than the referents with correspondingchanges. These findings indicate a higher coronary risk profile for the examinedlead smelterworkers. The study supports the hypothesis of a positive association between lead exposure and arteriosclerosis and high blood pressure.

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“…Since 1881, the cardiovascular system has been a focus of investigations about the toxic effects of lead (3)(4)(5). With moderate to heavy exposures, there have been studies reporting cerebrovascular disease and nephritis resulting in increased mortality (6,7).…”

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confidence: 99%

The relationship of blood lead levels to blood pressure in the U.S. population.

Harlan

1988

Environ Health Perspect

107

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Numerous observations have indicated a relationship between moderate or heavy lead exposure and high blood pressure. To determine whether low-level lead exposure is related to blood pressure in the U.S. population, we analyzed data from the National Health and Nutrition Examination Survey II for persons 12 to 74 years of age. Significant correlations were found between blood lead and blood pressure for each race-gender group, and blood lead levels were significantly higher in groups with high diastolic blood pressure (> 90 mm Hg). Multiple stepwise regression models were developed to predict blood pressure. After adjusting for age, race, and body mass index, blood lead levels were significantly related to systolic and diastolic pressures in males but not in females. These findings and those from other studies confirm the relationship of blood lead and blood pressure at relatively low levels commonly observed in the general population. The strength and importance of this relationship require further study through epidemiologic and metabolic investigations.

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Blood-Lead and Hypertension

Cited by 155 publications

References 19 publications

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis

Blood pressure and other cardiovascular risk factors of long-term exposure to lead.

The relationship of blood lead levels to blood pressure in the U.S. population.

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