Blood groups of anthropoid apes and their relationship to human blood groups

Socha, W. W.; Moor‐Jankowski, J.

doi:10.1016/0047-2484(79)90083-6

Cited by 34 publications

(23 citation statements)

References 17 publications

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“…Moreover, the presence of the ABO polymorphism throughout primates implies that the selected phenotype is probably not tied to the expression of antigens on red blood cells, a trait restricted to hominoids (35). Humans are known to have many histo-blood subgroups (notably among A types), which are interchangeable for transfusion purposes, but differ in quantity and quality of antigens (36,37); similarly, chimpanzees, gorillas, orangutans, and gibbons have been reported to have variable A and B subgroups, respectively, that differ in antigenic properties (26,38). Thus, although A, B, and O are clearly of functional importance and may denote the strongest fitness differences Fig.…”

Section: Discussionmentioning

confidence: 99%

The ABO blood group is a trans-species polymorphism in primates

Ségurel

Thompson²,

Flutre

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

139

177

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Fig. 1. The phylogenetic distribution of ABO phenotypes and genotypes. Shown is a phylogenetic tree of primate species, with a summary of phenotypic/ genotypic information given in the first column, and the genetic basis for the A versus B phenotype provided in the second column (functionally important codons at positions 266 and 268 are in uppercase letters). See Dataset S1 for the source of information about phenotypes/genotypes. Only species with available divergence times are represented here (34 of 40). The phylogenetic tree is drawn to scale, with divergence times (on the x axis) in millions of years taken from ref. 29. OWM, Old World monkeys; NWM, New World monkeys. Under a model of convergent evolution, these data suggest that A is the ancestral allele, and a turnover (e.g., a neutral substitution) occurred on the branch leading to Old World monkeys. If instead, B were ancestral, all Old World monkeys would have had to serendipitously converge from ATG to TTG to encode a leucine, whereas all New World monkeys and hominoids would have had to converge to the CTG codon.

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Section: Discussionmentioning

confidence: 99%

The ABO blood group is a trans-species polymorphism in primates

Ségurel

Thompson²,

Flutre

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

139

177

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“…The M and N activity of the chimpanzee, respectively, are sensitive to trypsin and chymotrypsin. A reasonable speculation for this observation is that the M and N specificities are carried separately on at least two different kinds of glycophorins on the chimpanzee RBCs [19,20].…”

Section: Discussionmentioning

confidence: 99%

Human-type blood group activities on chimpanzee erythrocytes with special reference to M and N

et al. 1988

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Human-type blood group activities on the red blood cells (RBCs) of three chimpanzees were individually examined with commercial mouse monoclonal antibodies (anti-A, -B, -H, -M, -N, -Lea, and -Leb) as well as lectins (UEA-I and VGA) and conventional polyclonal antisera for the systems ABO, MN, Lewis, Rh-Hr, P, Kell, Kidd, Duffy, and Lutheran. For further analysis of the MN antigens, treatment of the RBCs with sialidase, trypsin, and chymotrypsin were employed. The activities recognized among the three chimpanzees were A, H, M, N, Leb, c, S, k, and Jka. The RBCs of the three individuals possessed the A antigen which showed the same serologic activity as the human A1. Those chimpanzee RBCs showed higher H-activity than the human A1 RBCs. The Lewis b activity was revealed by the absorption-elution method. The RBCs of the three individuals showed a reactivity to the polyclonal anti-M reagents, which was affected by both the sialidase and trypsin treatment. The RBCs of two individuals were agglutinated with the monoclonal anti-N. The receptor was sensitive to sialidase and chymotrypsin. The RBCs of the three individuals, however, did not react with the monoclonal anti-M or with one of the polyclonal anti-N. These results indicate structural differences in the glycophorins and MN antigens between the human and chimpanzee.

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“…In addition, serological studies have indicated that the chimpanzee erythroeytes are characterized by a complex blood-group system, the V-A-B-D system (Wiener et al, 1974). This system has been found to be an extension of the human MN system (Socha and Moor-Jankowski, 1979). Therefore the antigenic diversity of the MN blood group system is markedly more pronounced among the chimpanzees than in the human.…”

Section: Introductionmentioning

confidence: 97%

Polymorphisms and gross structure of glycophorin genes in common chimpanzees

Huang

Socha

et al. 1990

Biochem Genet

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Using human alpha glycophorin cDNA probe and six restriction enzymes, we examined the homologues of human glycophorin genes in genomic DNA of 11 unrelated chimpanzees. We show that, in contrast to the human, the chimpanzee exhibits an unusual array of nonrandomly distributed restriction fragment length polymorphisms (RFLP). No clear correlation was found between the RFLP and the V-A-B-D blood-group phenotypes of the subjects, with one possible exception. However, pairs of allelic RFLP occurring at a relatively high frequency were identified. In addition, the homology of chimpanzee glycophorin genes to the human genes was examined using as probes synthetic oligonucleotides specifying distinct regions of human glycophorin genes. We show that the glycophorin gene family in the chimpanzee consists of at least three members that are homologous to the human alpha, delta, and E genes (glycophorins A, B, and E) and may share a similar gross structure and overall organization.

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Blood groups of anthropoid apes and their relationship to human blood groups

Cited by 34 publications

References 17 publications

The ABO blood group is a trans-species polymorphism in primates

The ABO blood group is a trans-species polymorphism in primates

Human-type blood group activities on chimpanzee erythrocytes with special reference to M and N

Polymorphisms and gross structure of glycophorin genes in common chimpanzees

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