Blood glucose and body temperature alterations induced by ethanol in rats submitted to different levels of food deprivation

Souza, Maria Lucia Oliveira; Masur, Jandira

doi:10.1016/0091-3057(81)90206-9

Cited by 20 publications

(2 citation statements)

References 13 publications

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“…The results presented in Figure 1 show that ethanol treatment resulted in a dosedependent reduction in body temperature, in agreement with previous results (20,29). ANOVA revealed that dexamethasone produced a significant antagonism of the hypothermic effect of 2.…”

supporting

confidence: 81%

Ethanol-induced hypothermia in rats is antagonized by dexamethasone

Carreño¹,

Ferreira²,

Morato³

1997

Braz J Med Biol Res

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The effect of dexamethasone on ethanol-induced hypothermia was investigated in 3.5-month old male Wistar rats (N = 10 animals per group). The animals were pretreated with dexamethasone (2.0 mg/kg, ip; volume of injection = 1 ml/kg) 15 min before ethanol administration (2.0, 3.0 and 4.0 g/kg, ip; 20% w/v) and the colon temperature was monitored with a digital thermometer 30, 60 and 90 min after ethanol administration. Ethanol treatment produced dose-dependent hypothermia throughout the experiment (-1.84 ± 0.10, -2.79 ± 0.09 and -3.79 ± 0.15 o C for 2.0, 3.0 and 4.0 g/kg ethanol, respectively, 30 min after ethanol) but only the effects of 2.0 and 3.0 g/kg ethanol were significantly antagonized (-0.57 ± 0.09 and -1.25 ± 0.10, respectively, 30 min after ethanol) by pretreatment with dexamethasone (ANOVA, P<0.05). These results are in agreement with data from the literature on the rapid antagonism by glucocorticoids of other effects of ethanol. The antagonism was obtained after a short period of time, suggesting that the effect of dexamethasone is different from the classical actions of corticosteroids.

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supporting

confidence: 81%

Ethanol-induced hypothermia in rats is antagonized by dexamethasone

Carreño¹,

Ferreira²,

Morato³

1997

Braz J Med Biol Res

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“…Acute ethanol administration in normally feeding rodents results in a mild but prolonged hyperglycemia (Oliveira de Souza and Masur, 1981; Souza and Masur, 1982, 1984; Risinger and Cunningham, 1991, 1992; Risinger, 2003), due in part to increased glycogenolysis and decreased glyconeogenesis (see van de Wiel, 2004 for review). Ethanol also acutely inhibits signaling through the insulin receptor (e.g.…”

Section: Introductionmentioning

confidence: 99%

Insulin attenuates the acquisition and expression of ethanol-induced locomotor sensitization in DBA/2J mice

Kliethermes

Heberlein

2011

Life Sciences

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Aims Ethanol-induced locomotor sensitization is a behavioral manifestation of physiological responses to repeated ethanol exposures. While ethanol exerts direct effects on multiple neurotransmitter systems in the brain, ethanol-induced changes in metabolic state, including acute hyperglycemia and inhibition of insulin signaling, also have plausible roles in the expression of ethanol-related behaviors through direct and indirect effects on brain function. The current experiments examined whether insulin administration or the resultant hypoglycemia might attenuate the development of sensitization to the locomotor stimulant effect of ethanol. Main methods Male and female DBA/2J mice received daily injections of 5 or 10 IU/kg insulin before or after a stimulating dose of ethanol and subsequent testing in an automated activity monitor. Blood glucose levels were determined upon the completion of the experiments. Key findings Insulin injected prior to ethanol blunted the acute stimulant response as well as the acquisition and expression of locomotor sensitization, while insulin given after ethanol did not affect the development of the sensitized response. In a separate experiment, mice given glucose concurrently with insulin developed ethanol-induced locomotor sensitization normally. Significance These experiments suggest that insulin attenuates the development of ethanol-induced locomotor sensitization, and that blood glucose levels can largely account for this effect. Further studies of the role of ethanol-induced metabolic states should provide novel information on the expression of ethanol-related behaviors.

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Ethanol-induced hypothermia and hyperglycemia in genetically obese mice

Haller

Wittmers

1989

Life Sciences

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Blood glucose and body temperature alterations induced by ethanol in rats submitted to different levels of food deprivation

Cited by 20 publications

References 13 publications

Ethanol-induced hypothermia in rats is antagonized by dexamethasone

Ethanol-induced hypothermia in rats is antagonized by dexamethasone

Insulin attenuates the acquisition and expression of ethanol-induced locomotor sensitization in DBA/2J mice

Ethanol-induced hypothermia and hyperglycemia in genetically obese mice

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