SUMMARYDense poliovirus particles (buoyant density I"44 g/ml in CsC1) isolated from infected HeLa cells contain the normal four structural polypeptides VPI to VP4, and 35 S poliovirus RNA. In addition, small amounts of VPo and single-stranded RNA sedimenting slower than the poliovirus genome are present. Dense particles have a low specific infectivity, are neutralized by type-specific poliovirus antisera, and are detected during growth as early as normal virus but disappear when virus production stops. They appear to represent a different, more open, conformation of the normal virus capsid.
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