Histamine Excess Symptoms in Basophilic Chronic Granulocytic Leukemia

Youman, J. Dudley

doi:10.1001/archinte.1973.00320100088012

Cited by 29 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cutaneous lesions had the same aspect, characterized by urticarian rashes in patches, disappearing with the drop in blast cell counts and the achievement of complete remission. Similar allergic-like lesions have been reported in CML and myeloproliferative diseases with high basophil counts, and have been related to histamine release from mature basophils (Youman et al, 1973;Rosenthal et al, 1977). The same cutaneous aspects have also been described in immature basophilic leukaemias and their severity correlated with the number of metachromatic cells (Wick et al, 1982;Kurosawa et al, 1987).…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Acute basophilic leukaemia and translocation t(X;6)(p11;q23)

Dastugue¹,

Duchayne²,

Kühlein

et al. 1997

Br J Haematol

View full text Add to dashboard Cite

Summary.We report two infants with acute basophilic leukaemia associated with a t(X;6)(p11;q23) as the sole abnormality. Morphologic evidence of basophilic lineage was provided by light and electron microscopy. Both patients also had a similar presentation on diagnosis, characterized by clinical signs consistent with a hyperhistaminaemia syndrome, i.e. urticarian rashes and gastro-intestinal disorders evocative of peptic ulcer. Immunophenotypes differed in the two patients, one expressing CD24, CD13 and CD33, whereas only CD117 was found in the other.Basophilic acute leukaemia, a rare group among acute leukaemias, might be nonrandomly associated with a specific chromosomal abnormality, t(X;6)(p11;q23). This new entity might also be identifiable by an uncommon clinical presentation and occurrence in infancy.

show abstract

Section: Discussionsupporting

confidence: 69%

“…These clinical manifestations might be caused by hypersecretion of gastric acid and pepsin, not documented in our patients, but already described in malignancies with extreme basophilia and subsequent hyperhistaminaemia (Youman et al, 1973;Rosenthal et al, 1977;Anderson et al, 1988;Olinger et al, 1976).…”

Section: Discussionsupporting

confidence: 65%

Acute basophilic leukaemia and translocation t(X;6)(p11;q23)

Dastugue¹,

Duchayne²,

Kühlein

et al. 1997

Br J Haematol

View full text Add to dashboard Cite

show abstract

“…Basophilia is often en countered in patients with chronic myeloproliferative dis orders, and symptoms due to basophilia-associated hyper histaminemia were reported [13][14][15]. The severity of the symptoms seemed to depend on the level of histamine, es pecially in plasma.…”

Section: Discussionmentioning

confidence: 98%

“…The symptoms of hyperhistaminemia via H2 receptors actually seemed to be prevented by treatment with an H2 receptor antagonist, fa motidine, whereas wheezing, the symptom mediated by H, receptors, was improved by administration of chlorpheni ramine. Treatment with antihistaminic agents was re ported to result in marked improvement in symptoms of hyperhistaminemia in patients with basophilic chronic granulocytic leukemia [13,14]. Severe symptoms such as shock, peptic ulceration and flushing were reported after treatment with all-tmns retinoic acid in a patient with APL and basophilia although a histamine H2-rcccptor antag onist had been administered [3], but wheezing was not re ported.…”

Section: Discussionmentioning

confidence: 99%

Prophylaxis of Symptoms of Hyperhistaminemia after the Treatment of Acute Promyelocytic Leukemia with <i>All-Tran</i><i>s</i> Retinoic Acid

et al. 1994

View full text Add to dashboard Cite

A 61-year-old man with acute promyelocytic leukemia (APL) is described in whom some leukemic promyelocytes contained granules similar to those of basophils, and hyperhistaminemia developed after treatment with all-trans retinoic acid. The symptoms of hyperhistaminemia, mediated via H₂ receptors, were prevented by the administration of an H₂-blocker, famotidine, but wheezing due to bronchospasms, mediated via H₁ receptors, developed and was improved by administration of chlorpheniramine. In APL, it is generally thought that the maturation of neutrophilic leukocytes is arrested at the level of abnormal promyelocytes. However, heterogeneity of leukemic promyelocytes has been described and in a few patients some leukemic promyelocytes have been known to show basophilic features. Marked basophilia and severe symptoms due to hyperhistaminemia have recently been reported after the treatment of APL with ali-trans retinoic acid. Our case presented similar basophilic features, but indicated that the symptoms of hyperhistaminemia after administration of retinoic acid can be prevented with antihistaminic drugs and suggested that both H₁ and H₂- blockers should be administered to such APL patients with basophilia.

show abstract

“…Hypotension as a paraneoplastic syn drome has been described in several malig nancies including carcinoid, chronic baso philic leukemia and mastocytosis [7][8][9]. In each case, vasoactive substances secreted by the tumor are believed to cause the hypoten sion.…”

Section: Discussionmentioning

confidence: 99%

Unexplained Hypotension in Hodgkin’s Disease

Studemeister¹,

Ptacin²,

Cunningham³

et al. 1988

Cardiology

View full text Add to dashboard Cite

A 51 -year-old black male with progressive polymyositis presented to our hospital with respiratory failure. Hemodynamic monitoring revealed tachycardia, arterial hypotension, a high cardiac index, and low systemic vascular resistance. Evaluation for common etiologies of this hemodynamic pattern was unrewarding. He was found to have Hodgkin’s disease of the bone marrow. Aggressive combination chemotherapy led to normalization of heart rate and arterial pressure. It is postulated that Hodgkin’s disease through some undetermined mechanism can cause a hyperdynamic circulatory pattern. This hemodynamic state reversed with suppression of the tumor

show abstract

Histamine Excess Symptoms in Basophilic Chronic Granulocytic Leukemia

Cited by 29 publications

References 8 publications

Acute basophilic leukaemia and translocation t(X;6)(p11;q23)

Acute basophilic leukaemia and translocation t(X;6)(p11;q23)

Prophylaxis of Symptoms of Hyperhistaminemia after the Treatment of Acute Promyelocytic Leukemia with <i>All-Tran</i><i>s</i> Retinoic Acid

Unexplained Hypotension in Hodgkin’s Disease

Contact Info

Product

Resources

About

Histamine Excess Symptoms in Basophilic Chronic Granulocytic Leukemia

Cited by 29 publications

References 8 publications

Acute basophilic leukaemia and translocation t(X;6)(p11;q23)

Acute basophilic leukaemia and translocation t(X;6)(p11;q23)

Prophylaxis of Symptoms of Hyperhistaminemia after the Treatment of Acute Promyelocytic Leukemia with <i>All-Tran</i><i>s</i> Retinoic Acid

Unexplained Hypotension in Hodgkin&rsquo;s Disease

Contact Info

Product

Resources

About

Unexplained Hypotension in Hodgkin’s Disease