“… 1 , 2 , 3 , 4 , 5 , 6 For this reason, BFR training has shown particular promise for special populations such as elderly patients, physically impaired patients, and presurgical or postsurgical patients who are otherwise unable to tolerate high-load resistance training. 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 Although the exact mechanisms contributing to the observed increases in muscle mass, muscular strength, and cardiorespiratory function associated with BFR training continue to be investigated, it is thought that the reduction in blood flow produces localized hypoxia and metabolic stress that accelerates fatigue accumulation (e.g., reduced repetitions to failure), resulting in the enhanced recruitment of type II muscle fibers, as well as stimulation of anabolic pathways and hormone secretion. 18 , 19 , 20 , 21 , 22 …”