Blood Culture Isolates in Neonatal Sepsis and their Sensitivity in Anand District of India

Patel, Dipak V.; Nimbalkar, Archana; Sethi, Ankur; Kungwani, Amit; Nimbalkar, Somashekhar

doi:10.1007/s12098-013-1314-2

Cited by 19 publications

(19 citation statements)

References 22 publications

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“…While in some studies it has been reported as high as 44.7% (Ethiopia) (12) and 45.9% (Nigeria) (13), in other studies it is about 20% (14). It was 11.9% in this study, which can be explained by the different clinical criteria for suspicion of sepsis and taking blood samples, the technique of culture (traditional culture vs. BACTEC), quality of life and measures of health care and hospital services in various countries (15,16).…”

Section: Bloodmentioning

confidence: 78%

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Behmadi

Borji

Taghavi-Rad

et al. 2016

Arch Pediatr Infect Dis

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Background: Neonatal sepsis is a systemic inflammatory response syndrome that is secondary to infection. It is a major cause of neonatal mortality in the world, particularly in developing countries. A definitive diagnosis requires the isolation of pathogens from a normally sterile body site, including blood, cerebrospinal fluid and urine. Empirical antibiotic therapy is based on the physician's knowledge of the anticipated bacterial species and their expected antibiotic susceptibilities. Objectives: The aim of this study was to determine the prevalence and evaluate the antimicrobial susceptibility patterns of bacterial infections at a neonatal unit. Patients and Methods:This study was conducted at the neonatal intensive care unit and neonatal ward of Hakim hospital, Neyshabour, Iran. Blood, cerebrospinal fluid (CSF) and urine specimens were collected before institution of empirical antibiotic therapy. Antibiotic resistance pattern of the isolates was studied by the disc diffusion technique. Results: Coagulase-negative staphylococci (CoNS) were the most prevalent pathogens isolated from blood specimens in early and late-onset disease. Escherichia coli and Klebsiella were the most causative pathogens in early and late-onset urinary tract infections. They had high resistance to our empirical antibiotic regimens. Prevalence of bacterial meningitis was low in our study. Conclusions: Due to the increasing resistance of pathogens to usual empirical antibiotics, it is reasonable to stress upon preventive measures, so that a minimum number of neonates develop sepsis.

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Section: Bloodmentioning

confidence: 78%

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Behmadi

Borji

Taghavi-Rad

et al. 2016

Arch Pediatr Infect Dis

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“…12 Incidence of polymicrobial sepsis was 5.95% in our study. While it was reported to be 5.2% by Shrestha,6.8% by Kumhar et al and 3.92% by Viswanathan. 4,12.13 Nepal et al did not find any case of polymicrobial sepsis.…”

Section: Discussionmentioning

confidence: 91%

“…3 Whereas, many studies reported Klebsiella to be the most common organism. 4,[6][7][8][9] Some authors had found Staphylococcus aureus as the most common organism. 10,11 Intrapartum antibiotic prophylaxis has also led to a substantial change in the bacterial flora responsible for early onset neonatal sepsis.…”

Section: Discussionmentioning

confidence: 99%

Bacteriological profile and antimicrobial sensitivity pattern in neonatal sepsis: a study from North India

et al. 2017

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Background: Neonatal sepsis is a leading cause of neonatal mortality and continues to be a formidable problem for neonatologists and pediatricians world over. Knowledge of microbial flora and their susceptibility will help us to decide empirical treatment for the neonatal sepsis. The objective of this study was to determine the bacteriological flora prevalent in NICU and the antimicrobial sensitivity pattern.Methods: The blood culture reports of all the neonates with culture proven neonatal sepsis during the period July 2010 to September 2013 were reviewed retrospectively. A retrospective review in tertiary care teaching medical college. The data was entered in Excel sheets and percentages of various outcomes were calculated.Results: A total of 28,927 babies were born during the study period and 336 among them had positive blood culture. The incidence of neonatal sepsis was 11.62 per 1,000 live births. Three hundred fifty- six microbes were isolated, out of which 50% presented as early onset sepsis and remaining as late onset sepsis. Pseudomonas aeruginosa was the most common organism encountered in both early (43.82%) and late onset sepsis (51.35%). Gram negative bacilli were sensitive to carbapenems (92%) followed by piperacillin-tazobactam (90%) whereas linezolid (90%) was most sensitive antimicrobial for gram positive cocci.Conclusions: Pseudomonas was most commonly isolated in both early and late onset sepsis. Gram negative bacilli were most sensitive to piperacillin-tazobactam and the carbapenems whereas linezolid and vancomycin were most effective against the gram-positive cocci. Resistance to third generation cephalosporins was rampant. Continuous surveillance for microbial flora, their antibiotic susceptibility, rational use of antibiotics and the strategy of antibiotic cycling may be of help to curtail emerging antimicrobial resistance.

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“…Blood culture though "gold standard", takes a lot of time for diagnosis. 2 Unnecessary antibiotic administration may cause problems of antibiotic resistance; hence it's necessary to rely on early diagnostic markers such as blood counts, micro-ESR, CRP, Procalcitonin.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of C-reactive protein versus procalcitonin as an early marker of neonatal sepsis

Thayi¹,

Ramesh²

2016

Int J Contemp Pediatr

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Blood Culture Isolates in Neonatal Sepsis and their Sensitivity in Anand District of India

Abstract: Gram negative organisms were most common cause of neonatal sepsis and were resistant to first line antibiotics. Blood culture positive newborns had poor outcome than culture negative newborns.

Cited by 19 publications

References 22 publications

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Prevalence and Antibiotic Resistance of Neonatal Sepsis Pathogens in Neyshabour, Iran

Bacteriological profile and antimicrobial sensitivity pattern in neonatal sepsis: a study from North India

Comparative study of C-reactive protein versus procalcitonin as an early marker of neonatal sepsis

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