Blood Histamine and Basophil Leukocytes in Polycythemia

Brandt, L.; Cederquist, Ebbe; Rorsman, H; Tryding, Nils

doi:10.1111/j.0954-6820.1964.tb00682.x

Cited by 6 publications

(2 citation statements)

References 10 publications

(7 reference statements)

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“…The observed elevation was, however, only moderate and 6 of 29 PV patients had values within the normal range. This is in accordance with earlier reports (Brandt et al 1964, Gilbert et a1 1966. All patients with secondary polycythaemia had normal values.…”

Section: Discussionsupporting

confidence: 94%

Histamine Metabolism in Polycythaemia Vera

Westin

Granérus

Weinfeld

et al. 1975

Scandinavian Journal of Haematology

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Histamine metabolism was studied in 35 patients with polycythaemia Vera (PV) at different stages of their disease and compared with controls and patients with secondary polycythaemia. In addition to blood and urinary histamine the main urinary metabolites of histamine, methylhistamine (MeHi) and 1-methyl-4-imidazoleacetic acid (MeImAA) were measured. In patients with active PV the excretion of MeHi and MeImAA was significantly higher than in controls and secondary polycythaemia, indicating an increased histamine formation. The MeImAA excretion was correlated to the blood histamine level, the degree of blood basophilia, the total white blood count and the spleen volume. The blood histamine level was significantly higher in PV patients compared with controls and secondary polycythaemia. No patients with secondary polycythaemia had an increased blood histamine level. With the bio-assay technique used in this study the urinary excretion of histamine in the PV patients was within the normal range. There was no correlation between the increased hstamine formation and 'histaminerelated symptoms'. Pruritus and duodenal ulcer occurred with a similar frequency in patients with and without increased MeImAA excretion. The similarity between the disturbance of the histamine metabolism in PV and that found by other authors in chronic myeloid leukaemia is pointed out.

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Section: Discussionsupporting

confidence: 94%

Histamine Metabolism in Polycythaemia Vera

Westin

Granérus

Weinfeld

et al. 1975

Scandinavian Journal of Haematology

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“…Histamine in blood was measured fluorometrically (Brandt et al 1964). Histamine in urine was determined by bioassay (Wetterqvist & White 1970).…”

Section: E T H O D Smentioning

confidence: 99%

Urinary Excretion of Histamine and Histamine Metabolites in Leukaemia

Berg

Granérus

Westling

et al. 1971

Scandinavian Journal of Haematology

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Most patients with chronic myelocytic leukaemia (12 cases in this material) excreted much larger quantities (up to twenty times normal) of histamine metabolites in the urine than healthy individuals and patients with other forms of leukaemia. This indicated an increased rate of formation of histamine in chronic myelocytic leukaemia. The site and mechanism of this increased histamine formation is discussed in relation the metabolic pattern found.

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Histamine Excess Symptoms in Basophilic Chronic Granulocytic Leukemia

Youman¹

1973

Arch Intern Med

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Blood Histamine and Basophil Leukocytes in Polycythemia

Cited by 6 publications

References 10 publications

Histamine Metabolism in Polycythaemia Vera

Histamine Metabolism in Polycythaemia Vera

Urinary Excretion of Histamine and Histamine Metabolites in Leukaemia

Histamine Excess Symptoms in Basophilic Chronic Granulocytic Leukemia

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