Blood flow and ionic responses in the awake brain due to carbon monoxide

Mendelman, Avivit; Zarchin, N.; Meilin, Sigal; Guggenheimer-Furman, Esther; Thom, Stephen R.; Mayevsky, Avraham

doi:10.1179/016164102101200861

Cited by 14 publications

(6 citation statements)

References 25 publications

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“…Exchange transfusion with blood containing 80% CO-Hgb to otherwise healthy dogs resulted in no toxic effects, however, despite resultant CO-Hgb levels of 57% to 64%, suggesting that CO toxicity is not dependent on CO-Hgb formation. Other studies have corroborated the findings of morbidity and mortality due to CO poisoning independent of hypoxia or CO-Hgb formation [45][46][47][48][49].…”

Section: Direct Cellular Toxicitymentioning

confidence: 75%

Carbon monoxide poisoning

Kao¹,

Nañagas²

2004

Emergency Medicine Clinics of North America

167

171

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Section: Direct Cellular Toxicitymentioning

confidence: 75%

Carbon monoxide poisoning

Kao¹,

Nañagas²

2004

Emergency Medicine Clinics of North America

167

171

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“…Carbon monoxide (CO) is a toxic gas that can act as a cerebral vasodilator. 2 , 3 Increases in CBF with elevations in CO have been shown in animal models 3 – 7 as well as in humans. 8 , 9 Low-level CO exposure is common, through inhalation of cigarette smoke or air pollution.…”

Section: Introductionmentioning

confidence: 98%

Low-level carbon monoxide exposure affects BOLD fMRI response

Bendell

Moosavi

Herigstad

2019

J Cereb Blood Flow Metab

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Blood oxygen level dependent (BOLD) fMRI is a common technique for measuring brain activation that could be affected by low-level carbon monoxide (CO) exposure from, e.g. smoking. This study aimed to probe the vulnerability of BOLD fMRI to CO and determine whether it may constitute a significant neuroimaging confound. Low-level (6 ppm exhaled) CO effects on BOLD response were assessed in 12 healthy never-smokers on two separate experimental days (CO and air control). fMRI tasks were breath-holds (hypercapnia), visual stimulation and fingertapping. BOLD fMRI response was lower during breath holds, visual stimulation and fingertapping in the CO protocol compared to the air control protocol. Behavioural and physiological measures remained unchanged. We conclude that BOLD fMRI might be vulnerable to changes in baseline CO, and suggest exercising caution when imaging populations exposed to elevated CO levels. Further work is required to fully elucidate the impact on CO on fMRI and its underlying mechanisms.

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“…Dora et al (68) were able to change the NADH redox state when CO was applied topically to the brain. Our group showed in detail the influence of various CO levels on the pathophysiology of the brain in vivo (173,186,188,212). When CO levels were low, the NADH remained the same; whereas Ͼ3,000 ppm, CO led to an increase in NADH due to the development of hypoxia.…”

Section: Hyperoxia or Normobaric And Hyperbaric Increase In Po2mentioning

confidence: 99%

Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies

Mayevsky¹,

Rogatsky²

2007

American Journal of Physiology-Cell Physiology

Self Cite

326

290

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Mayevsky A, Rogatsky GG. Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies. Am J Physiol Cell Physiol 292: C615-C640, 2007. First published August 30, 2006; doi:10.1152/ajpcell.00249.2006.-Normal mitochondrial function is a critical factor in maintaining cellular homeostasis in various organs of the body. Due to the involvement of mitochondrial dysfunction in many pathological states, the real-time in vivo monitoring of the mitochondrial metabolic state is crucially important. This type of monitoring in animal models as well as in patients provides real-time data that can help interpret experimental results or optimize patient treatment. The goals of the present review are the following: 1) to provide an historical overview of NADH fluorescence monitoring and its physiological significance; 2) to present the solid scientific ground underlying NADH fluorescence measurements based on published materials; 3) to provide the reader with basic information on the methodologies used in the past and the current state of the art fluorometers; and 4) to clarify the various factors affecting monitored signals, including artifacts. The large numbers of publications by different groups testify to the valuable information gathered in various experimental conditions. The monitoring of NADH levels in the tissue provides the most important information on the metabolic state of the mitochondria in terms of energy production and intracellular oxygen levels. Although NADH signals are not calibrated in absolute units, their trend monitoring is important for the interpretation of physiological or pathological situations. To understand tissue function better, the multiparametric approach has been developed where NADH serves as the key parameter. The development of new light sources in UV and visible spectra has led to the development of small compact units applicable in clinical conditions for better diagnosis of patients.real-time tissue viability; tissue spectroscopy; patient monitoring UNDERSTANDING THE MITOCHONDRIAL function has been a challenge for many investigators, including cytologists, biochemists, and physiologists, since its discovery more than 120 years ago. In addition to many books regarding the mitochondria, Ernster and Schatz (79) reviewed the history of mitochondrial structure and function studies. In the past two decades, several studies have reported mitochondrial involvement in pathological processes such as stroke (225) or cytoprotection (77). Most of the information on the mitochondrial function has been accumulated from in vitro studies. A relatively small portion of published papers dealt with the monitoring of mitochondrial function in vivo and in real time. Presently, examination of the involvement of the mitochondrial function in many pathological states, such as sepsis, requires monitoring of patients treated in intensive care units. Unfortunately, real-time monitoring of the mitochondrial function in patients has rarely been performed. The current study pres...

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Blood flow and ionic responses in the awake brain due to carbon monoxide

Cited by 14 publications

References 25 publications

Carbon monoxide poisoning

Carbon monoxide poisoning

Low-level carbon monoxide exposure affects BOLD fMRI response

Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies

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