Blood lactate and the lungs: from theory to practice

Анаев, Э. Х.

doi:10.18093/0869-0189-2014-0-6-108-114

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…The concentration of lactate in EBC was measured to be much lower normally in the µM-range (see table 1) than that in the blood [37]. The correlation between lactate concentration in arterial blood and lactate release in exhaled air was reported by Marek and coworkers in a study using young and healthy volunteers performing exercise on an ergometer [27].…”

Section: Methods To Detect Lactate In Breathmentioning

confidence: 54%

Lactate in exhaled breath condensate and its correlation to cancer: challenges, promises and a call for data

Ruzsányi

Kalapos²

2023

J. Breath Res.

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Owing to its connection to cancer metabolism, lactate is a compound that has been a focus of interest in field of cancer biochemistry for more than a century. Exhaled breath volatile organic compounds and condensate analyses can identify and monitor volatile and non-volatile organic compounds, respectively, present in exhaled breath to gain information about the health state of an individual. Whilst the use of exhaled breath condensate for the detection of lactate in exhaled breath is a promising tool that could be used to monitor and screen for cancer, the reliability and sensitivity of detection are uncertain, and hence its value in clinical practice is limited. Currently, lactate present in plasma and exhaled breath condensate can only be used as a biomarker for advanced cancer, and therefore it presently has limited differential diagnostic importance and is rather of prognostic value.

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Section: Methods To Detect Lactate In Breathmentioning

confidence: 54%

Lactate in exhaled breath condensate and its correlation to cancer: challenges, promises and a call for data

Ruzsányi

Kalapos²

2023

J. Breath Res.

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“…При снижении доставки кислорода к клеткам увеличивается продукция молочной кислоты и повышается ее содержание в крови [22], что уже на ранних стадиях отражает уровень тканевой гипоксии. Увеличение уровня лактата -ранний чувствительный маркер несоответствия потребности тканей в кислороде и его доставки, ассоциированный с риском развития осложнений [23].…”

Section: статистическая обработка результатовunclassified

Efficacy and Safety of Some Etiotropic Therapeutic Schemes for Treating Patients With Novel Coronavirus Infection (Covid-19)

Балыкова

Павелкина

Shmyreva

et al. 2020

Farm. farmakol. (Pâtigorsk)

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The aim of the study is to assess the efficacy and safety of the Favipiravir (Areplivir) drug, compared to the standard etiotropic therapy in the patients hospitalized with COVID-19.Material and methods. The research was conducted as a part of an open, randomized, multicenter comparative study of the efficacy and safety of Areplivir, 200 mg film-coated tablets (“PROMOMED RUS” LLC, Russia), in the patients hospitalized with COVID-19. The dosing regimen of Favipiravir was 1600 mg twice a day on the 1st day and 600 mg twice a day on days 2–14. Thirty nine patients were enrolled into the study with a laboratory-established diagnosis of a new type of Coronavirus infection caused by SARS-CoV-2 (confirmed) of moderate severity, with pneumonia. The group of comparison (22 patients) received standard etiotropic therapy, prescribed in accordance with the current version of the temporary guidelines for the diagnosis and treatment of COVID-19, represented mainly by Hydroxychloroquine with the dosage regimen of 800 mg on the 1st day, then 400 mg on days 2–7, and Azithromycin 500 mg once a day for 5 days. The main group (17 patients) received Favipiravir (Areplivir) as etiotropiс therapy.Results. In the main group, the time period until fever disappeared was found to be 1.36 days shorter than in the group of comparison (p<0.05); there was a higher rate of the reduction of inflammatory changes in the lungs according to the computer tomography data (38.4% vs 14.9%, p<0.05). By the end of the treatment, there was also a lower lactate level in the blood (27.1%, p<0.05) than in the patients of the group of comparison. The evaluation of the drug efficacy ассording to the Categorical Ordinal Scale of Clinical Improvement and measurements of oxygen saturation in the blood, manifested similar positive dynamics in the patients treated ассording to various etiotropic therapy regimens. By the end of the treatment, the RNA SARS-CoV-2 tests were also negative in all the patients. As for the overall frequency of adverse events (AEs), no relevant distinctions were found between the groups. A greater part of AEs was related to hepatotoxicity, with a predominantly clinically relevant increase in alanine aminotransferase (ALT). A clinically relevant prolongation of the corrected QT interval on the standard ECG was found to occur in the standard-therapy group on day 5, while no serious AEs were registered in the main group. No serious adverse reactions were registered in patients of the main group.Conclusion. The efficacy of the Favipiravir (Areplivir) therapy for the novel coronavirus infection has proved to be superior to the efficacy of the standard etiotropic therapy in a number of aspects. Basing on the obtained findings, Favipiravir (Areplivir) drug can be recommended for treating patients with the novel coronavirus infection of moderate severity.

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“…Опираясь на данные современных исследователей [1,3,28,31] при обсуждении значимости полученных результатов, необходимо отметить, что умеренно выраженное изменение УПП у пациентов с ВБ в сочетании с метаболическими нарушениями в виде МС и СД2 в височных и центральных отделах ГМ, очевидно, обусловлено усилением анаэробного гликолиза с избыточным высвобождением в экстракле-Рис. 2.…”

Section: обсуждение результатовunclassified

Constant Potential Distribution in Patients With Vibration Disease Combined With Metabolic Disorders

Shevchenko

Лахман

2020

Ekologiya cheloveka (Human Ecology)

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ФГБНУ «Восточно-Сибирский институт медико-экологических исследований», г. Ангарск Цель исследования-выявление особенностей распределения уровня постоянного потенциала (УПП) у пациентов с вибрационной болезнью (ВБ) в сочетании с метаболическими нарушениями. Методы. Обследуемые распределены на группы: I (n = 94)-c ВБ, II (n = 42)-с ВБ, отягощенной метаболическим синдромом (МС), III (n = 31)-с ВБ, отягощенной сахарным диабетом 2 типа (СД2), IV (n = 14)-с СД2, V (n = 50)-группа сравнения. Применены методы статистического анализа с определением W-критерия Шапиро-Уилка, U-критерия Манна-Уитни, дискриминантный анализ. Результаты. В I-IV группах доля лиц с измененной нейроэнергетической активностью выше, чем в группе сравнения (p = 0,001; 0,003; 0,01; 0,009 соответственно). В I группе УПП преобладал в центральном, во II-в левом центральном, правом височном, в III-в левом центральном, центральном, в IV-в правом лобном, центральных, левом теменном отведениях при сопоставлении с V группой при p < 0,01. У пациентов II-IV групп диагностировано

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Blood lactate and the lungs: from theory to practice

Cited by 6 publications

References 27 publications

Lactate in exhaled breath condensate and its correlation to cancer: challenges, promises and a call for data

Lactate in exhaled breath condensate and its correlation to cancer: challenges, promises and a call for data

Efficacy and Safety of Some Etiotropic Therapeutic Schemes for Treating Patients With Novel Coronavirus Infection (Covid-19)

Constant Potential Distribution in Patients With Vibration Disease Combined With Metabolic Disorders

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