Blood Group and Tissue Mosaicism in a Natal Indian Woman

Abstract

A normal 46, XX karyotype was demonstrated in an Indian woman who has 2 approximately equal populations of red cells and of leucocytes. She also has skin mosaicism. She is a normal female and has borne 4 healthy children. The ABO, Ss, Rh and Fy groups of her 2 red cell populations differed, but both were Le(a+b-) although she is a secretor of B and H substances. The relationship between this and the 7 examples of dispermywith blood group mosaicism reported in the literature is discussed briefly

Blood Group Chimeras

“…This theory of intracellular interaction was sup ported by the secretions observed in Mrs. T.R., the first Durban chimera [48], Both Mr. D.W. and Mrs. T.R. were Le(a + b-) but secretors of ABH, a surprising …”

Preface and Acknowledgements

“…A more detailed investigation of the distribution of the light-and dark-brown skin pigmentation in Mrs T.R. than had been possible in the first study (Moores, 1973) was reported by Findlay and Moores in 1980. Fundamentally, Mrs T.R.…”

“…A fresh blood sample from Mrs T.R. 's mother, 1-2, was found to be Le(a+b-), showing that the Le(a-) result recorded earlier (Moores, 1973) had been incorrect. However, fortunately , this made no difference to the interpretation of the inheritance in the family.…”

“…Unlike the other six dispermic chimaeras then known, she was fertile, having had four normal, healthy children. Her skin showed patchy pigmentation and she had two populations of red cells and of leucocytes in her blood (Moores, 1966;Moores, 1973).…”

Zulu XX/XX Dispermie Chimaera from Natal with Two Populations of Red Blood Cells and Patchy Skin Pigmentation

“…The sepa rate genetic origins of their cell lines distinguish chimaer as from mosaics who characteristically originate from a single zygote [2]. The literature contains counts of XX/XY hermaphrodite but few of XX/XX female disper mie chimaeras [1], The first 2 females with double pop ulations of red cells recorded were both from Natal [1,[3][4][5], Mayr et al [6] reported the 3rd female but two populations of red cells were not observed in her blood.…”