Blood lead and cadmium in age related macular degeneration in a Turkish urban population

Gungor, Elif Damar; Yülek, Fatma; Serkant, Utku; Toklu, Yasin; Hocaoğlu, Asım; Şimşek, Şaban

doi:10.1016/j.jtemb.2018.02.019

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…It is acknowledged that environmental and lifestyle factors affect the balance of bodily trace metals, and in particular, this occurs in the retina mainly through oxidative stress that originated from exposure of macular tissues to sunlight and local or systemic exposure to oxidative stressors, including smoke. In this line of research, important results have been gained mainly for cadmium (Cd) that, in most of these studies, has been found to be elevated in AMD patients, especially within the smoking population (Kim et al, 2016;Wu et al, 2014;Güngör et al, 2018). These findings are coherent with the results from histology studies, showing Cd accumulation in the retina and in the RPE, particularly in smokers (Wills et al, 2008).…”

Section: Essential Trace Metals: Diagnostic Perspectives In Ad and Amdmentioning

confidence: 66%

“…The proposed mechanisms of Cd uptake in the retina involve zinc transporters (ZIP4 and ZIP8) with high Cd affinity (Girijashanker et al, 2008). Studies on circulating intoxicant heavy metals have shown also increased levels of blood lead (Pb) (Güngör et al, 2018). Higher blood Pb and Cd levels in AMD (Güngör et al, 2018;Heesterbeek et al, 2020) together with increased levels of barium (Ba) have been found in neovascular AMD (236 patients with neovascular AMD compared with 236 age-matched controls).…”

Section: Essential Trace Metals: Diagnostic Perspectives In Ad and Amdmentioning

confidence: 99%

“…Studies on circulating intoxicant heavy metals have shown also increased levels of blood lead (Pb) (Güngör et al, 2018). Higher blood Pb and Cd levels in AMD (Güngör et al, 2018;Heesterbeek et al, 2020) together with increased levels of barium (Ba) have been found in neovascular AMD (236 patients with neovascular AMD compared with 236 age-matched controls). Conversely, chromium (Cr) concentration decreased.…”

Section: Essential Trace Metals: Diagnostic Perspectives In Ad and Amdmentioning

confidence: 99%

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Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration

et al. 2021

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Alzheimer’s disease (AD) is an age-associated neurodegenerative disease which is the most common cause of dementia among the elderly. Imbalance in nerve growth factor (NGF) signaling, metabolism, and/or defect in NGF transport to the basal forebrain cholinergic neurons occurs in patients affected with AD. According to the cholinergic hypothesis, an early and progressive synaptic and neuronal loss in a vulnerable population of basal forebrain involved in memory and learning processes leads to degeneration of cortical and hippocampal projections followed by cognitive impairment with accumulation of misfolded/aggregated Aβ and tau protein. The neuroprotective and regenerative effects of NGF on cholinergic neurons have been largely demonstrated, both in animal models of AD and in living patients. However, the development of this neurotrophin as a disease-modifying therapy in humans is challenged by both delivery limitations (inability to cross the blood–brain barrier (BBB), poor pharmacokinetic profile) and unwanted side effects (pain and weight loss). Age-related macular degeneration (AMD) is a retinal disease which represents the major cause of blindness in developed countries and shares several clinical and pathological features with AD, including alterations in NGF transduction pathways. Interestingly, nerve fiber layer thinning, degeneration of retinal ganglion cells and changes of vascular parameters, aggregation of Aβ and tau protein, and apoptosis also occur in the retina of both AD and AMD. A protective effect of ocular administration of NGF on both photoreceptor and retinal ganglion cell degeneration has been recently described. Besides, the current knowledge about the detection of essential trace metals associated with AD and AMD and their changes depending on the severity of diseases, either systemic or locally detected, further pave the way for a promising diagnostic approach. This review is aimed at describing the employment of NGF as a common therapeutic approach to AMD and AD and the diagnostic power of detection of essential trace metals associated with both diseases. The multiple approaches employed to allow a sustained release/targeting of NGF to the brain and its neurosensorial ocular extensions will be also discussed, highlighting innovative technologies and future translational prospects.

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Section: Essential Trace Metals: Diagnostic Perspectives In Ad and Amdmentioning

confidence: 66%

Section: Essential Trace Metals: Diagnostic Perspectives In Ad and Amdmentioning

confidence: 99%

Section: Essential Trace Metals: Diagnostic Perspectives In Ad and Amdmentioning

confidence: 99%

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Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration

et al. 2021

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Maternal exposure to cadmium from puberty through lactation induces abnormal reproductive development in female offspring

Wang²,

Li³

et al. 2022

Ecotoxicology and Environmental Safety

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Elemental concentrations in Choroid-RPE and retina of human eyes with age-related macular degeneration

Aberami

Nikhalashree

Bharathselvi

et al. 2019

Experimental Eye Research

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Blood lead and cadmium in age related macular degeneration in a Turkish urban population

Cited by 7 publications

References 38 publications

Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration

Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration

Maternal exposure to cadmium from puberty through lactation induces abnormal reproductive development in female offspring

Elemental concentrations in Choroid-RPE and retina of human eyes with age-related macular degeneration

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