Blood group substances, Forssman and mononucleosis antigens in lipid-containing RNA viruses

Rott, R.; Drzeniek, R.; Saber, Mohamed; Reichert, E

doi:10.1007/bf01241850

Cited by 43 publications

(17 citation statements)

References 25 publications

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“…The PROSTVAC-VF poxviruses are propagated in chicken embryo dermal cells, which are known to biosynthesize blood group A-like glycans (38). Vaccinia (39) and other vaccines (40, 41) produced in chicken cells have long been recognized to contain a blood group A-like glycan. Therefore, we hypothesized that the BG-A tri antibodies detected in our array profiling may recognize glycans on the viral vectors.…”

Section: Resultsmentioning

confidence: 99%

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF

Campbell

Gulley

Oyelaran

et al. 2013

Clinical Cancer Research

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Purpose There is evidence that therapeutic cancer vaccines can lengthen survival for some cancer patients, but responses vary widely from one person to another. Methods to predict clinical outcomes will advance the field and provide new insights into critical determinants of in vivo efficacy. Experimental Design This retrospective study included 141 subjects from phase II trials of PROSTVAC-VF, a poxvirus based cancer vaccine currently in phase III clinical trials for advanced prostate cancer. A glycan microarray was used to profile pre-vaccination anti-glycan antibody populations in sera as potential biomarkers for PROSTVAC-VF. The screen for predictive biomarkers identified anti-glycan antibodies that consistently stratified subjects into groups with different Kaplan Meier survival estimates. Due to the potential for overfitting, a permutation test was used to estimate the false discovery rate. Results Pre-vaccination antibody levels to blood group A trisaccharide (BG-Atri) were found to have a statistically significant correlation with survival. Long-term survival was approximately doubled in subjects with abundant anti-BG-Atri IgM relative to subjects with little or no pre-existing IgM for BG-Atri. This survival correlation was specific to vaccine treatment, as no correlation was observed in control patients immunized with wild-type poxviruses lacking the key tumor antigen, prostate specific antigen (PSA). Moreover, anti-BG-Atri IgM levels were not correlated with general measures of disease severity, such as PSA levels, Gleason score, or Halabi predicted survival. Conclusion In addition to reporting a new potentially predictive biomarker for PROSTVAC-VF, this study highlights the utility of glycan microarray technology for improving our understanding of vaccine immunology.

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Section: Resultsmentioning

confidence: 99%

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF

Campbell

Gulley

Oyelaran

et al. 2013

Clinical Cancer Research

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“…Unlike the myxoviruses and rhabdoviruses, the paramyxoviruses do have enough genetic information to code for a few glycosyl transferases, but there is no evidence that they do so. Host cell carbohydrate antigens such as blood group or Forssman antigens have been found to be associated with paramyxoviruses (Isacson and Koch, 1965;Rott et al, 1966).…”

Section: Carbohydratesmentioning

confidence: 99%

Reproduction of Paramyxoviruses

Choppin

Compans

1975

Comprehensive Virology

187

115

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“…Influenza and Newcastle disease viruses are known to incorporate host materials into their envelopes (1,2,3,4,5,6,30,31,32). Sindbis, an arbovirus, contains host-derived antigens (4).…”

Section: Discussionmentioning

confidence: 99%

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

Lindenmann

Klein

1967

The Journal of Experimental Medicine

215

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A2G mice could be solidly immunized against the Ehrlich ascites tumor by single intraperitoneal injections of homogenized and lyophilized tumor cells which had been infected with oncolytic strains of influenza A virus. Similar homogenates from noninfected tumor cells were not immunogenic, even when mixed with egg-grown virus. The immunizing principle in viral oncolysates could not be separated from the oncolytic virus by differential centrifugation or adsorption to and elution from red cells. It could be inhibited by antibody raised in rabbits against the egg-grown oncolytic virus. This reaction showed serologic specificity. Thus, the immunogenicity of an oncolysate produced with the WSA strain of neurotropic influenza virus could be inhibited by rabbit anti-WSA, but not by rabbit antibody to the TUR strain of fowl plague virus. Conversely, the immunogenicity of an oncolysate prepared with the TUR strain could be inhibited by rabbit anti-TUR, but not by anti-WSA. When mice were preimmunized (primed) with egg-grown WSA virus, their antitumor response to a later injection of WSA oncolysate was of the anamnestic type. Priming with egg-grown influenza B virus had no such effect. It was concluded that the immunogenicity of certain host cell components was greatly increased by incorporation into the makeup of the oncolytic virus.

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Blood group substances, Forssman and mononucleosis antigens in lipid-containing RNA viruses

Cited by 43 publications

References 25 publications

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF

Reproduction of Paramyxoviruses

Viral Oncolysis: Increased Immunogenicity of Host Cell Antigen Associated With Influenza Virus

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